Alignment tool facilitates pin placement on irregular horizontal surfaces

Alignment tool facilitates spotting and cementing plastic pins on the true vertical to irregular concave and convex surfaces. The tool consists of a wood tripod with individually adjustable legs, a wood block with a hole for placing the pins and two spirit levels at a 90 degree angle for easy alignment

Adjustable attitude guide device Patent

Development of adjustable attitude guide block for setting pins perpendicular to irregular convex work surfac

Hydrolysed formula and risk of allergic or autoimmune disease: a systematic review and meta-analysis

Objective To determine whether feeding infants with hydrolysed formula reduces their risk of allergic or autoimmune disease. Design Systematic review and meta-analysis, as part of a series of systematic reviews commissioned by the UK Food Standards Agency to inform guidelines on infant feeding. Two authors selected studies by consensus, independently extracted data, and assessed the quality of included studies using the Cochrane risk of bias tool. Data sources Medline, Embase, Web of Science, CENTRAL, and LILACS searched between January 1946 and April 2015. Eligibility criteria for selecting studies Prospective intervention trials of hydrolysed cows’ milk formula compared with another hydrolysed formula, human breast milk, or a standard cows’ milk formula, which reported on allergic or autoimmune disease or allergic sensitisation. Results 37 eligible intervention trials of hydrolysed formula were identified, including over 19 000 participants. There was evidence of conflict of interest and high or unclear risk of bias in most studies of allergic outcomes and evidence of publication bias for studies of eczema and wheeze. Overall there was no consistent evidence that partially or extensively hydrolysed formulas reduce risk of allergic or autoimmune outcomes in infants at high pre-existing risk of these outcomes. Odds ratios for eczema at age 0-4, compared with standard cows’ milk formula, were 0.84 (95% confidence interval 0.67 to 1.07; I2=30%) for partially hydrolysed formula; 0.55 (0.28 to 1.09; I2=74%) for extensively hydrolysed casein based formula; and 1.12 (0.88 to 1.42; I2=0%) for extensively hydrolysed whey based formula. There was no evidence to support the health claim approved by the US Food and Drug Administration that a partially hydrolysed formula could reduce the risk of eczema nor the conclusion of the Cochrane review that hydrolysed formula could allergy to cows’ milk. Conclusion These findings do not support current guidelines that recommend the use of hydrolysed formula to prevent allergic disease in high risk infants

Canister closing device Patent

Design and characteristics of device for closing canisters under high vacuum condition

PET/PDT theranostics: Synthesis and biological evaluation of a peptide-targeted gallium porphyrin

The development of novel theranostic agents is an important step in the pathway towards personalised medicine, with the combination of diagnostic and therapeutic modalities into a single treatment agent naturally lending itself to the optimisation and personalisation of treatment. In pursuit of the goal of a molecular theranostic suitable for use as a PET radiotracer and a photosensitiser for PDT, a novel radiolabelled peptide–porphyrin conjugate targeting the α6β1-integrin has been developed. 69/71Ga and 68Ga labelling of an azide-functionalised porphyrin has been carried out in excellent yields, with subsequent bioconjugation to an alkyne-functionalised peptide demonstrated. α6β1-integrin expression of two cell lines has been evaluated by flow cytometry, and therapeutic potential of the conjugate demonstrated. Evaluation of the phototoxicity of the porphyrin–peptide theranostic conjugate in comparison to an untargeted control porphyrin in vitro, demonstrated significantly enhanced activity for a cell line with higher α6β1-integrin expression when compared with a cell line exhibiting lower α6β1-integrin expression

Do Quasars Lens Quasars?

If the unexpectedly high frequency of quasar pairs with very different component redshifts is due to the lensing of a population of background quasars by the foreground quasar, typical lens masses must be \sim10^{12}M_{\sun} and the sum of all such quasar lenses would have to contain $\sim0.005$ times the closure density of the Universe. It then seems plausible that a very high fraction of all \sim10^{12} M_{\sun} gravitational lenses with redshifts $z\sim1$ contain quasars. Here I propose that these systems have evolved to form the present population of massive galaxies with M$_{\rm B}\leq-22$ and M >5\times10^{11} M_{\sun}.Comment: 6 pages, aas style, ams symbols, ApJL (accepted

Quantum Spin Hall Effect and Enhanced Magnetic Response by Spin-Orbit Coupling

We show that the spin Hall conductivity in insulators is related with a magnetic susceptibility representing the strength of the spin-orbit coupling. We use this relationship as a guiding principle to search real materials showing quantum spin Hall effect. As a result, we theoretically predict that bismuth will show the quantum spin Hall effect, both by calculating the helical edge states, and by showing the non-triviality of the Z_2 topological number, and propose possible experiments.Comment: 5 pages, 2 figures, accepted for publication in Phys. Rev. Let

An algebraic turbulence model for three-dimensional viscous flows

An algebraic turbulence model is proposed for use with three-dimensional Navier-Stokes analyses. It incorporates features of both the Baldwin-Lomax and Cebeci-Smith models. The Baldwin-Lomax model uses the maximum of a function f(y) to determine length and velocity scales. An analysis of the Baldwin-Lomax model shows that f(y) can have a spurious maximum close to the wall, causing numerical problems and non-physical results. The proposed model uses integral relations to determine delta(*) u(sub e) and delta used in the Cebeci-Smith mode. It eliminates a constant in the Baldwin-Lomax model and determines the two remaining constants by comparison to the Cebeci-Smith formulation. Pressure gradient effects, a new wake model, and the implementation of these features in a three-dimensional Navier-Stokes code are also described. Results are shown for a flat plate boundary layer, an annular turbine cascade, and endwall heat transfer in a linear turbine cascade. The heat transfer results agree well with experimental data which shows large variations in endwall Stanton number contours with Reynolds number

Toward improved streamflow forecasts: Value of semidistributed modeling

The focus of this study is to assess the performance improvements of semidistributed applications of the U.S. National Weather Service Sacramento Soil Moisture Accounting model on a watershed using radar-based remotely sensed precipitation data. Specifically, performance comparisons are made within an automated multicriteria calibration framework to evaluate the benefit of "spatial distribution" of the model input (precipitation), structural components (soil moisture and streamflow routing computations), and surface characteristics (parameters). A comparison of these results is made with those obtained through manual calibration. Results indicate that for the study watershed, there are performance improvements associated with semidistributed model applications when the watershed is partitioned into three subwatersheds; however, no additional benefit is gained from increasing the number of subwatersheds from three to eight. Improvements in model performance are demonstrably related to the spatial distribution of the model input and streamflow routing. Surprisingly, there is no improvement associated with the distribution of the surface characteristics (model parameters)