10,722 research outputs found
Observations of QSO J2233-606 in the Southern Hubble Deep Field
The Hubble Deep Field South (HDF-S) HST observations are expected to begin in
October 1998. We present a composite spectrum of the QSO in the HDF-S field
covering UV/optical/near IR wavelengths, obtained by combining data from the
ANU 2.3m Telescope with STIS on the HST. This intermediate resolution spectrum
covers the range 1600-10000A and allows us to derive some basic information on
the intervening absorption systems which will be important in planning future
higher resolution studies of this QSO.Comment: 9 pages and 2 figures, submitted to ApJ
High-resolution mapping of cancer cell networks using co-functional interactions.
Powerful new technologies for perturbing genetic elements have recently expanded the study of genetic interactions in model systems ranging from yeast to human cell lines. However, technical artifacts can confound signal across genetic screens and limit the immense potential of parallel screening approaches. To address this problem, we devised a novel PCA-based method for correcting genome-wide screening data, bolstering the sensitivity and specificity of detection for genetic interactions. Applying this strategy to a set of 436 whole genome CRISPR screens, we report more than 1.5 million pairs of correlated "co-functional" genes that provide finer-scale information about cell compartments, biological pathways, and protein complexes than traditional gene sets. Lastly, we employed a gene community detection approach to implicate core genes for cancer growth and compress signal from functionally related genes in the same community into a single score. This work establishes new algorithms for probing cancer cell networks and motivates the acquisition of further CRISPR screen data across diverse genotypes and cell types to further resolve complex cellular processes
The Major Sources of the Cosmic Reionizing Background at z ~ 6
In this paper, we address which sources contributed most of the reionizing
photons. Our argument assumes that the reionization ended around z ~ 6 and that
it was a relatively quick process, i.e., that there was a non-negligible
fraction of neutral hydrogen in the Universe at somewhat earlier epochs.
Starting from our earlier estimate of the luminosity function (LF) of galaxies
at z ~ 6, we quantitatively show that the major sources of reionization are
most likely galaxies with L < L*. Our approach allows us to put stronger
constraints to the LF of galaxies at z ~ 6. To have the Universe completely
ionized at this redshift, the faint-end slope of the LF should be steeper than
, which is the value measured at lower redshifts (z ~ 3), unless
either the normalization (Phi*) of the LF or the clumping factor of the ionized
hydrogen has been significantly underestimated. If Phi* is actually lower than
what we assumed by a factor of two, a steep slope close to is
required. Our LF predicts a total of 50 -- 80 z ~ 6 galaxies in the HST Ultra
Deep Field (UDF) to a depth of AB=28.4 mag, which can be used to constraint
both Phi* and . We conclude that the least luminous galaxies existing
at this redshift should reach as low as some critical luminosity in order to
accumulate the entire reionizing photon budget. On the other hand, the
existence of significant amounts of neutral hydrogen at slightly earlier
epochs, e.g. z ~ 7, requires that the least luminous galaxies should not be
fainter than another critical value (i.e., the LF should cut-off at this
point).Comment: ApJL in press (Jan 1, 2004 issue
Impact of ETO propellants on the aerothermodynamic analyses of propulsion components
The operating conditions and the propellant transport properties used in Earth-to-Orbit (ETO) applications affect the aerothermodynamic design of ETO turbomachinery in a number of ways. Some aerodynamic and heat transfer implications of the low molecular weight fluids and high Reynolds number operating conditions on future ETO turbomachinery are discussed. Using the current SSME high pressure fuel turbine as a baseline, the aerothermodynamic comparisons are made for two alternate fuel turbine geometries. The first is a revised first stage rotor blade designed to reduce peak heat transfer. This alternate design resulted in a 23 percent reduction in peak heat transfer. The second design concept was a single stage rotor to yield the same power output as the baseline two stage rotor. Since the rotor tip speed was held constant, the turbine work factor doubled. In this alternate design, the peak heat transfer remained the same as the baseline. While the efficiency of the single stage design was 3.1 points less than the baseline two stage turbine, the design was aerothermodynamically feasible, and may be structurally desirable
Hadronic contribution to the muon g-2: a theoretical determination
The leading order hadronic contribution to the muon g-2, , is
determined entirely from theory using an approach based on Cauchy's theorem in
the complex squared energy s-plane. This is possible after fitting the
integration kernel in with a simpler function of . The
integral determining in the light-quark region is then split
into a low energy and a high energy part, the latter given by perturbative QCD
(PQCD). The low energy integral involving the fit function to the integration
kernel is determined by derivatives of the vector correlator at the origin,
plus a contour integral around a circle calculable in PQCD. These derivatives
are calculated using hadronic models in the light-quark sector. A similar
procedure is used in the heavy-quark sector, except that now everything is
calculable in PQCD, thus becoming the first entirely theoretical calculation of
this contribution. Using the dual resonance model realization of Large
QCD to compute the derivatives of the correlator leads to agreement with the
experimental value of . Accuracy, though, is currently limited by the
model dependent calculation of derivatives of the vector correlator at the
origin. Future improvements should come from more accurate chiral perturbation
theory and/or lattice QCD information on these derivatives, allowing for this
method to be used to determine accurately entirely from theory,
independently of any hadronic model.Comment: Several additional clarifying paragraphs have been added. 1/N_c
corrections have been estimated. No change in result
Limb radiance inversion radiometer
Engineering and scientific objectives of the LRIR experiment are described along with system requirements, subassemblies, and experiment operation. The mechanical, electrical, and thermal interfaces between the LRIR experiment and the Nimbus F spacecraft are defined. The protoflight model qualification and acceptance test program is summarized. Test data is presented in tables to give an overall view of each test parameter and possible trends of the performance of the LRIR experiment. Conclusions and recommendations are included
Gravitational Lens Statistics and The Density Profile of Dark Halos
We investigate the influence of the inner profile of lens objects on
gravitational lens statistics taking into account of the effect of
magnification bias and both the evolution and the scatter of halo profiles. We
take the dark halos as the lens objects and consider the following three models
for the density profile of dark halos; SIS (singular isothermal sphere), the
NFW (Navarro Frenk White) profile, and the generalized NFW profile which has a
different slope at smaller radii. The mass function of dark halos is assumed to
be given by the Press-Schechter function. We find that magnification bias for
the NFW profile is order of magnitude larger than that for SIS. We estimate the
sensitivity of the lensing probability of distant sources to the inner profile
of lenses and to the cosmological parameters. It turns out that the lensing
probability is strongly dependent on the inner density profile as well as on
the cosmological constant. We compare the predictions with the largest
observational sample, the Cosmic Lens All-Sky Survey. The absence or presence
of large splitting events in larger surveys currently underway such as the 2dF
and SDSS could set constraints on the inner density profile of dark halos.Comment: 22 pages, minor changes and references added, accepted for
publication in Ap
Some continuum physics results from the lattice V-A correlator
We present preliminary results on extractions of the chiral LECs L_10 and
C_87 and constraints on the excited pseudoscalar state pi(1300) and pi(1800)
decay constants obtained from an analysis of lattice data for the flavor ud
light quark V-A correlator. A comparison of the results for the correlator to
the corresponding mildly-model-dependent continuum results (based primarily on
experimental hadronic tau decay data) is also givenComment: 7 pages, 3 figures. Prepared for the Proceedings of the 30th
International Symposium on Lattice Field Theory, Cairns, Australia, June
24-29, 2012; expanded version of Reference 1
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