Reporting Science and Conflicts of Interest in the Lay Press

BACKGROUND: Forthright reporting of financial ties and conflicts of interest of researchers is associated with public trust in and esteem for the scientific enterprise. METHODS/PRINCIPAL FINDINGS: We searched Lexis/Nexis Academic News for the top news stories in science published in 2004 and 2005. We conducted a content analysis of 1152 newspaper stories. Funders of the research were identified in 38% of stories, financial ties of the researchers were reported in 11% of stories, and 5% reported financial ties of sources quoted. Of 73 stories not reporting on financial ties, 27% had financial ties publicly disclosed in scholarly journals. CONCLUSIONS/SIGNIFICANCE: Because science journalists often did not report conflict of interest information, adherence to gold-standard recommendations for science journalism was low. Journalists work under many different constraints, but nonetheless news reports of scientific research were incomplete, potentially eroding public trust in science

Clinical Impact of a Novel Interprofessional Dental and Pharmacy Student Tobacco Cessation Education Program on Dental Patients

Objectives: • To compare the difference between IPE care and standard care (SC) groups regarding dental patients\u27 perceptions of knowledge gained about tobacco cessation, intentions to quit tobacco use, and quit attempts at follow-up. • To evaluate perceptions of IPE care. Background: Based on the link between tobacco use and oral health and the frequent contact between dental providers and patients, the dental clinic is an ideal setting to address tobacco use.1 • Many dentists feel unprepared providing tobacco cessation education, particularly pharmacologic treatment options.1-3 • Pharmacists promote safe and effective pharmacologic treatment options for tobacco dependence and patients’ perceptions toward pharmacist-provided tobacco cessation education have been positive.4-6 • A novel interprofessional education (IPE) program involving dental and pharmacy students may address the need for tobacco cessation education in the dental clinic setting

Life Stories Between the Former Soviet Union and the United States

This paper examines the change from the Soviet Period to Transition Period, as reported through the experiences of those who grew up there, as well as from American tourists who have traveled there. Five semi-structured interviews were been conducted. They were transcribed and analyzed inductively to understand (a) differences in life experiences across cultures, (b) how change in government effects a person\u27s life story and (c) the importance of social traditions. Findings focus on the transformation of economic conditions from the point before the transition to independent republics after the transition. Findings focus on technological expansion and traditions and customs surrounding alcohol consumption

Pregnant Questions: The Importance of Pragmatic Awareness in Maternal Health Question Answering

Questions posed by information-seeking users often contain implicit false or potentially harmful assumptions. In a high-risk domain such as maternal and infant health, a question-answering system must recognize these pragmatic constraints and go beyond simply answering user questions, examining them in context to respond helpfully. To achieve this, we study assumptions and implications, or pragmatic inferences, made when mothers ask questions about pregnancy and infant care by collecting a dataset of 2,727 inferences from 500 questions across three diverse sources. We study how health experts naturally address these inferences when writing answers, and illustrate that informing existing QA pipelines with pragmatic inferences produces responses that are more complete, mitigating the propagation of harmful beliefs.Comment: Accepted to NAACL 202

Frequency tunable near-infrared metamaterials based on VO_2 phase transition

Engineering metamaterials with tunable resonances from mid-infrared to near-infrared wavelengths could have far-reaching consequences for chip based optical devices, active filters, modulators, and sensors. Utilizing the metal-insulator phase transition in vanadium oxide (VO_2), we demonstrate frequency-tunable metamaterials in the near-IR range, from 1.5 - 5 microns. Arrays of Ag split ring resonators (SRRs) are patterned with e-beam lithography onto planar VO_2 and etched via reactive ion etching to yield Ag/VO_2 hybrid SRRs. FTIR reflection data and FDTD simulation results show the resonant peak position red shifts upon heating above the phase transition temperature. We also show that, by including coupling elements in the design of these hybrid Ag/VO_2 bi-layer structures, we can achieve resonant peak position tuning of up to 110 nm

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

AbstractT cell responsiveness to an epitope is affected both by its affinity for the presenting MHC molecule and the affinity of the MHC-peptide complex for TCR. One limitation of cancer immunotherapy is that natural tumor antigens elicit relatively weak T cell responses, in part because high-affinity T cells are rendered tolerant to these antigens. We report here that amino acid substitutions in a natural MHC class I–restricted tumor antigen that increase the stability of the MHC-peptide-TCR complex are significantly more potent as tumor vaccines. The improved immunity results from enhanced in vivo expansion of T cells specific for the natural tumor epitope. These results indicate peptides that stabilize the MHC-peptide-TCR complex may provide superior antitumor immunity through enhanced stimulation of specific T cells

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS). Using a panel of contiguous cDNAs that span the entire genome, we have assembled a full-length cDNA of the SARS-CoV Urbani strain, and have rescued molecularly cloned SARS viruses (infectious clone SARS-CoV) that contained the expected marker mutations inserted into the component clones. Recombinant viruses replicated as efficiently as WT virus and both were inhibited by treatment with the cysteine proteinase inhibitor (2S,3S)-transepoxysuccinyl-l-leucylamido-3-methylbutane ethyl ester. In addition, subgenomic transcripts were initiated from the consensus sequence ACGAAC in both the WT and infectious clone SARS-CoV. Availability of a SARS-CoV full-length cDNA provides a template for manipulation of the viral genome, allowing for the rapid and rational development and testing of candidate vaccines and therapeutics against this important human pathogen