Prospects of supervising service development as the tool of input quality control

Supervising provides a foothold in the Russian Federation domestic market of oilfield services. Despite the rapid growth of supervising services market, there is still a definite demand in developing this domain. The authors consider the implementation of supervising in Russian oil and gas industry sector, as well as the possible execution paths of its improvement and development

Development of engineering solutions for air drilling at Dulisminsk oilfield, Irkutsk oblast

The article presents the analysis of disastrous mud loss achieved during casing at Dulisminsk oil and gas condensate field (DOGCF) and comparative evaluation of geological structure of DOGCF and Naryksko-Ostashkinsk area of Kemerovo oblast, where the same problem was solved successfully. On the basis of the analysis, an engineering solution is proposed to prevent mud loss in the conditions of DOGCF

Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia

Background: Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with antipsychotic drugs. It has been suggested to be related to a malfunctioning of the indirect pathway of the motor part of the cortical-striatal-thalamic-cortical circuit, which may be caused by oxidative stress-induced neurotoxicity. Methods: The purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia. The Abnormal Involuntary Movement Scale was used to assess tardive dyskinesia. Individuals were genotyped for 3 single nucleotide polymorphisms in PIP5K2A gene: rs10828317, rs746203, and rs8341. Results: A significant association was established between the functional mutation N251S-polymorphism of the PIP5K2A gene (rs10828317) and tardive dyskinesia, while the other 2 examined nonfunctional single nucleotide polymorphisms were not related. Conclusions: We conclude from this association that PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. This corresponds to our hypothesis that tardive dyskinesia is related to neurotoxicity at striatal indirect pathway medium-sized spiny neurons

Diagnostics of acute kidney injury after surgery for invasive urinary bladder cancer

We have studied diagnostic techniques for renal dysfunction (glomerular filtration rate) and renal structure lesions (NGAL, p2-microglobulin in blood serum and urine) before and at different stages of radical surgery. Diagnostic criteria of acute kidney injury without changes in the concentration of functional markers have been identified. Evaluation of the predictability of the development of chronic kidney diseases in the remote postoperative period has been made.Изучены способы диагностики нарушения функции почек (скорость клубочковой фильтрации) и повреждения ренальных структур (NGAL, р2-микроглобулин в плазме крови и моче) до и на различных этапах радикального хирургического лечения. Выявлены диагностические критерии острого повреждения почек при отсутствии изменений концентрации функциональных маркеров. Проведена оценка возможности прогнозирования развития хронической болезни почек в отдаленном послеоперационном периоде

International economic relations and sustainable development

Монографія присвячена дослідженню теоретичних та практичних аспектів сталого розвитку на сучасному етапі міжнародних економічних відносин. Розглядаються інноваційні методичні підходи та економічні механізми забезпечення сталого розвитку на регіональному, національному та міжнародному рівнях. Наведено науково обгрунтовані рекомендації щодо досягнення економічних, соціальних та екологічних цілей сталого розвитку шляхом зміцнення інтеграційних процесів та міжнародного співробітництва між країнами світу.Монография посвящена исследованию теоретических и практических аспектов устойчивого развития на современном этапе международных экономических отношений. Рассмотрены инновационные методические подходы и экономические механизмы для обеспечения устойчивого развития на региональном, национальном и международном уровнях. Даны научно обоснованные рекомендации по достижению экономических, социальных и экологических целей устойчивого развития посредством укрепления интеграционных процессов и международного сотрудничества между странами мира.Monograph is devoted to the research of theoretical and practical aspects of the sustainable development at the present stage of international economic relations. Innovative methodic approaches and economic mechanisms to provide sustainable development at the regional, national and international levels are considered. Scientifically grounded recommendations to achieve economic, social and ecological aims of the sustainable development through the strengthening of integration processes and international cooperation between countries of the world are given

Клеточный состав индуцированной мокроты и оксид азота в конденсате выдыхаемого воздуха при бронхиальной астме

Induced sputum cytology, nitric oxide content in exhaled breath condensate and dynamics of these parameters against the background of glucocorticosteroid therapy were studied in patients with bronchial asthma exacerbation. Sixty four patients with different degree of bronchial asthma were included. The control group was represented by 20 healthy volunteers. It is shown, that monitoring of induced sputum and nitric oxide indices is informative to assess efficiency of anti-inflammatory therapy in bronchial asthma patients.Изучен клеточный состав индуцированной мокроты и содержание оксида азота в конденсате выдыхаемого воздуха у больных с обострением бронхиальной астмы и динамика этих показателей на фоне терапии глюкокортикостероидами. Обследовано 64 пациента с различной степенью тяжести бронхиальной астмы. Группу контроля составили 20 здоровых добровольцев. Показано, что мониторинг показателей индуцированной мокроты и содержания оксида азота является информативным в оценке эффективности противовоспалительной терапии бронхиальной астмы

Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility

Objectives. The aim of this study was to investigate a possible association between tardive dyskinesia (TD) and CYP1A2 (*1F, -163C>А, rs762551) polymorphism in Russian psychiatric inpatients. Methods. TD was assessed cross-sectionally using the Abnormal Involuntary Movement Scale (AIMS). Orofacial and limb-truncal dyskinesia were assessed with AIMS 1-4 and 5-7, respectively. Standard protocols were applied for genotyping. Analysis of covariance (ANCOVA) was used to compare the mean AIMS scores for each of the genotypic classes. Results. A total of 319 Caucasian patients from West Siberia with schizophrenia and 117 healthy volunteers were investigated. No significant differences between the patients and the controls in genotype frequencies were found. Analysis of covariance (ANCOVA) with age, sex, duration of disease, chlorpromazine equivalent (CPZEQ) incorporated as covariates showed that limb-truncal, but not orofacial TD, is associated with CYP1A2 (-163C>, rs762551) polymorphism (F = 3.27, P = 0.039). Patients with the C/C genotype had a higher mean AIMS 5-7 score than those with the A/C or the A/A genotype. Conclusions. Our results support the hypothesis that not only with clozapine, but also with other classical and atypical antipsychotics, smoking may decrease plasma levels; this is most extensively expressed in carriers of the CYP1A2*1F (-163C> A) polymorphism