Association of myasthenia gravis and Behçet's disease: A case report

Myasthenia gravis is a disease of neuromuscular junction due to auto-immune destruction of the acetylcholine receptors. Behçet's disease, on the other hand, is a multisystemic vascular-inflammatory disease. Both conditions are not common in the general population although their association has not been reported in the literature. We wanted to present our patient who developed clinical course of myasthenia gravis following discontinuation of medications due to complications of corticosteroid for Behçet's disease. It was observed that clinical findings of myasthenia gravis recovered following restarting steroid treatment and he did not experience attacks of both conditions. Although Myasthenia gravis and Behçet's disease are distinct entities clinically as well as in terms of pathogenesis, they share common physiopathological features and their treatment is based on their common features

Comparison of the Effects of Ketamine or Lidocaine on Fentanyl-Induced Cough in Patients Undergoing Surgery: A Prospective, Double-Blind, Randomized, Placebo-Controlled Study

BACKGROUND: Fentanyl-induced cough is common but has not been viewed as a serious anesthetic problem. However, the cough may be explosive at times, may require immediate intervention, and may be associated with undesirable increases in intracranial, intraocular, and intra-abdominal pressures. Prevention of fentanyl-induced cough in such situations is of paramount importance. Ketamine, at concentrations achieved with standard clinical doses, has a direct relaxant effect on airway smooth muscle

The effects of sevoflurane anesthesia in two different fresh gase flow on anesthesia cost, hepatic and renal functions İki farkli taze gaz akimi i̇çinde sevofluranin anestezi maliyeti, karaciǧer ve böbrek fonksiyonlarma etkisi

Aim: The aim of this study is to investigate the effects of 6 L min -1 and 3 L min-1 fresh gase flow during the sevoflurane anesthesia on the anesthesia cost, renal and hepatic functions. Materials and Methods: This study was performed on 90 patients, aged between 18-50 years, scheduled for elective surgery. Semi-closed respiration system was used for anesthesia. Patients were randomized into two groups. In both groups for first 5 minutes, anesthesia was maintained with % 1-2 sevoflurane in 6 L min -1 (2 L min-1 O2 + 4 L min-1 N 2O) of fresh gas flow and after then, anesthesia was maintained with % 1-2 sevoflurane concantration in 3 L min-1 of fresh gas flow (1 L min-1 O2 + 2 L min-1 N2O) in Group I ( n=45) and 6 L min-1 of fresh gas flow (2 L min-1 O 2 + 4 L min-1 N2O) in group II ( n=45). Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), end-tidal carbondioxide (ETCO2) and end-tidal sevoflurane (ETsevo) were recorded during the operation at 15 minute intervals. Arterial blood samples were taken for arterial blood gas analysis and venous blood samples were taken for blood urea nitrogen (BUN), creatinine, aspartate amino transferase (AST), alanine amino transferase (ALT), gama glutamyl transferase (GGT) and total bilirubine levels. Sevoflurane consumptions for all patients were recorded. Results: There were no statistical difference in HR, SAP, DAP, SpO2, EtCO2, Etsevo, SaO2, PaO2, PaCO2, pH and serum AST, ALT, GGT, total bilirubine, BUN and blood creatinine levels between the groups (p>0.05). Sevoflurane consumption was statisticaly higher in group II than in group I (p<0.05). Conclusion: By using semi-closed anesthesia system with decreased fresh gase flow from 6 L min-1 to 3 L min-1, sevoflurane consumption was 51 % decreased without any changes in hepatic and renal functions

The effects of flumazenile and naloxone on antinociception of dexmedetomidine Deksmedetomidin ile saǧlanan antinosisepsiyon üzerine flumazenil ve naloksonun etkisi

Purpose: The aim of this study was to search the effects of flumazenil and naloxane, which are frequently used in intensive care units for benzodiazepine and opioid antagonism, on dexmedetomidine's antinociceptive effect. Material and Methods: 50 Bulb-C albino mice, weight between 25-35 grams, were used in the study. Mice were randomized in to 5 groups (n=10). Serum physiologic, 200 μg/kg of dexmedetomidine, 1 mg/kg of yohimbine + 200 μg/kg of dexmedetomidine, 1 mg/kg of flumazenil + 200 μg/kg of dexmedetomidine or 2 mg/kg of naloxone + 200 μg/kg of dexmedetomidine were applied to each mouse in every group. Although no significant analgesic effect was observed in 20., 40., 60., and 80. minutes in control group and yohimbine + dexmedetomidine group, the analgesic effects of drugs; applied to other groups were observed. The accompanying application of dexmedetomidine and yohimbine abolished its analgesic effect of dexmedetomidine, however, there were no statistical difference when compared to groups which dexmedetomidine is applied with flumazenil and naloxone. Conclusion: We could not find any effect of flumazenil and naloxane on antinociceptive effect of dexmedetomidine

The effects of flumazenile and naloxone on antinociception of dexmedetomidine Deksmedetomidin ile saǧlanan antinosisepsiyon üzerine flumazenil ve naloksonun etkisi

Purpose: The aim of this study was to search the effects of flumazenil and naloxane, which are frequently used in intensive care units for benzodiazepine and opioid antagonism, on dexmedetomidine's antinociceptive effect. Material and Methods: 50 Bulb-C albino mice, weight between 25-35 grams, were used in the study. Mice were randomized in to 5 groups (n=10). Serum physiologic, 200 μg/kg of dexmedetomidine, 1 mg/kg of yohimbine + 200 μg/kg of dexmedetomidine, 1 mg/kg of flumazenil + 200 μg/kg of dexmedetomidine or 2 mg/kg of naloxone + 200 μg/kg of dexmedetomidine were applied to each mouse in every group. Although no significant analgesic effect was observed in 20., 40., 60., and 80. minutes in control group and yohimbine + dexmedetomidine group, the analgesic effects of drugs; applied to other groups were observed. The accompanying application of dexmedetomidine and yohimbine abolished its analgesic effect of dexmedetomidine, however, there were no statistical difference when compared to groups which dexmedetomidine is applied with flumazenil and naloxone. Conclusion: We could not find any effect of flumazenil and naloxane on antinociceptive effect of dexmedetomidine