In Situ Catchment Scale Sampling of Emerging Contaminants Using Diffusive Gradients in Thin Films (DGT) and Traditional Grab Sampling:A Case Study of the River Thames, UK

The in situ passive sampling technique, diffusive gradients in thin films (DGT), confronts many of the challenges associated with current sampling methods used for emerging contaminants (ECs) in aquatic systems. This study compared DGT and grab sampling for their suitability to screen and monitor ECs at the catchment scale in the River Thames system (U.K.) and explored their sources and environmental fate. The ubiquitous presence of endocrine disrupting chemicals, parabens, and their metabolites is of concern. This study is the first to report organophosphate esters (OPEs) in the study area. TEP (summer 13-160 and winter 18-46, ng/L) and TCPP (summer 242-4282 and winter 215-854, ng/L) were the main OPEs. For chemicals which were relatively stable in the rivers, DGT and grab sampling were in good agreement. For chemicals which showed high variation in water bodies, DGT provided a better integral of loadings and exposure than grab sampling. DGT was not as sensitive as grab sampling under the procedures employed here, but there are several options to improve it to give comparable/better performance. DGT samples require shorter preparation time for analysis in the laboratory than grab samples. Overall, DGT can be a powerful tool to characterize ECs throughout a large dynamic water system

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Non-timber values and the optimal forest rotation: An application to the southern forest of Tasmania

The present paper examines the optimal use of a site containing standing timber, taking account of both timber and non-timber values. Using a site in the southern forest of Tasmania for illustrative purposes, it calculates the relationships between age of stand, extent of timber and non-timber values and optimal cutting age. It finds that, for a stand with moderate potential environmental benefits, there is a period of its life during which it is optimal to log. This segment narrows, and eventually disappears, as potential environmental benefits increase

Disordered Eating Panel Discussion: Finding Help

“Disordered Eating Panel Discussion: Finding Help,” is the fourth of five in the, “Don’t Call Me Crazy: MU Mental Health Initiative,” panel discussion series, which was held on February 21, 2019. This initiative is comprised of three major components: “Resiliency through Education;” which includes: panel discussions with mental health professionals and a research guide, “Resiliency through Art;” an art exhibition that featured works form MU students, faculty and staff, and community members, and “Resiliency through Community;” an extensive collection of campus, local, state, and national mental health resources. Libraries hold a unique position as places to hold civil conversations on challenging subjects as well as purveyors of credible information in which to frame those conversations. The panel discussions provide opportunities for these conversations by bring experts together to answer questions and dispel misinformation. “Disordered Eating Panel Discussion: Finding Help,” discusses topics such as: anorexia, childhood obesity, peer support, mental and behavioral comorbidity, barriers to treatment, early intervention, bariatric surgery, mental health acceptance, family education, West Virginia resources, emotional and trauma eating, causes of disordered eating, body dysmorphia, suicide, disordered eating in children. Panelists include: Dr. Kelli Williams, Dr. Candace Layne, Dr. James Bailes, Dr. Kristina Bryant-Melvin, Brittany Chapman, Alicia Lewis Kiss and Tiffany Bowes. Moderator: Sabrina Thomas