242 research outputs found

    Constraining churning and blurring in the Milky Way using large spectroscopic surveys -- an exploratory study

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    We have investigated the possibilities to quantify how much stars move in the Milky Way stellar disk due to diffuse processes (i.e. so called blurring) and due to influences from spiral arms and the bar (i.e. so called churning). To this end we assume that it is possible to infer the formation radius of a star if we know their elemental abundances and age as well as the metallicity profile of the interstellar medium at the time of the formation of the star. Using this information, coupled with orbital information derived from Gaia DR2 data and radial velocities from large spectroscopic surveys, we show that it is possible to isolate stellar samples such that we can start to quantify how important the role of churning is. We use data from APOGEE DR14, parallaxes from Gaia and stellar ages based on C and N elemental abundances in the stars. In our sample, we find that about half of the stars have experienced some sort of radial migration (based solely on their orbital properties), 10 % have likely have suffered only from churning, whilst a modest 5-7 % of stars have never experienced either churning or blurring making them ideal tracers of the original properties of the cool stellar disk. Our investigation shows that it is possible to put up a framework where we can begin to quantify churning and blurring an important. Important aspects for future work would include to investigate how selection effects should be accounted for.Comment: Paper submitted to MNRAS. Comments are welcom

    High-throughput discovery of rare human nucleotide polymorphisms by Ecotilling

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    Human individuals differ from one another at only ∼0.1% of nucleotide positions, but these single nucleotide differences account for most heritable phenotypic variation. Large-scale efforts to discover and genotype human variation have been limited to common polymorphisms. However, these efforts overlook rare nucleotide changes that may contribute to phenotypic diversity and genetic disorders, including cancer. Thus, there is an increasing need for high-throughput methods to robustly detect rare nucleotide differences. Toward this end, we have adapted the mismatch discovery method known as Ecotilling for the discovery of human single nucleotide polymorphisms. To increase throughput and reduce costs, we developed a universal primer strategy and implemented algorithms for automated band detection. Ecotilling was validated by screening 90 human DNA samples for nucleotide changes in 5 gene targets and by comparing results to public resequencing data. To increase throughput for discovery of rare alleles, we pooled samples 8-fold and found Ecotilling to be efficient relative to resequencing, with a false negative rate of 5% and a false discovery rate of 4%. We identified 28 new rare alleles, including some that are predicted to damage protein function. The detection of rare damaging mutations has implications for models of human disease

    A rotating three component perfect fluid source and its junction with empty space-time

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    The Kerr solution for empty space-time is presented in an ellipsoidally symmetric coordinate system and it is used to produce generalised ellipsoidal metrics appropriate for the generation of rotating interior solutions of Einstein's equations. It is shown that these solutions are the familiar static perfect fluid cases commonly derived in curvature coordinates but now endowed with rotation. The resulting solutions are also discussed in the context of T-solutions of Einstein's equations and the vacuum T-solution outside a rotating source is presented. The interior source for these solutions is shown not to be a perfect fluid but rather an anisotropic three component perfect fluid for which the energy momentum tensor is derived. The Schwarzschild interior solution is given as an example of the approach.Comment: 14 page

    Cluster Cepheids with High Precision Gaia Parallaxes, Low Zeropoint Uncertainties, and Hubble Space Telescope Photometry

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    We present HST photometry of 17 Cepheids in open clusters and their mean parallaxes from Gaia EDR3. These parallaxes are more precise than those from individual Cepheids (G<8 mag) previously used to measure the Hubble constant because they are derived from an average of >300 stars per cluster. Cluster parallaxes also have smaller systematic uncertainty because their stars lie in the range (G>13 mag) where the Gaia parallax calibration is most comprehensive. Cepheid photometry employed in the period--luminosity relation was measured using the same instrument(WFC3) and filters(F555W,F814W,F160W) as extragalactic Cepheids in SNIa hosts. We find no evidence of residual parallax offset in this magnitude range, zp=-3+/-4 muas, consistent with Lindegren:2021b and most studies. The Cepheid luminosity (P=10d, solar-metallicity) in the HST near-infrared, Wesenheit system derived from the cluster sample is M_{H,1}^W=-5.902+/-0.025 and -5.890+/-0.018 mag with or without simultaneous determination of a parallax offset, respectively. These results are similar to measurements from field Cepheids, confirming the accuracy of the Gaia parallaxes over a broad range of magnitudes. The SH0ES distance ladder calibrated solely from this sample gives H_0=72.8+/-1.3 and H_0=73.2+/-1.1 km/s/Mpc with or without offset marginalization; combined with all anchors we find H_0=73.01+/-0.99 and 73.15+/-0.97, respectively, a 5% or 7% reduction in the uncertainty and a 5.3 sigma Hubble Tension relative to Planck+LambdaCDM. It appears increasingly difficult to reconcile two of the best measured cosmic scales, parallaxes from Gaia and the angular size of the acoustic scale of the CMB, using the simplest form of LambdaCDM to join the two.Comment: 12 pages, submitted to ApJ, comments welcom
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