Negotiated Religious Meaning: Qing and Nationalist Approaches to Religious Superscription

This paper largely serves as a case study comparing the wildly divergent attempts, both in terms of execution and success, of the Qing dynasty and Nationalist regime in using religious symbols to appeal to the Chinese populace. While both attempted to win national support and popularity, religious superscription also reflected attempts to verify the legitimacy of the current government. Differences in the execution of religious superscription reflect the two varying approaches of the Qing and the Nationalists: an emphasis on utilizing tradition to promote imperial authority versus a total disregard of tradition in hopes of rapid change at a national level

EXT1 (exostoses (multiple) 1)

Review on EXT1 (exostoses (multiple) 1), with data on DNA, on the protein encoded, and where the gene is implicated

Moleculen, mechanismen, maatwerk

Oratie uitgesproken door Prof.dr. J.V.M.G. Bovée bij de aanvaarding van het ambt van hoogleraar Pathologie, in het bijzonder de Pathologie van Bot- en Wekedelentumoren aan de Universiteit Leiden op vrijdag 7 maart 2014LUMC / Geneeskund

Hereditary multiple exostoses (HME)

Review on Hereditary multiple exostoses (HME), with data on clinics, and the genes involved

Molecular pathology of sarcomas: concepts and clinical implications

The molecular genetic changes that have been described in sarcomas over the past era have aided our understanding of their pathogenesis. The majority of sarcomas carry nonspecific genetic changes within a background of a complex karyotype. These constitute the challenges in sarcoma research for unraveling a putative multistep genetic model, such as for chondrosarcoma, and finding targets for therapeutic strategies. Approximately 15–20% of mesenchymal tumors carry a specific translocation within a relatively simple karyotype. The resulting fusion products act either as transcription factors upregulating genes responsible for tumor growth, as for instance in Ewing sarcoma, or translocate a highly active promoter in front of an oncogene driving tumor formation, as for instance in aneurysmal bone cyst. In addition, a small subset of mesenchymal tumors have specific somatic mutations driving oncogenesis. The specific genetic changes unraveled so far had great impact on the classification of bone and soft tissue tumors. In addition, these changes can assist the pathologist in the differential diagnosis of some of these entities, especially within the groups of small blue round cell tumors and spindle cell tumors, if performed in specialized centers. While a putative association between certain fusion products and outcome is still under debate, the role of predicting response of targeted therapy has been well established for KIT and PDGFRA mutations in gastrointestinal stromal tumors

Bone: Vascular Tumours

Review on Bone: Vascular Tumours, with data on clinics, and the genes involved

Enchondromatosis

Review on Enchondromatosis, with data on clinics, and the genes involved