5,8-Dimeth­oxy-2-phenyl-1,4-dihydro­quinoline-3-carbonitrile

The crystal structure of the title mol­ecule, C18H16N2O2, can be described as two types of crossed layers parallel to the (110) and (10) planes. An intra­molecular N—H⋯O hydrogen bond occurs

2-Chloro-3-[(E)-(hydrazin-1-yl­idene)meth­yl]-6-meth­oxy­quinoline

In the title compound, C11H10ClN3O, the quinoline ring system is essentially planar, the r.m.s. deviation for the non-H atoms being 0.014 (2) Å with a maximum deviation from the mean plane of 0.0206 (14) Å for the C atom bonded to the –CH—N=NH2 group. In the crystal, molecules are linked via N—H⋯O and N—H⋯N hydrogen bonds, forming zigzag layers parallel to (010)

(3RS,4SR)-Methyl 4-(2-chloro-5,8-di­methoxy­quinolin-3-yl)-1-phenyl­pyrrolidine-3-carboxyl­ate

The mol­ecule of the title compound, C23H23ClN2O4, contains a quinolyl unit linked to a functionalized pyrrolidine system with a 3,4-trans arrangement of the substituents. The unit cell contains two stereoisomers that have the absolute stereochemistry 3S,4R and 3R,4S. The pyrrolidine ring adopts a twist conformation with pseudo-rotation parameters P = 258.2 (3)° and τ(M) = 35.3 (1)°. The packing is stabilized by C—H⋯π inter­actions and offset π–π stacking (centroid-to-centroid distance = 3.849 Å, inter­planar distance = 3.293 Å and slippage = 1.994 Å) between phenyl rings, leading to a two-dimensional network

2-Chloro­quinoline-3-carboxylic acid

The crystal structure of the title compound, C10H6ClNO2, can be described by two types of crossed layers which are parallel to (110) and (10). The crystal packing is stabilized by inter­molecular C—H⋯O and O—H⋯N hydrogen bonds, resulting in the formation of a two-dimensional network and reinforcing the cohesion of the structure

rac-2-(2-Chloro-6-methyl­quinolin-3-yl)-2,3-dihydro­quinolin-4(1H)-one

In the title compound, C19H15ClN2O, the quinoline ring forms a dihedral angle of 43.24 (1)° with the benzene ring of the dihydroquinolinyl system. In the crystal, mol­ecules are linked through a single weak C—H⋯O hydrogen bond, forming ribbons which extend along (100), giving alternating zigzag mol­ecular layers which stack down the b-axis direction

2-(2-Chloro-6,7-dimethyl­quinolin-3-yl)-2,3-dihydro­quinolin-4(1H)-one

In the title mol­ecule, C20H17ClN2O, the dihedral angle between the mean plane of the quinoline ring system and the benzene ring of the dihydro­quinolinone moiety is 57.84 (8)°. In the crystal, mol­ecules are linked into centrosymmetric dimers via pairs of inter­molecular N—H⋯N hydrogen bonds. These dimers are further stabilized by weak π–π stacking inter­actions between pyridine rings with a centroid–centroid distance of 3.9414 (12) Å

Synthesis of Some New 3-Pyrrolidinylquinoline Derivatives via 1,3-Dipolar Cycloaddition of Stabilized Azomethine Ylides to Quinolinyl α,β- Unsaturated Ketones

International audienceN-Metallated azomethine ylide generated from methyl (E)-N-benzylideneglycinate, LiBr and triethylamine underwent cycloaddition to quinolyl α,β- unsaturated ketones with excellent diastereoselectivity to afford new functionalised 3-pyrrolidinylquinoline derivatives

4,5-Dibromo-1,2-dimethyl-1H-imidazol-3-ium bromide

In the title salt, C5H7Br2N2 +·Br−, the cation and anion are connected by an N—H⋯Br hydrogen bond. In the crystal, there are inter­calated layers parallel to (10-2) in which bromide ions are located between the cations. Weak inter­molecular C—H⋯Br hydrogen bonds are also observed

Ethyl 4-(2-chloro­quinolin-3-yl)-1-phenyl-1H-pyrrole-3-carboxyl­ate

In the mol­ecule of the title compound, C22H17ClN2O2, the dihedral angles formed by the pyrrole ring with the quinoline and phenyl rings are 67.93 (8) and 28.40 (11)°, respectively. In the crystal structure, mol­ecules are linked into dimers by inter­molecular C—H⋯O hydrogen bonds

2-Bromo­ethyl 2-chloro-6-methyl­quinoline-3-carboxyl­ate

In the title compound, C13H11BrClNO2, the two rings of the quinoline group are fused in an axial fashion at a dihedral angle of 1.28 (9)°. In the crystal, molecules are arranged in zigzag layers along the c axis. The crystal packing is stabilized by weak C—H⋯O hydrogen bonds and inter­molecular inter­actions between Br and O atoms [Br⋯O= 3.076 (2) Å], resulting in the formation of a three-dimensional network