Modelling process knowledge in architectural design: A case-based approach

The paper presents on-going research aimed at the understanding and support of process knowledge in architectural design, from early and not sufficiently defined, to satisfactorily-defined phases. Today, technical, planning, management and environmental issues have created a scenario of such complexity that traditionally efficient control tools (e.g. technical manuals) are inadequate and there is a demand for new, integrated instruments to handle the decision process underlying architectural design. We assume design as a recursive and incrementally specified intentional planning activity, involving goals, constraints and their relationships. The essence of architectural design is thus encapsulated in the continual recursive transformation of the initial model, in order to map the desired state onto the enacted one. On the basis of this concept of design we describe the model of an environment aimed at progressively representing the enlarging space of acquired knowledge, and at supporting the designer's central role in the management of complexity

Autoregressive Point-Processes as Latent State-Space Models: a Moment-Closure Approach to Fluctuations and Autocorrelations

Modeling and interpreting spike train data is a task of central importance in computational neuroscience, with significant translational implications. Two popular classes of data-driven models for this task are autoregressive Point Process Generalized Linear models (PPGLM) and latent State-Space models (SSM) with point-process observations. In this letter, we derive a mathematical connection between these two classes of models. By introducing an auxiliary history process, we represent exactly a PPGLM in terms of a latent, infinite dimensional dynamical system, which can then be mapped onto an SSM by basis function projections and moment closure. This representation provides a new perspective on widely used methods for modeling spike data, and also suggests novel algorithmic approaches to fitting such models. We illustrate our results on a phasic bursting neuron model, showing that our proposed approach provides an accurate and efficient way to capture neural dynamics

Informazione esperienza memoria: verso una modellizzazione della conoscenza del processo progettuale con Galathea

Dottorato di ricerca in innovazione tecnica e progetto nell'architettura. 7. ciclo. A.a. 1992-95. Tutori E. Arlati e A. ScoccimarroConsiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7, Rome; Biblioteca Nazionale Centrale - P.za Cavalleggeri, 1, Florence / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

Contingency table comparing rate of MCI diagnosis assessed by ENB-2 (gold standard) vs. MoCA.

<p>Contingency table comparing rate of MCI diagnosis assessed by ENB-2 (gold standard) vs. MoCA.</p

Scores on ENB-2 neuropsychological tests: comparison with normative data, and number (% frequency) of impaired scores.

<p>Scores on ENB-2 neuropsychological tests: comparison with normative data, and number (% frequency) of impaired scores.</p

Psychological and neuropsychological data of patients (n = 65) from the different screening tests.

<p>Psychological and neuropsychological data of patients (n = 65) from the different screening tests.</p

Autologous stem cell transplantation with in vivo purged progenitor cells shows long-term efficacy in relapsed/refractory follicular lymphoma

High dose chemotherapy with autologous stem cell transplantation (ASCT) has been shown effective in the control of relapsed/refractory follicular lymphoma. We evaluate the long-term outcome of patients with relapsed or refractory follicular lymphoma treated with ASCT with in vivo purged progenitors cells. We report the long-term results of a prospective multicenter phase 2 trial on 124 relapsed/refractory follicular lymphoma patients with a program of anthracycline-based debulking chemotherapy, immunochemotherapy, mobilization of in vivo purged PBSC followed by ASCT. Median age was 52 years; 14% of patients had grade 3A histology. Debulking chemotherapy produced CR in 16% and PR in 71%, while 13% of patients progressed. After rituximab, cyclophosphamide, vincristine, prednisone (R-COP), CR was obtained in 60% and PR in 35%; 118 patients successfully mobilized PBSC and 117 proceeded to ASCT. The harvest in all the 32 molecularly informative patients was bcl-2 negative. TRM was 0%. The 5-yr PFS was 54% and the 5-yr OS was 83%. After a median f-up of 6.7 years (range 1.5-13.6), 53% are still in CR. These data show that prolonged PFS is achievable in relapsed/refractory patients with high dose autologous transplantation of in vivo purged progenitor cells