SCINTILLA A European project for the development of scintillation detectors and new technologies for nuclear security

Europe monitors transits using radiation detectors to prevent illicit trafficking of nuclear materials. The SCINTILLA project aims to develop a toolbox of innovative technologies designed to address different usage cases. This article will review the scope, approach, results of the first benchmark campaign and future plans of the SCINTILLA project.Comment: To appear on the Proceedings of the 13th ICATPP Conference on Astroparticle, Particle, Space Physics and Detectors for Physics Applications, Villa Olmo (Como, Italy), 23--27 October, 2013, to be published by World Scientific (Singapore

Delving in the loss landscape to embed robust watermarks into neural networks

International audienc

On the relation between the propagators of dual theories

In this paper, we show that the propagator of the dual of a general Proca-like theory, derived from the gauging iterative Noether Dualization Method, can be written by means of a simple relation between known propagators. This result is also a demonstration that the Lagrangian obtained by dualization describes the same physical particles as the ones present in the original theory at the expense of introducing new non-physical (ghosts) excitations.Comment: latex, 4 page

Bosonization and Duality in Arbitrary Dimensions: New Results

A generic massive Thirring Model in three space-time dimensions exhibits a correspondence with a topologically massive bosonized gauge action associated to a self-duality constraint, and we write down a general expression for this relationship. We also generalize this structure to $d$ dimensions, by adopting the so-called doublet approach, recently introduced. In particular, a non- conventional formulation of the bosonization technique in higher dimensions (in the spirit of $d=3$), is proposed and, as an application, we show how fermionic (Thirring-like) representations for bosonic topologically massive models in four dimensions may be built up.Comment: Revised version, to appear in Phys. Rev.

GdDOTAGA(C18)2: an efficient amphiphilic Gd(iii) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes

A new amphiphilic GdDOTA-like complex functionalized with two octadecyl chains was synthesised and incorporated into the bilayer of liposomes and dendrimersomes. (1)H NMR relaxometric studies and in vivo MRI experiments on mice bearing a syngeneic melanoma tumour have shown a great improvement in performance

IR ion spectroscopy in a combined approach with MS/MS and IM-MS to discriminate epimeric anthocyanin glycosides (cyanidin 3-O-glucoside and -galactoside)

Anthocyanins are widespread in plants and flowers, being responsible for their different colouring. Two representative members of this family have been selected, cyanidin 3-O-β-glucopyranoside and 3-O-β-galactopyranoside, and probed by mass spectrometry based methods, testing their performance in discriminating between the two epimers. The native anthocyanins, delivered into the gas phase by electrospray ionization, display a comparable drift time in ion mobility mass spectrometry (IM-MS) and a common fragment, corresponding to loss of the sugar moiety, in their collision induced dissociation (CID) pattern. However, the IR multiple photon dissociation (IRMPD) spectra in the fingerprint range show a feature particularly evident in the case of the glucoside. This signature is used to identify the presence of cyanidin 3-O-β-glucopyranoside in a natural extract of pomegranate. In an effort to increase any differentiation between the two epimers, aluminum complexes were prepared and sampled for elemental composition by FT-ICR-MS. CID experiments now display an extensive fragmentation pattern, showing few product ions peculiar to each species. More noteworthy is the IRMPD behavior in the OH stretching range showing significant differences in the spectra of the two epimers. DFT calculations allow to interpret the observed distinct bands due to a varied network of hydrogen bonding and relative conformer stability

A New Model for a Non-Linear Electromagnetic Model with Self-Interacting Photons

A new electromagnetism is still expected to be developed. Thus, under such a principle where nature works as a group, an electromagnetism beyond Maxwell is studied. It considers that light metric antecedes electric charge for founding the EM phenomena. Based on wholeness principle, Lorentz group and gauge invariance this electromagnetism sticked on light is proposed. Then, by electromagnetism it will be understood the physics derived from Lorentz group potential fields family (for simplicity other fields are not included). New electromagnetic fields, sectors, layers and regimes are developed. It yields a branch with transversal and longitudinal EM fields, granular and collective sectors, I-fields layers and four regimes (photonic, massive,neutral, charged) connected through a global photon. Their relationships are determined by a state equation identified as Global Maxwell equation. It contains new Gauss and Ampere laws, exclusive Faraday law for polarization and magnetization vectors, divergenceless magnetization vector having fields as sources, self-interacting photons mediated by a dimensionless coupling constant and other features. It is complemented by a Global Lorentz equation which besides the usual Lorentz force add forces depending on mass and on potential fields

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.

he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates. We previously reported a set of substituted 1,5-diarylpyrrole derivatives, along with their inhibitory activity toward COX enzymes. Several compounds proved to be highly selective COX-2 inhibitors and their affinity data were rationalized through docking simulations. In this paper, we describe the synthesis of new 1,5-diarylpyrrole derivatives that were assayed for their in vitro inhibitory effects toward COX isozymes. Among them, the ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-fluorophenyl]-1H-pyrrol-3- acetate (1d), which was the most potent and COX-2 selective compound, also showed a very interesting in vivo anti-inflammatory and analgesic activity, laying the foundations for developing new lead compounds that could be effective agents in the armamentarium for the management of inflammation and pain

First Report of CRISPR/Cas9 Gene Editing in Castanea sativa Mill

CRISPR/Cas9 has emerged as the most important tool for genome engineering due to its simplicity, design flexibility, and high efficiency. This technology makes it possible to induce point mutations in one or some target sequences simultaneously, as well as to introduce new genetic variants by homology-directed recombination. However, this approach remains largely unexplored in forest species. In this study, we reported the first example of CRISPR/Cas9-mediated gene editing in Castanea genus. As a proof of concept, we targeted the gene encoding phytoene desaturase (pds), whose mutation disrupts chlorophyll biosynthesis allowing for the visual assessment of knockout efficiency. Globular and early torpedo-stage somatic embryos of Castanea sativa (European chestnut) were cocultured for 5 days with a CRISPR/Cas9 construct targeting two conserved gene regions of pds and subsequently cultured on a selection medium with kanamycin. After 8 weeks of subculture on selection medium, four kanamycin-resistant embryogenetic lines were isolated. Genotyping of these lines through target Sanger sequencing of amplicons revealed successful gene editing. Cotyledonary somatic embryos were maturated on maltose 3% and cold-stored at 4°C for 2 months. Subsequently, embryos were subjected to the germination process to produce albino plants. This study opens the way to the use of the CRISPR/Cas9 system in European chestnut for biotechnological application