Efficacy and Safety of Artemether in the Treatment of Chronic Fascioliasis in Egypt: Exploratory Phase-2 Trials

Fasciola hepatica and F. gigantica are two liver flukes that parasitize herbivorous large size mammals (e.g., sheep and cattle), as well as humans. A single drug is available to treat infections with Fasciola flukes, namely, triclabendazole. Recently, laboratory studies and clinical trials in sheep and humans suffering from acute fascioliasis have shown that artesunate and artemether (drugs that are widely used against malaria) also show activity against fascioliasis. Hence, we were motivated to assess the efficacy and safety of oral artemether in patients with chronic Fasciola infections. The study was carried out in Egypt and artemether administered according to two different malaria treatment regimens. Cure rates observed with 6×80 mg and 3×200 mg artemether were 35% and 6%, respectively. In addition, high efficacy was observed when triclabendazole, the current drug of choice against human fascioliasis, was administered to patients remaining Fasciola positive following artemether treatment. Concluding, monotherapy with artemether does not represent an alternative to triclabendazole against fascioliasis, but its role in combination chemotherapy regimen remains to be investigated

Excess Molar Volumes & Excess Molecular Polarizatilons of Acetylacetone in Non-polar Solvents, Cyc1ohexane, Carbon Tetrachloride, Benzene & Dioxane

1084-108

Dielectric Polarization Measurements on Some β-Diketones & β-Ketoesters in Solution: Part II-Acetylacetone

427-43

Dielectric Polarization Measurements of Some β-Diketones & β-Ketoesters in Solutions: Part III-Dipole Moments of Benzoylacetone in Non-polar & Polar Solvents

607-60

Dielectric Polarization Measurements on Some β-Diketones & β-Ketoesters in Solution: Part I-Ethyl Acetoacetate

639-64

Molecular interactions of some picolines with benzene and carbon tetrachloride

Excess volumes, VE, of binary mixtures of α-picoline, β-picoline, and γ-picoline with benzene and carbon tetrachloride, and dipole moments, μ2, of picolines in these mixtures have been measured as a function of a composition at 20° to 50°C. The VE data are negative for all mixtures studied, and exhibit a minimum at a 1 : 1 molar ratio, suggesting that alternate molecules of the two components are probably involved in a packing pattern. The [math] data are greatest in the very dilute solutions and gradually decrease with increasing picoline concentration, indicating the applicability of Onsager’s model over the entire concentration range of picolines. The results are discussed in terms of dipole association which seems to be stronger in carbon tetrachloride solutions than in benzene solutions