Infections in the management of rheumatic diseases: An update

Patients with inflammatory rheumatic conditions have an increased risk of infection. While this could be the  result of the underlying disease, it may also be caused by the use of immunosuppressive therapies, which are  needed to treat these disorders. An increasing number of patients with rheumatoid arthritis or other  rheumatic  diseases are using biologic therapies (biologics) in addition to the synthetic diseasemodifying anti-rheumatic drugs. The side-effects and complications of these relatively new agents are unknown to many specialists (outside of rheumatology) and general practitioners. This article highlights updates on the most important infections encountered in the daily management of patients with rheumatic diseases and discusses  how these may be prevented

Infections in the management of rheumatic diseases: An update

Patients with inflammatory rheumatic conditions have an increased risk of infection. While this could be the  result of the underlying disease, it may also be caused by the use of immunosuppressive therapies, which are  needed to treat these disorders. An increasing number of patients with rheumatoid arthritis or other rheumatic diseases are using biologic therapies (biologics) in addition to the synthetic diseasemodifying anti-rheumatic drugs. The side-effects and complications of these relatively new agents are unknown to many specialists  (outside of rheumatology) and general practitioners. This article highlights updates on the most important  infections encountered in the daily management of patients with rheumatic diseases and discusses how these may be prevented

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management

Osteoarthritis (OA) is a highly prevalent condition and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations, and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligaments, cartilage and synovial tissue, which can be observed using radiography, ultrasonography or MRI. Hand OA is a heterogeneous disorder and is considered to be multifactorial in aetiology. This review provides an overview of the epidemiology, presentation and burden of hand OA, including an update on hand OA imaging (including the development of novel techniques), disease mechanisms and management. In particular, areas for which new evidence has substantially changed the way we understand, consider and treat hand OA are highlighted. For example, genetic studies, clinical trials and careful prospective imaging studies from the past 5 years are beginning to provide insights into the pathogenesis of hand OA that might uncover new therapeutic targets in disease