INTERACTION of ANGIOTENSIN PEPTIDES and of AMINO-ACIDS WITH PARA-NITROPHENYL ACETATE

ESCOLA PAULISTA MED,DEPT BIOPHYS & PHYSIOL,04023 São Paulo,BRAZILESCOLA PAULISTA MED,DEPT BIOPHYS & PHYSIOL,04023 São Paulo,BRAZILWeb of Scienc

IONIZATION of METHYL-DERIVATIVES of IMIDAZOLE, HISTIDINE, THYREOTROPIN RELEASING FACTOR, and RELATED COMPOUNDS

ESCOLA PAULISTA MED,DEPT BIOPHYS & PHYSIOL,04023 São Paulo,BRAZILESCOLA PAULISTA MED,DEPT BIOPHYS & PHYSIOL,04023 São Paulo,BRAZILWeb of Scienc

EFFECT of SUBSTRATE SIZE ON TONIN ACTIVITY

ESCOLA PAULISTA MED,DEPT BIOPHYS,BR-04023 São Paulo,SP,BRAZILESCOLA PAULISTA MED,DEPT BIOPHYS,BR-04023 São Paulo,SP,BRAZILWeb of Scienc

Antibodies against oxidized low-density lipoprotein in normolipidemic smokers

Oxidative low-density lipoprotein (LDL) damage caused by oxidants present in cigarette smoke may be involved in the pathogenesis of coronary heart disease,(1) but there is a controversy in published reports on this subject. Gouaze et al(2) demonstrated increased oxidizability in smokers, Siekmeier et al(3) could not confirm these results, and Chen and Loo(4) found an antioxidant property of cigarette smoke extract by measuring its effect on LDL oxidizability in vitro. We evaluated the contribution of cigarette smoking on LDL oxidizability and,plasma levels of antioxidized LDL in a well-defined healthy population of normolipidemic smokers. Blood samples were drawn a few minutes after subjects smoked 1 cigarette to ensure higher blood levels of oxidative products from cigarette smoke.(5).906651

REACTIVITY WITH PARA-NITROPHENYL ACETATE and INTERACTION BETWEEN the AMINO and IMIDAZOLE GROUPS of HISTIDINE and RELATED-COMPOUNDS

UNIV São Paulo,INST MED,São Paulo,SP,BRAZILWeb of Scienc

IONIZATION-CONSTANTS and THERMODYNAMIC PARAMETERS of HISTIDINE and DERIVATIVES

UNIV São Paulo,INST CHEM,SAN CARLOS,SP,BRAZILWeb of Scienc

INTRAMOLECULARLY QUENCHED FLUOROGENIC PEPTIDE-SUBSTRATES for HUMAN RENIN

UNIV FED MINAS GERAIS,DEPT BIOCHEM & IMMUNOL,BR-30000 BELO HORIZONTE,MG,BRAZILWeb of Scienc

Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein

Hormone replacement therapy (HRT) reduces cardiovascular risks, although the initiation of therapy may be associated with transient adverse ischemic and thrombotic events. Antibodies against heat shock protein (Hsp) and oxidized low density lipoprotein (LDL) have been found in atherosclerotic lesions and plasma of patients with coronary artery disease and may play an important role in the pathogenesis of atherosclerosis. The aim of the present study was to assess the effects of HRT on the immune response by measuring plasma levels of antibodies against Hsp 65 and LDL with a low and high degree of copper-mediated oxidative modification of 20 postmenopausal women before and 90 days after receiving orally 0.625 mg equine conjugate estrogen plus 2.5 mg medroxyprogesterone acetate per day. HRT significantly increased antibodies against Hsp 65 (0.316 ± 0.03 vs 0.558 ± 0.11) and against LDL with a low degree of oxidative modification (0.100 ± 0.01 vs 0.217 ± 0.02) (P<0.05 and P<0.001, respectively, ANOVA). The hormone-mediated immune response may trigger an inflammatory response within the vessel wall and potentially increase plaque burden. Whether or not this immune response is temporary or sustained and deleterious requires further investigation