324 research outputs found

    Repeated aeolian deflation during the Allerød/GI-1a-c in the coversand lowland of NW Belgium

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    The results of multi-disciplinary research carried out on the deposits of the Moerbeke "Driehoek" site, located along the northern bank of the extensive Moervaart palaeolake (NW Belgium), are presented. The multi-proxy study, including sedimentological (organic matter, calcium carbonate and grain-size) and botanical (pollen, macrofossils, NPP) analyses, provided evidence of repeated aeolian deflation during the Allerod. Our results demonstrate, in combination with evidence from other soil archives within the Moervaart area, that the Allerod period in NW Europe was sedimentologically much less stable than hitherto assumed, especially during the GI-1c2 event and middle Allerod. Some of the Allerod deflation events were caused by centennial abrupt climatic oscillations, such as the short but pronounced cold GI-1c2 event, while others were likely the result of intense forest fires or a combination of both. These observations call for a revision of the existing Lateglacial litho- and chronostratigraphic schemes for the sand-belt of northern Europe

    Charging mechanisms in persistent phosphors

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    The development of novel persistent phosphors is currently hampered by a limited understanding of the charging mechanism. Using x-ray absorption and thermoluminescence spectroscopy we evaluate the validity of recently proposed models for the charging mechanism

    Spatial Variations of Stochastic Noise Properties in GPS Time Series

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    The noise in position time series of 568 GPS (Global Position System) stations across North America with an observation span of ten years has been investigated using solutions from two processing centers, namely, the Pacific Northwest Geodetic Array (PANGA) and New Mexico Tech (NMT). It is well known that in the frequency domain, the noise exhibits a power-law behavior with a spectral index of around −1. By fitting various noise models to the observations and selecting the most likely one, we demonstrate that the spectral index in some regions flattens to zero at long periods while in other regions it is closer to −2. This has a significant impact on the estimated linear rate since flattening of the power spectral density roughly halves the uncertainty of the estimated tectonic rate while random walk doubles it. Our noise model selection is based on the highest log-likelihood value, and the Akaike and Bayesian Information Criteria to reduce the probability of over selecting noise models with many parameters. Finally, the noise in position time series also depends on the stability of the monument on which the GPS antenna is installed. We corroborate previous results that deep-drilled brace monuments produce smaller uncertainties than concrete piers. However, if at each site the optimal noise model is used, the differences become smaller due to the fact that many concrete piers are located in tectonic/seismic quiet areas. Thus, for the predicted performance of a new GPS network, not only the type of monument but also the noise properties of the region need to be taken into account

    RNA-binding protein CPEB1 remodels host and viral RNA landscapes.

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    Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in widespread alternative splicing (AS), shortening of 3' untranslated regions (3' UTRs) and lengthening of poly(A)-tails in host gene transcripts. We found that the host RNA-binding protein CPEB1 was highly induced after infection, and ectopic expression of CPEB1 in noninfected cells recapitulated infection-related post-transcriptional changes. CPEB1 was also required for poly(A)-tail lengthening of viral RNAs important for productive infection. Strikingly, depletion of CPEB1 reversed infection-related cytopathology and post-transcriptional changes, and decreased productive HCMV titers. Host RNA processing was also altered in herpes simplex virus-2 (HSV-2)-infected cells, thereby indicating that this phenomenon might be a common occurrence during herpesvirus infections. We anticipate that our work may serve as a starting point for therapeutic targeting of host RNA-binding proteins in herpesvirus infections
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