A Delft family portrait (1638) by Jan Daemen Cool

Since 1935 the Royal Museum of Fine Arts in Antwerp has held an unusually animated family portrait featuring a couple and their fijive children, including twins, which dates from 1638. The recent restoration of the painting has led to technical and art-historical research, with new insights into the history of the creation of this painting. This has resulted in the discovery of the identity of the sitters. The painting was originally probably twenty centimetres wider on the right-hand side, but is otherwise still in good condition. On the basis of the provenance information, marriage and death certifijicates and notarial archives, it was possible to discover the family’s identity. The painting shows Cornelis van der Heijde (1601/2-1638), a Roman Catholic doctor from Delft, his wife Ariaentgen de Buijser (1610-1677) and their daughters – including twins – Aechken (d. 1652), Pieternelle (d. 1661), Digna (d. 1672), Anna (d. 1681) and an unknown child who died in 1639 (probably Adriaen or Ariaentgen). The painting was made only a few months after the birth of the twins, probably in the autumn of 1638. Cornelis van der Heijde died in November 1638. It is not clear whether his portrait was painted while he was still alive or made after an earlier portrait. Rudi Ekkart convincingly attributed this family portrait to the Rotterdam painter Jan Daemen Cool (ca. 1589-1660). The form of the inscriptions and the characteristic rendering of the hands, eyes and mouths all support this attribution. It is true that Cool was trained in Delft by Michiel van Mierevelt, but until now we have known of no activities by him in that city after 1614. As far as we know, this is the only portrait that Cool made for a Catholic client. It forms an interesting pendant to the portrait of the likewise Catholic Van der Dussen family by Hendrick Cornelisz van Vliet of 1640 (Prinsenhof, Delft). In 1660 one of the portrayed sons, Cornelis, would go on to marry Digna van der Heijde, one of the daughters in the discussed family portrait by Jan Daemen Cool from 1638

Development of a theory-guided pan-European computer-assisted safer sex intervention Citation for published version (APA): Development of a theory-guided pan-European computer-assisted safer sex intervention

Summary HIV is a growing public health problem in Europe, with men-having-sex-with-men and migrants from endemic regions as the most affected key populations. More evidence on effective behavioral interventions to reduce sexual risk is needed. This article describes the systematic development of a theoryguided computer-assisted safer sex intervention, aiming at supporting people living with HIV in sexual risk reduction. We applied the Intervention Mapping (IM) protocol to develop this counseling intervention in the framework of a European multicenter study. We conducted a needs assessment guided by the information-motivation-behavioral (IMB) skills model, formulated change objectives and selected theory-based methods and practical strategies, i.e. interactive computer-assisted modules as supporting tools for provider-delivered counseling. Theoretical foundations were the IMB skills model, social cognitive theory and the transtheoretical model, complemented by dual process models of affective decision making to account for the specifics of sexual behavior. The counseling approach for delivering three individual sessions was tailored to participants' needs and contexts, adopting elements of motivational interviewing and cognitive-behavioral therapy. We implemented and evaluated the intervention using a randomized controlled trial combined with a process evaluation. IM provided a useful framework for developing a coherent intervention for heterogeneous target groups, which was feasible and effective across the culturally diverse settings. This article responds to the need for transparent descriptions of the development and content of evidence-based behavior change interventions as potential pillars of effective combination prevention strategies

Stable metabolic disease on FDG-PET provides information on response to endocrine therapy for breast cancer

To assess whether outcome in advanced breast cancer patients is related to metabolic response to endocrine therapy determined by FDG---PET.status: publishe

Medication review using a Systematic Tool to Reduce Inappropriate Prescribing (STRIP) in adults with an intellectual disability: A pilot study

A Systematic Tool to Reduce Inappropriate Prescribing (STRIP), which includes the Screening Tool to Alert doctors to Right Treatment (START) and the Screening Tool of Older Peoples' Prescriptions (STOPP), has recently been developed in the Netherlands for older patients with polypharmacy in the general population. Active involvement of the patient is part of this systematic multidisciplinary medication review. Although annual review of pharmacotherapy is recommended for people with an intellectual disability (ID), a specific tool for this population is not yet available. Besides, active involvement can be compromised by ID. Therefore, the objective of this observational pilot study was to evaluate the process of medication review using STRIP in adults with an ID living in a centralized or dependent setting and the identification of drug-related problems using this tool. The study was performed in three residential care organizations for ID. In each organization nine clients with polypharmacy were selected by an investigator (a physician in training to become a specialized physician for individuals with an ID) for a review using STRIP. Clients as well as their legal representatives (usually a family member) and professional caregivers were invited to participate. Reviews were performed by an investigator together with a pharmacist. First, to evaluate the process time-investments of the investigator and the pharmacist were described. Besides, the proportion of reviews in which a client and/or his legal representative participated was calculated as well as the proportion of professional caregivers that participated. Second, to evaluate the identification of drug-related problems using STRIP, the proportion of clients with at least one drug-related problem was calculated. Mean time investment was 130 minutes for the investigator and 90 minutes for the pharmacist. The client and/or a legal representatives were present during 25 of 27 reviews (93%). All 27 professional caregivers (100%) were involved. For every client included at least one drug related problem was identified. In total 127 drug-related problems were detected, mainly potentially inappropriate or unnecessary drugs. After six months, 15.7% of the interventions were actually implemented. Medication review using STRIP seems feasible in adults with an ID and identifies drug related problems. However, in this pilot study the implementation rate of suggested interventions was low. To improve the implementation rate, the treating physician should be involved in the review process. Besides, specific adaptations to STRIP to address drug related problems specific for this population are required. (c) 2016 Elsevier Ltd. All rights reserved

Medication review using a Systematic Tool to Reduce Inappropriate Prescribing (STRIP) in adults with an intellectual disability: A pilot study

A Systematic Tool to Reduce Inappropriate Prescribing (STRIP), which includes the Screening Tool to Alert doctors to Right Treatment (START) and the Screening Tool of Older Peoples' Prescriptions (STOPP), has recently been developed in the Netherlands for older patients with polypharmacy in the general population. Active involvement of the patient is part of this systematic multidisciplinary medication review. Although annual review of pharmacotherapy is recommended for people with an intellectual disability (ID), a specific tool for this population is not yet available. Besides, active involvement can be compromised by ID. Therefore, the objective of this observational pilot study was to evaluate the process of medication review using STRIP in adults with an ID living in a centralized or dependent setting and the identification of drug-related problems using this tool. The study was performed in three residential care organizations for ID. In each organization nine clients with polypharmacy were selected by an investigator (a physician in training to become a specialized physician for individuals with an ID) for a review using STRIP. Clients as well as their legal representatives (usually a family member) and professional caregivers were invited to participate. Reviews were performed by an investigator together with a pharmacist. First, to evaluate the process time-investments of the investigator and the pharmacist were described. Besides, the proportion of reviews in which a client and/or his legal representative participated was calculated as well as the proportion of professional caregivers that participated. Second, to evaluate the identification of drug-related problems using STRIP, the proportion of clients with at least one drug-related problem was calculated. Mean time investment was 130 minutes for the investigator and 90 minutes for the pharmacist. The client and/or a legal representatives were present during 25 of 27 reviews (93%). All 27 professional caregivers (100%) were involved. For every client included at least one drug-related problem was identified. In total 127 drug-related problems were detected, mainly potentially inappropriate or unnecessary drugs. After six months, 15.7% of the interventions were actually implemented.Medication review using STRIP seems feasible in adults with an ID and identifies drug-related problems. However, in this pilot study the implementation rate of suggested interventions was low. To improve the implementation rate, the treating physician should be involved in the review process. Besides, specific adaptations to STRIP to address drug-related problems specific for this population are required