New optical sensing system applied to taut wire based straightness measurement

In modern manufacturing industry, precision components are typically produced on Computer Numerical Controlled (CNC) machine tools which translate their accuracy onto machined parts. This accuracy is affected by a set of different motion errors caused by inherent imperfections in the design and build of the machine, variations in the local environment such as temperature, the cutting process itself and human factors. The reduction of these effects is achieved primarily through design improvements and error compensation techniques. The latter requires detailed knowledge about the existing errors in order to deal with them effectively. This thesis describes a novel sensor system for measurement of errors caused by deviation in the straightness of Cartesian axes present in the structural loop of most machine tools. Currently there are very few methods available to measure straightness directly, each having advantages and disadvantages when considering simplicity, accuracy and affordability. The proposed system uses a taut wire reference with a novel sensor, a two-point technique for reference error cancellation and software to enable fast and accurate measurement of straightness between any two points of the measured machine’s working volume. The standout features of the sensing system include ultra-low cost and high performance when compared with existing state-of-the-art systems. It is capable of measuring a straightness error as low as 3μm and takes only 2s of dwell time between readings, while laser interferometer requires 4s to perform averaging when measuring the same error. Existing taut wire microscopy is limited by 10-20μm of measured error depending on optics quality and manual reading takes at least 5s to minimise the human error. Setup time is also different – the new system saves 15 minutes time on 2m axis and more on longer lengths compared the laser due to simpler reference alignment procedure. Theoretical analysis and practical implementation are followed by detailed performance evaluation experiments carried out under typical manufacturing conditions comprising different machine tools, different axes, measured errors, environmental effects and alternative measuring equipment. Tests cover aspects of accuracy, repeatability and overall system stability providing a complete picture of the system’s capability and the method’s potential which is also supported by uncertainty analysis. In addition to defining setup and measuring procedures, a user-friendly software interface is described and its main units are explained with respect to overall measurement efficiency and setup fault detection

Establishing low-energy sequential decomposition pathways of leucine enkephalin and its N- and C-terminus fragments using multiple-resonance CID in quadrupolar ion guide

The simultaneous resonant low-energy excitation of leucine enkephalin and its fragment ions was demonstrated in a collision cell of the multipole-quadrupole time-of-flight instrument. Using low-amplitude multiple-resonance excitation CID, we were able to show the exclusive sequential fragmentation of N- and C-terminus fragments all the way to the final fragments—immonium ions of phenylalanine or tyrosine. In this CID mode the single-channel dissociation of each new generation of fragments followed the lowest energy decomposition pathways observable on the time scale of our experiment. Up to six generations of sequential dissociation were carried out in multiple-resonance CID experiments. The direct qualitative comparison of fragmentation of axial-acceleration versus resonant (radial) CID was performed in the same instrument. In both activation methods, fragmentation patterns suggested complex decomposition mechanisms attributable to dynamic competition between sequential and parallel dissociation channels

The Influence of K4[Fe(CN)6] Aerosol on the Flame Speed of Methane-air Flame

AbstractThe influence of 1% aerosol of the water solution of potassium ferrocyanide K4[Fe(CN)6] on the flame speed of stoichoimetric methane- air flame, stabilized over the Mache-Hebra burner, has been studied experimentally and by computer simulation. The flame speed was measured at atmospheric pressure and the temperature 93°C. Addition of the aerosol of the water solution of potassium ferrocyanide results in significantly greater reduction of the flame speed of stoichiometric methane-air flame, compared to aerosol addition without the salt. Modeling the flame speed with the mechanism GRI-Mech 3.0 shows this effect to be caused by the presence of potassium atoms in the composition of this salt. The results obtained account for effectiveness of applying fine aerosol of the water solution of K4[Fe(CN)6] in extinguishing fires

New approach to the visualization of international scientific collaboration

Chinchilla-Rodríguez, Z., Vargas-Quesada, B., Hassan-Montero, Y., González-Molina, A., Moya-Anegón, F. New approach to the visualization of international scientific collaboration. Information Visualization, 9 (4): 277-287, Winter 2010. DOI: 10.1057/ivs.2009.31In this study, visual representations are created in order to analyze different aspects of scientific collaboration at the international level. The main objective is to identify the international facet of research by following the flow of knowledge as expressed by the number of scientific publications, and then establishes the main geographical axes of output, showing the interrelationships of the domain, the intensity of these relations, and how the different types of collaboration are reflected in terms of visibility. Thus, the methodology has a twofold application, allowing us to detect significant differences that help characterize patterns of behaviour of a geographical system of output, along with the generation of representations that serve as interfaces for domain analysis and information retrieval.Peer reviewe

Influence of surface modification of nitinol with silicon using plasma-immersion ion implantation on the alloy corrosion resistance in artificial physiological solutions

Cyclic voltammetry and potentiostatic polarization have been applied to study electrochemical behavior and to determine corrosion resistance of nitinol, which surface was modified with silicon using plasma-immersion ion implantation, in 0.9% NaCl solution and in artificial blood plasma. It was found out that continuous, and also homogeneous in composition, thin Si-containing layers are resistant to corrosion damage at high positive potentials in artificial physiological solutions due to formation of stable passive films. Breakdown potential Eb of Si-modified NiTi depends on the character of silicon and Ni distribution at the alloy surface, Eb values amounted to 0.9–1.5 V (Ag/AgCl/KCl sat.) for the alloy samples with continuous Si-containing surface layers and with decreased Ni surface concentration

New insights into the hypothalamic–pituitary–thyroid axis:a transcriptome- and proteome-wide association study

Introduction: Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues. They are regulated via the hypothalamic–pituitary–thyroid (HPT) axis and have a heritable component. Using genetic information, we applied tissue-specific transcriptome-wide association studies (TWAS) and plasma proteome-wide association studies (PWAS) to elucidate gene products related to thyrotropin (TSH) and free thyroxine (FT4) levels. Results: TWAS identified 297 and 113 transcripts associated with TSH and FT4 levels, respectively (25 shared), including transcripts not identified by genome-wide association studies (GWAS) of these traits, demonstrating the increased power of this approach. Testing for genetic colocalization revealed a shared genetic basis of 158 transcripts with TSH and 45 transcripts with FT4, including independent, FT4-associated genetic signals within the CAPZB locus that were differentially associated with CAPZB expression in different tissues. PWAS identified 18 and ten proteins associated with TSH and FT4, respectively (HEXIM1 and QSOX2 with both). Among these, the cognate genes of five TSH- and 7 FT4-associated proteins mapped outside significant GWAS loci. Colocalization was observed for five plasma proteins each with TSH and FT4. There were ten TSH and one FT4-related gene(s) significant in both TWAS and PWAS. Of these, ANXA5 expression and plasma annexin A5 levels were inversely associated with TSH (PWAS: P = 1.18 × 10−13, TWAS: P = 7.61 × 10−12 (whole blood), P = 6.40 × 10−13 (hypothalamus), P = 1.57 × 10−15 (pituitary), P = 4.27 × 10−15 (thyroid)), supported by colocalizations. Conclusion: Our analyses revealed new thyroid function-associated genes and prioritized candidates in known GWAS loci, contributing to a better understanding of transcriptional regulation and protein levels relevant to thyroid function.</p

Structural phase states in nickel-titanium surface layers doped with silicon by plasma immersion ion implantation

The paper reports on a study of NiTi-based alloys used for manufacturing self-expanding intravascular stents to elucidate how the technological modes of plasma immersion ion implantation with silicon influence the chemical an

Plasma immersion ion implantation for surface treatment of complex branched structures

The paper presents experimental results demonstrating the capabilities of plasma immersion ion implantation of silicon (Si) for surface treatment of complex branched structures such are self-expanding intravascular nickel-titanium (NiTi) stents. Using NiTi stents of diameter 4 and 8 mm, it is shown that plasma immersion ion implantation can provide rather homogeneous doping of their outer and inner surfaces with Si atoms. Also presented are research data on the processes that determine the thickness, composition, and structure of surface layers subjected to this type of treatment

Twenty-Five Novel Loci for Carotid Intima-Media Thickness:A Genome-Wide Association Study in &gt;45 000 Individuals and Meta-Analysis of &gt;100 000 Individuals

OBJECTIVE: Carotid artery intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and the identification of additional susceptibility loci furthers our knowledge on the genetic architecture underlying atherosclerosis. Approach and Results: We performed 3 genome-wide association studies in 45 185 participants from the UK Biobank study who underwent cIMT measurements and had data on minimum, mean, and maximum thickness. We replicated 15 known loci and identified 20 novel loci associated with cIMT at P100 000 individuals identified 25 novel loci associated with cIMT providing insights into genes and tissue-specific regulatory mechanisms of proatherosclerotic processes. We found evidence for shared biological mechanisms with cardiovascular diseases