THE FAMILY OF AHMOSE, THE OWNER OF THEBAN TOMB 224 [NEW DATA]

عائلة إعح-مس ،صاحب المقبرة الطيبية 224 [Ar] طالما بنيت الحضارة الإنسانية على أساس الأسرة- فقد تكونت الأسرة النواة من الزوج والزوجة والأطفال. أما الأسرة -الممتدة- فتتكون من من خلال وجود علاقات- عائلية مباشرة أو غير مباشرة، مثل الأجداد والأحفاد- الأعمام والعمات- وبنات الأخت وأبناء الأخ وأبناء العم كلها كأمثلة على الأقارب. تحتوي هذه المقالة على معلومات جديدة عن عائلة إعح-مس - المشرف على الحبوب الذي عمل في عهد تحتمس الثالث (الأسرة 18)- وصاحب مقبرة طيبة TT 224، التي تقع في الجبانة السفلية على الضفة الغربية لطيبة- في الشيخ عبد القرنة. و نظرًا لعدم نشر المقبرةTT 224 إلى الان أو فحصها مطلقًا أو الكشف عن مناظر جدرانها، بالإضافة إلى الحالة -السيئة للمقبرة- والجدران المحفوظة بشكل سيء- ونقص المصادر التاريخية عن إعح-مس- فلا يعرف العلماء الحاليون سوى القليل عن حياته وعائلته ومسيرته المهنية. نتيجة لذلك-سيتم إعادة بناء عائلة إعح-مس والتعرف عليهم -باستخدام مناظر ونقوش لم تنشر من قبل من TT 224 بالإضافة إلى الإستعانة بالمناظر والنقوش الخاصة بمقابر أبنائه-وقد كشفت هذه المصادر، إلى جانب جهود فريق الترميم المصري لتنظيف وترميم المقبرة 224- عن معلومات جديدة حول أفراد شجرة عائلة إعح-مس- مثل الآباء والأشقاء والزوجات والبنات والأبناء- مع التعريف بألقابهم إن أمكن-. كل ذلك يساعد على معرفة إعح-مس وعائلته ومكانته- الاجتماعية ومسيرته المهنية. نتيجة لذلك، يهدف هذا البحث إلى إلقاء مزيد من الضوء على السياق التاريخي وأهمية عائلة مالك مقبرة طيبة 224- كما تبحث المقالة أيضًا في أبناء إعح- مس- من صلبه -بالإضافة إلى -العلاقة بين إعح-مس و سن نفر-ابنه المزعوم طبقا لمعظم المراجع الأساسية. [EN] The family has always been the cornerstone of human civilization. The nuclear family is comprised of the husband, wife, and children. The extended family consists of direct and indirect familial relations, such as grandparents and grandchildren. Uncles, aunts, nieces, nephews, and cousins are all examples of relatives. This article contains new information on Ahmose\u27s family, the grainers\u27 superintendent who served under Thutmose III\u27s reign (18th dynasty), and the owner of Theban Tomb (TT 224), which is located in the lower necropolis on Thebes\u27 western bank, at Sheikh ʿAbd el Qurna. Because of the tomb\u27s current condition, which includes its poorly preserved walls, the fact that it has never been published or examined, and the lack of Ahmose’s historical documents, current scholars know very little about his life, family, and career. Ahmose\u27s family members -will be identified, and their relationship reconstructed, using previously unpublished scenes and inscriptions from TT 224, which the Egyptian conservation team cleaned and restored, as well as scenes and inscriptions from his sons\u27 tombs. These sources have revealed new information about Ahmose\u27s family tree, including his parents, siblings, wives, daughters, and sons, along with their titles. As a result, this research aims to provide more context about Ahmose\u27s historical position and rank and shed more light on the significance of his family. The article also looks into Ahmose\u27s biological son and the relationship between Ahmose and his alleged son, Sennefer, as indicated by primary sources

THE FAMILY OF AHMOSE, THE OWNER OF THEBAN TOMB 224 [NEW DATA]

عائلة إعح-مس ،صاحب المقبرة الطيبية 224 [AR] طالما بنيت الحضارة الإنسانية على أساس الأسرة- فقد تكونت الأسرة النواة من الزوج والزوجة والأطفال. أما الأسرة -الممتدة- فتتكون من من خلال وجود علاقات- عائلية مباشرة أو غير مباشرة، مثل الأجداد والأحفاد- الأعمام والعمات- وبنات الأخت وأبناء الأخ وأبناء العم كلها كأمثلة على الأقارب. تحتوي هذه المقالة على معلومات جديدة عن عائلة إعح-مس - المشرف على الحبوب الذي عمل في عهد تحتمس الثالث (الأسرة 18)- وصاحب مقبرة طيبة TT 224، التي تقع في الجبانة السفلية على الضفة الغربية لطيبة- في الشيخ عبد القرنة. و نظرًا لعدم نشر المقبرةTT 224 إلى الان أو فحصها مطلقًا أو الكشف عن مناظر جدرانها، بالإضافة إلى الحالة -السيئة للمقبرة- والجدران المحفوظة بشكل سيء- ونقص المصادر التاريخية عن إعح-مس- فلا يعرف العلماء الحاليون سوى القليل عن حياته وعائلته ومسيرته المهنية. نتيجة لذلك-سيتم إعادة بناء عائلة إعح-مس والتعرف عليهم -باستخدام مناظر ونقوش لم تنشر من قبل من TT 224 بالإضافة إلى الإستعانة بالمناظر والنقوش الخاصة بمقابر أبنائه-وقد كشفت هذه المصادر، إلى جانب جهود فريق الترميم المصري لتنظيف وترميم المقبرة 224- عن معلومات جديدة حول أفراد شجرة عائلة إعح-مس- مثل الآباء والأشقاء والزوجات والبنات والأبناء- مع التعريف بألقابهم إن أمكن-. كل ذلك يساعد على معرفة إعح-مس وعائلته ومكانته- الاجتماعية ومسيرته المهنية. نتيجة لذلك، يهدف هذا البحث إلى إلقاء مزيد من الضوء على السياق التاريخي وأهمية عائلة مالك مقبرة طيبة 224- كما تبحث المقالة أيضًا في أبناء إعح- مس- من صلبه -بالإضافة إلى -العلاقة بين إعح-مس و سن نفر-ابنه المزعوم طبقا لمعظم المراجع الأساسية. [EN] The family has always been the cornerstone of human civilization. The nuclear family is comprised of the husband, wife, and children. The extended family consists of direct and indirect familial relations, such as grandparents and grandchildren. Uncles, aunts, nieces, nephews, and cousins are all examples of relatives. This article contains new information on Ahmose's family, the grainers' superintendent who served under Thutmose III's reign (18th dynasty), and the owner of Theban Tomb (TT 224), which is located in the lower necropolis on Thebes' western bank, at Sheikh ʿAbd el Qurna. Because of the tomb's current condition, which includes its poorly preserved walls, the fact that it has never been published or examined, and the lack of Ahmose’s historical documents, current scholars know very little about his life, family, and career. Ahmose's family members -will be identified, and their relationship reconstructed, using previously unpublished scenes and inscriptions from TT 224, which the Egyptian conservation team cleaned and restored, as well as scenes and inscriptions from his sons' tombs. These sources have revealed new information about Ahmose's family tree, including his parents, siblings, wives, daughters, and sons, along with their titles. As a result, this research aims to provide more context about Ahmose's historical position and rank and shed more light on the significance of his family. The article also looks into Ahmose's biological son and the relationship between Ahmose and his alleged son, Sennefer, as indicated by primary sources

A dual strategy to improve psychotic patients\u27 compliance using sustained release quetiapine oral disintegrating tablets

Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5%), croscarmellose sodium (2%) and mannitol (50%); it was then lyophilized into ODT in a mass ratio of 1:2 respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs

Enhancing photocatalytic degradation of the cyanotoxin microcystin-LR with the addition of sulfate-radical generating oxidants.

This study investigated the coupling of sulfate radical generating oxidants, (persulfate, PS and peroxymonosulfate, PMS) with TiO2 photocatalysis for the degradation of microcystin-LR (MC-LR). Treatment efficiency was evaluated by estimating the electrical energy per order (EEO). Oxidant addition at 10 mg/L reduced the energy requirements of the treatment by 60% and 12% for PMS and PS, respectively compared with conventional photocatalysis. Quenching studies indicated that both sulfate and hydroxyl radicals contributed towards the degradation of MC-LR for both oxidants, while Electron Paramagnetic Resonance (EPR) studies confirmed that the oxidants prolonged that lifetime of both radicals (concentration maxima shifted from 10 to 20min), allowing for bulk diffusion and enhancing cyanotoxin removal. Structural identification of transformation products (TPs) formed during all treatments, indicated that early stage degradation of MC-LR occurred mainly on the aromatic ring and conjugated carbon double bonds of the ADDA amino acid. In addition, simultaneous hydroxyl substitution of the aromatic ring and the conjugated double carbon bonds of ADDA (m/z= 1027.5) are reported for the first time. Oxidant addition also increased the rates of formation/degradation of TPs and affected the overall toxicity of the treated samples. The detoxification and degradation order of the treatments was UVA/TiO2/PMS > UVA/TiO2/PS>> UVA/TiO2

Synthesis of C2-Symmetrical Bis-(β-Enamino-Pyran-2,4-dione) Derivative Linked via 1,6-Hexylene Spacer: X-ray Crystal Structures, Hishfeld Studies and DFT Calculations of Mono- and Bis-(Pyran-2,4-diones) Derivatives

The synthesis of C2-symmetrical bis(β-enamino-pyran-2,4-dione) derivative 3 connected via 1,6-hexylene linker was reported for the first time. X-ray structures and Hirshfeld studies of the new bis- β-enamino-pyran-2,4-dione derivative 3 along with two structurally related pyran-2,4-dione derivatives 2a,b were discussed. A comparative analysis of the different intermolecular contacts affecting the crystal stability was presented. Generally, the H…H, O…H, and H…C interactions are common in all compounds and are considered the most abundant contacts. In addition, DFT calculations were used to compute the electronic properties as well as the 1H and 13C NMR spectra of the studied systems. All compounds (except 3) are polar where 2a (3.540 Debye) has a higher dipole moment than 2b (2.110 Debye). The NMR chemical shifts were calculated and excellent correlations between the calculated and experimental data were obtained (R2 = 0.93–0.94)

Straightforward One-Pot Synthesis of New 4-Phenyl-1,2,5,6-tetraazafluoranthen-3(2H)-one Derivatives: X-ray Single Crystal Structure and Hirshfeld Analyses

A straightforward one-pot route for the synthesis of a new 4-phenyl-1,2,5,6-tetraazafluoranthen-3(2H)-one is reported form the direct hydrazinolysis of triketo ester and hydrazine hydrate in ethanol. 4-Phenyl-1,2,5,6-tetraazafluoranthen-3(2H)-one was subjected to aza-Michael addition and N-alkylation on reaction with a set of alkylating agents in the presence of K2CO3. Hydrazinolysis of 4-phenyl-1,2,5,6-tetraazafluoranthen-3(2H)-one ester to hydrazide and conversion of hydrazide to thiosemicarbazide were successful. X-Ray single crystals analysis and 1H, 13C NMR were used for unambiguous structure confirmation. The O…H, N…H, C…N and C…C in 2, and the N…H, C…N, C…C, C…O and H…H interactions in 6 are the most important in the molecular packing based on Hirshfled analysis. Moreover, the presence of short C…C and C…N contacts in both compounds revealed the presence of π–π stacking interactions

Synthesis and Anti-Proliferative Assessment of Triazolo-Thiadiazepine and Triazolo-Thiadiazine Scaffolds

A series of triazolo-thiadiazepines 4a–k were synthesized with excellent yields using dehydrated PTSA as a catalyst in toluene. Two triazolo-thiadiazines were obtained; 8a was formed directly by reflux in ethanol, whereas, PTSA promoted the formation of 8b. The molecular structure of the formed triazolo-thiadiazepines is identical to the imine-form 4a–k and not the enamine-tautomer 6a–k. The structures of the newly synthesized triazolo-thiadiazepines 4a–k and triazolo-thiadiazines 8a–b were elucidated using NMR (1H, and 13C), 2D NMR, HRMS, and X-ray single crystal. Furthermore, 4a was deduced using X-ray single crystal diffraction analysis. These new thiadiazepine hits represent an optimized series of previously synthesized indole-triazole derivatives for the inhibition of EGFR. The cytotoxicity activity against two cancer cell lines including human liver cancer (HEPG-2) and breast cancer (MCF-7) was promising, with IC50 between 12.9 to 44.6 µg/mL and 14.7 to 48.7 µg/mL for the tested cancer cell lines respectively, compared to doxorubicin (IC50 4.0 µg/mL). Docking studies revealed that the thiadiazepine scaffold presented a suitable anchor, allowing good interaction of the various binding groups with the enzyme binding regions and sub-pockets