16,002 research outputs found
A probability-conserving cross-section biasing mechanism for variance reduction in Monte Carlo particle transport calculations
In Monte Carlo particle transport codes, it is often important to adjust
reaction cross sections to reduce the variance of calculations of relatively
rare events, in a technique known as non-analogous Monte Carlo. We present the
theory and sample code for a Geant4 process which allows the cross section of a
G4VDiscreteProcess to be scaled, while adjusting track weights so as to
mitigate the effects of altered primary beam depletion induced by the cross
section change. This makes it possible to increase the cross section of nuclear
reactions by factors exceeding 10^4 (in appropriate cases), without distorting
the results of energy deposition calculations or coincidence rates. The
procedure is also valid for bias factors less than unity, which is useful, for
example, in problems that involve computation of particle penetration deep into
a target, such as occurs in atmospheric showers or in shielding
An orthologue of bacteroides fragilis NanH is the principal sialidase in tannerella forsythia
Sialidase activity is a putative virulence factor of the anaerobic periodontal pathogen Tannerella forsythia, but it is uncertain which genes encode this activity. Characterization of a putative sialidase, SiaHI, by others, indicated that this protein alone may not be responsible for all of the sialidase activity. We describe a second sialidase in T. forsythia (TF0035), an orthologue of Bacteroides fragilis NanH, and its expression in Escherichia coli. Sialidase activity of the expressed NanH was confirmed by using 2′-(4-methylumbelliferyl)-α-d-N-acetylneuraminic acid as a substrate. Biochemical characterization of the recombinant T. forsythia NanH indicated that it was active over a broad pH range, with optimum activity at pH 5.5. This enzyme has high affinity for 2′-(4-methylumbelliferyl)-α-d-N-acetylneuraminic acid (Km of 32.9 ± 10.3 μM) and rapidly releases 4-methylumbelliferone (Vmax of 170.8 ± 11.8 nmol of 4-methylumbelliferone min−1 mg of protein−1). E. coli lysates containing recombinant T. forsythia NanH cleave sialic acid from a range of substrates, with a preference for α2-3 glycosidic linkages. The genes adjacent to nanH encode proteins apparently involved in the metabolism of sialic acid, indicating that the NanH sialidase is likely to be involved in nutrient acquisition
Fundamental properties and applications of quasi-local black hole horizons
The traditional description of black holes in terms of event horizons is
inadequate for many physical applications, especially when studying black holes
in non-stationary spacetimes. In these cases, it is often more useful to use
the quasi-local notions of trapped and marginally trapped surfaces, which lead
naturally to the framework of trapping, isolated, and dynamical horizons. This
framework allows us to analyze diverse facets of black holes in a unified
manner and to significantly generalize several results in black hole physics.
It also leads to a number of applications in mathematical general relativity,
numerical relativity, astrophysics, and quantum gravity. In this review, I will
discuss the basic ideas and recent developments in this framework, and
summarize some of its applications with an emphasis on numerical relativity.Comment: 14 pages, 2 figures. Based on a talk presented at the 18th
International Conference on General Relativity and Gravitation, 8-13 July
2007, Sydney, Australi
Energy-weighted density matrix embedding of open correlated chemical fragments
We present a multi-scale approach to efficiently embed an ab initio
correlated chemical fragment described by its energy-weighted density matrices,
and entangled with a wider mean-field many-electron system. This approach,
first presented in Phys. Rev. B, 98, 235132 (2018), is here extended to account
for realistic long-range interactions and broken symmetry states. The scheme
allows for a systematically improvable description in the range of correlated
fluctuations out of the fragment into the system, via a self-consistent
optimization of a coupled auxiliary mean-field system. It is discussed that the
method has rigorous limits equivalent to existing quantum embedding approaches
of both dynamical mean-field theory, as well as density matrix embedding
theory, to which this method is compared, and the importance of these
correlated fluctuations is demonstrated. We derive a self-consistent local
energy functional within the scheme, and demonstrate the approach for Hydrogen
rings, where quantitative accuracy is achieved despite only a single atom being
explicitly treated.Comment: 14 pages, 8 figure
Quantifying structural damage from self-irradiation in a plutonium superconductor
The 18.5 K superconductor PuCoGa5 has many unusual properties, including
those due to damage induced by self-irradiation. The superconducting transition
temperature decreases sharply with time, suggesting a radiation-induced Frenkel
defect concentration much larger than predicted by current radiation damage
theories. Extended x-ray absorption fine-structure measurements demonstrate
that while the local crystal structure in fresh material is well ordered, aged
material is disordered much more strongly than expected from simple defects,
consistent with strong disorder throughout the damage cascade region. These
data highlight the potential impact of local lattice distortions relative to
defects on the properties of irradiated materials and underscore the need for
more atomic-resolution structural comparisons between radiation damage
experiments and theory.Comment: 7 pages, 5 figures, to be published in PR
Tawney and the third way
From the 1920s to the 1950s R. H. Tawney was the most influential socialist thinker in Britain. He articulated an ethical socialism at odds with powerful statist and mechanistic traditions in British socialist thinking. Tawney's work is thus an important antecedent to third way thinking. Tawney's religiously-based critique of the morality of capitalism was combined with a concern for detailed institutional reform, challenging simple dichotomies between public and private ownership. He began a debate about democratizing the enterprise and corporate governance though his efforts fell on stony ground. Conversely, Tawney's moralism informed a whole-hearted condemnation of market forces in tension with both his concern with institutional reform and modern third way thought. Unfortunately, he refused to engage seriously with emergent welfare economics which for many social democrats promised a more nuanced understanding of the limits of market forces. Tawney's legacy is a complex one, whose various elements form a vital part of the intellectual background to current third way thinking
Self-contained Kondo effect in single molecules
Kondo coupling of f and conduction electrons is a common feature of
f-electron intermetallics. Similar effects should occur in carbon ring
systems(metallocenes). Evidence for Kondo coupling in Ce(C8H8)2 (cerocene) and
the ytterbocene Cp*2Yb(bipy) is reported from magnetic susceptibility and
L_III-edge x-ray absorption spectroscopy. These well-defined systems provide a
new way to study the Kondo effect on the nanoscale, should generate insight
into the Anderson Lattice problem, and indicate the importance of this
often-ignored contribution to bonding in organometallics.Comment: 4 pages, 5 figures (eps
Comparison of bulk milk antibody and youngstock serology screens for determining herd status for Bovine Viral Diarrhoea Virus
BACKGROUND: This paper examines the use of Bulk Milk antibody (BM Ab), Youngstock (YS) serology (Check Tests) and Bulk Milk PCR (BM PCR) for determining the presence or absence of animals persistently infected (PI) with Bovine Viral Diarrhoea Virus (BVDV) within a herd. Data is presented from 26 herds where average herd sizes were 343 and 98 animals for dairy and beef units respectively. Seventeen herds had sufficient data to analyse using Receiver Operating Characteristic (ROC) and probability curves enabling calculation of the sensitivity and specificity of BM Ab and YS Check tests for determining the presence of PI animals within herds in this dataset. RESULTS: Using BM Ab to screen a herd for the presence of PI animals, achieved a herd level sensitivity and specificity of 80.00 % (44.39–97.48 %) and 85.71 % (42.13–99.64 %) respectively (95 % confidence intervals quoted). Sensitivity and specificity of YS Check Tests at a cut off of 3/10 Ab positive YS were 81.82 % (48.22–97.72 %) and 66.67 % (22.28–95.67 %) respectively (95 % confidence interval). These results were achieved by comparing the screening tests to whole herd PI searches that took place 1–19 months after the initial screen with a mean interval of 8 months. Removal of this delay by taking BM samples on the day of a whole herd test and simulating a YS Check Test from the herd test data produced improvements in the reliability of the Check Tests. BM Ab sensitivity and specificity remained unchanged. However, the Check Test sensitivity and specificity improved to 90.9 % (58.72–99.77 %) and 100 % (54.07–100 %) respectively (95 % confidence interval) at a cut of off 2.5/10 Ab positive animals. Our limited BM PCR results identified 5/23 dairy farms with a positive BM PCR result; two contained milking PIs, two had non-milking PIs and another had no PIs identified. CONCLUSIONS: Delaying a PI search following an initial herd screen decreased the diagnostic accuracy and relevance of our results. With careful interpretation, longitudinal surveillance using a combination of the techniques discussed can successfully determine farm status and therefore allow changes in BVDV status to be detected early, thus enabling prompt action in the event of a BVDV incursion
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