Fatigue of friction stir welded 2024-T351 aluminium alloy

Fatigue failure characteristics of friction stir welds in 13mm gauge 2024-T351 plate have been assessed. Failure occurred from either the weld region (nugget/flow arm) or from the material immediately surrounding the weld. Fatigue failure from the surrounding material was essentially conventional, initiating from large S-phase intermetallic particles and growing in a macroscopic mode I manner. Corresponding fatigue lives were seen to be comparable to parent plate and results previously reported for similar welds in thinner plate. Failure over the weld region was identified with discontinuities in the macroscopic flow pattern of the weld flow arm. Subsequent crack growth showed pronounced macroscopic crack deflection around the ‘onion ring’ structure of the weld nugget. The bands making up the onion rings were identified with variations in local hardness levels, consistent with a mechanical contribution to the crack deflection process

IASME: Information Security Management Evolution for SMEs

Most of the research in information risk and risk management has focused on the needs of larger organisations. In the area of standards accreditation, the ISO/IEC 27001 Information Risk Management standard has continued to grow in acceptance and popularity with such organisations, although not to a significant extent with SMEs. An interesting product recently developed for ENISA (European Nations Information Security Association) based on the Carnegie-Mellon maturity model and aimed at SMEs has not so far filled the gap. In this paper, a researcher and two practitioners from the UK discuss an innovative development in the UK for addressing the information assurance needs of smaller organisations. They also share their perceptions about the security of national information infrastructures, and concerns that SMEs do not get the priority that their position in the supply chain would suggest they should have. The authors also explore the development and roll out of IASME (Information Assurance for SMEs), which they have developed in the context of a tight market, where spare cash is in short supply, and many SMEs are still in survival mode. The question for the business is therefore not seen as “can we afford to spend on information security” but “can we afford not to spend…” As well as the effect on being able to do business at all of having an SMEs systems compromised, there are also matters of reputation, and the growing threat of fines as a result of not complying with laws and regulations. The paper concludes with achievements of real businesses using the IASME process to cost-effectively achieve information assurance levels appropriate for themselves

The choice among non-callable bonds and make whole, claw back and otherwise ordinary callable bonds

This paper seeks to explain determinates of the choice and the pricing of various types of callable and non-callable bonds. We find that the popularity of different types of callable and non-callable bonds is significantly related to the economic environment. In addition, the popularity of claw back bonds appear to be driven by agency considerations, make whole bonds by the debt overhang problem, ordinary callable bonds by the need by banks to deal with interest rate changes and non-callable bonds by the need to raise funds as cheaply as possible. All else equal, firms pay a higher offer spread for the flexibility to call a claw back bond early via a new share offering whereas issuers of make whole bonds are rewarded with a lower offer spread for restricting calls to circumstances that does not expropriate bondholder wealth

Properties of the mechanosensitive channel MscS pore revealed by tryptophan scanning mutagenesis

Funding This work was supported by a Wellcome Trust Programme grant [092552/A/10/Z awarded to I.R.B., S.M., J. H. Naismith (University of St Andrews, St Andrews, U.K.), and S. J. Conway (University of Oxford, Oxford, U.K.)] (T.R. and M.D.E.), by a BBSRC grant (A.R.) [BB/H017917/1 awarded to I.R.B., J. H. Naismith, and O. Schiemann (University of St Andrews)], by a Leverhulme Emeritus Fellowship (EM-2012-060\2), and by a CEMI grant to I.R.B. from the California Institute of Technology. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013 FP7/2007-2011) under Grant PITN-GA-2011-289384 (FP7-PEOPLE-2011-ITN NICHE) (H.G.) (awarded to S.M.).Peer reviewedPublisher PD

Nonlinear microwave response of MgB2

We calculate the intrinsic nonlinear microwave response of the two gap superconductor MgB2 in the clean and dirty limits. Due to the small value of the pi band gap, the nonlinear response at low temperatures is larger than for a single gap Bardeen-Cooper-Schrieffer (BCS) s-wave superconductor with a transition temperature of 40 K. Comparing this result with the intrinsic nonlinear d-wave response of YBa2Cu3O7 (YBCO) we find a comparable response at temperatures around 20 K. Due to its two gap nature, impurity scattering in MgB2 can be used to reduce the nonlinear response if the scattering rate in the pi band is made larger than the one in the sigma band.Comment: 4 pages, 4 figure

Lipid bilayer composition influences small multidrug transporters

Background: Membrane proteins are influenced by their surrounding lipids. We investigate the effect of bilayer composition on the membrane transport activity of two members of the small multidrug resistance family; the Escherichia coli transporter, EmrE and the Mycobacterium tuberculosis, TBsmr. In particular we address the influence of phosphatidylethanolamine and anionic lipids on the activity of these multidrug transporters. Phosphatidylethanolamine lipids are native to the membranes of both transporters and also alter the lateral pressure profile of a lipid bilayer. Lipid bilayer lateral pressures affect membrane protein insertion, folding and activity and have been shown to influence reconstitution, topology and activity of membrane transport proteins. Results: Both EmrE and TBsmr are found to exhibit a similar dependence on lipid composition, with phosphatidylethanolamine increasing methyl viologen transport. Anionic lipids also increase transport for both EmrE and TBsmr, with the proteins showing a preference for their most prevalent native anionic lipid headgroup; phosphatidylglycerol for EmrE and phosphatidylinositol for TBsmr. Conclusion: These findings show that the physical state of the membrane modifies drug transport and that substrate translocation is dependent on in vitro lipid composition. Multidrug transport activity seems to respond to alterations in the lateral forces exerted upon the transport proteins by the bilayer