The impact of exercise in improving executive function impairments among children and adolescents with ADHD, autism spectrum disorder, and fetal alcohol spectrum disorder: a systematic review and meta-analysis

Objective: he goal of this work was to perform a systematic review and meta-analysis evaluating and comparing exercise related improvements in various executive function (EF) domains among children and adolescents with attention-deficit hyperactivity disorder (ADHD), Autism Spectrum Disorders (ASD), and Fetal Alcohol Spectrum Disorders (FASD). Methods: A systematic literature research was conducted in PubMed, CENTRAL, and PsycInfo from October 1st, 2018 through January 30th, 2019 for original peer-reviewed articles investigating the relationship between exercise interventions and improvements in three domains of executive function (working memory, attention/set shifting, and response inhibition) among children and adolescents with ADHD, ASD, and FASD. Effect sizes (ES) were extracted and combined with random-effects meta-analytic methods. Covariates and moderators were then analyzed using meta-regression and subgroup analyses. Results: A total of 28 studies met inclusion criteria, containing information on 1,281 youth (N=1197 ADHD, N= 54 ASD, N=30 FASD). For ADHD, exercise interventions were associated with moderate improvements in attention/set-shifting (ES 0.38, 95% CI 0.01-0.75, k=14) and approached significance for working memory (ES 0.35, 95%CI -0.17-0.88, k=5) and response inhibition (ES 0.39, 95%CI -0.02-0.80, k=12). For ASD and FASD, exercise interventions were associated with large improvements in working memory (ES 1.36, 95%CI 1.08-1.64) and response inhibition (ES 0.78, 95%CI 0.21-1.35) and approached significance for attention/set-shifting (ES 0.69, 95% -0.28-1.66). There was evidence of substantial methodologic and substantive heterogeneity among studies. Sample size, mean age, study design, and the number or duration of intervention sessions did not significantly moderate the relationship between exercise and executive function. Conclusion: Exercise interventions among children and adolescents with neurodevelopmental disorders were associated with moderate improvements in executive function domains. Of note, studies of youth with ASD and FASD tended to report higher effect sizes compared to studies of youth with ADHD, albeit few existing studies. Exercise may be a potentially cost-effective and readily implementable intervention to improve executive function in these populations

Child and adolescent psychiatrists\u27 attitudes and practices prescribing second generation antipsychotics

Objective: The purpose of this study was to examine psychiatrists\u27 attitudes and practices in prescribing second-generation antipsychotics (SGA) to children and adolescents (referred to here as “children”) and identify factors associated with off-label SGA use. Methods: A survey was mailed to a national, randomly selected sample of 1600 child and adolescent psychiatrists identified by the American Medical Association. Multivariable logistic regression was used to identify factors, including psychiatrists\u27 characteristics, practice characteristics, and psychiatrists\u27 attitudes, that are associated with off-label SGA use (i.e., SGAs used in children with attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, or nonbipolar mood disorders). Results: The final sample included 340 psychiatrists. Overall, respondents reported higher use and appropriateness of SGAs for United States Food and Drug Administration (FDA)-approved disorders, symptoms of aggression, and older child age. More than one third (36%) of respondents reported some off-label SGA use. Significant predictors of off-label use were: Practicing at inpatient/residential facilities (odds ratio [OR]=4.2,p=0.001); white/non-Hispanic race/ethnicity (OR=0.3, p\u3c0.0001), agreeing that SGAs should be used for ADHD with aggression (OR=7.1, p\u3c0.0001); and agreeing that SGAs should be used for severe delinquent behaviors (OR=1.9, p=0.03). Conclusions: Psychiatrists\u27 attitudes about prescribing SGAs to children exhibiting aggressive symptoms were associated with off-label SGA use. Research is needed to understand the construct of aggression, potential interaction effects of aggression with diagnostic criteria, and their impact on SGA use

Editorial: Global Widening of the Inequitable Child Mental Health Care Chasm During COVID-19

The long-standing and inequitable chasm between clinical need and child and adolescent mental health care has likely widened during the COVID-19 pandemic, especially for children and adolescents in developing low- and middle-income countries (LMICs). Internationally, the risk for suicidal behaviors among young people rose, while timely access to care worsened.1 People in LMICs are envisioned to be precariously positioned within a perfect storm characterized by greater exposure to life-threatening COVID-19-related social determinants of health that also pose higher risk of new and recurrent mental disorders.2 In this issue of the Journal, the study by Wong et al.3 is the first international study to report a substantial rise in emergency department (ED) visits for any psychiatric disorder and self-harm among children and adolescents after the onset of the COVID-19 pandemic. Using a retrospective cohort study design, ED visits for any psychiatric disorder and self-harm were compared between March-April of 2019 (prepandemic), 2020 (early pandemic), and 2021 (later pandemic), with the most recent time interval corresponding to the "third wave of the pandemic worldwide." The total sample included 8,174 psychiatric ED visits to 62 emergency units in 25 countries, including developing countries with lower-middle, upper-middle, and high incomes as well as developed countries with upper-middle and high incomes. Of these, 3,865 psychiatric ED visits in 13 countries had data for all time intervals. Using the complete data, compared with March-April 2019, the rate of ED visits for any psychiatric disorder was lower in March-April 2020, consistent with the abrupt drop reported in the United States that broadly aligns with statewide school closures and shelter in place orders.4,5 However, when comparing early pandemic with later pandemic time intervals matched by months, the rates for any psychiatric and self-harm ED visits were twice as high. Despite the sharp drop following the onset of the pandemic, when compared with the prepandemic time interval, the overall rates of ED visits for any psychiatric diagnosis and self-harm during the later pandemic were 50% and 70% higher, respectively. Girls were also at greater risk for self-harm ED visits following the onset of the COVID-19 pandemic. Compared with the prepandemic time interval matched by months, girls had almost twice the odds of a self-harm ED visit in March-April 2021. The international rise in self-harm ED visits likely driven by the increases among girls is also consistent with prior US studies.4,5