374 research outputs found
Safety and Efficacy of Continuous Flush Systems for Arterial and Pulmonary Artery Catheters
journal articleBiomedical Informatic
Detection of Coronal Mass Ejections in V471 Tauri with the Hubble Space Telescope
V471 Tauri, an eclipsing system consisting of a hot DA white dwarf (WD) and a
dK2 companion in a 12.5-hour orbit, is the prototype of the pre-cataclysmic
binaries. The late-type component is magnetically active, due to its being
constrained to rotate synchronously with the short orbital period. During a
program of UV spectroscopy of V471 Tau, carried out with the Goddard High
Resolution Spectrograph (GHRS) onboard the Hubble Space Telescope, we
serendipitously detected two episodes in which transient absorptions in the Si
III 1206 A resonance line appeared suddenly, on a timescale of <2 min. The
observations were taken in a narrow spectral region around Ly-alpha, and were
all obtained near the two quadratures of the binary orbit, i.e., at maximum
projected separation (~3.3 Rsun) of the WD and K star.
We suggest that these transient features arise when coronal mass ejections
(CME's) from the K2 dwarf pass across the line of sight to the WD. Estimates of
the velocities, densities, and masses of the events in V471 Tau are generally
consistent with the properties of solar CME's. Given our detection of 2 events
during 6.8 hr of GHRS observing, along with a consideration of the restricted
range of latitudes and longitudes on the K star's surface that can give rise to
trajectories passing in front of the WD as seen from Earth, we estimate that
the active V471 Tau dK star emits some 100-500 CME's per day, as compared to
1-3 per day for the Sun. The K dwarf's mass-loss rate associated with CME's is
at least (5-25) x 10^{-14} Msun/yr, but it may well be orders of magnitude
higher if most of the silicon is in ionization states other than Si III.Comment: 24 pages AASTeX, 4 figures. Accepted by Astrophysical Journa
Environmental inactivation and irrigation-mediated regrowth of Escherichia coli O157:H7 on romaine lettuce when inoculated in a fecal slurry matrix
Field trials were conducted in July–August and October 2012 to quantify the inactivation rate of Escherichia coli O157:H7 when mixed with fecal slurry and applied to romaine lettuce leaves. Lettuce was grown under commercial conditions in Salinas Valley, California. One-half milliliter of rabbit, chicken, or pig fecal slurry, containing an average of 4.05 × 107 CFU E. coli O157:H7 (C0), was inoculated onto the upper (adaxial) surface of a lower leaf on 288 heads of lettuce per trial immediately following a 2.5 h irrigation event. To estimate the bacterial inactivation rate as a function of time, fecal matrix, irrigation and seasonal climate effects, sets of lettuce heads (n = 28) were sampled each day over 10 days and the concentration of E. coli O157:H7 (Ct) determined. E. coli O157:H7 was detected on 100% of heads during the 10-day duration, with concentrations ranging from ≤340 MPN/head (∼5-log reduction) to >3.45 × 1012 MPN/head (∼5-log growth). Relative to C0, on day 10 (Ct = 12) we observed an overall 2.6-log and 3.2-log mean reduction of E. coli O157:H7 in July and October, respectively. However, we observed relative maximum concentrations due to bacterial growth on day 6 (maximum Ct = 8) apparently stimulated by foliar irrigation on day 5. From this maximum there was a mean 5.3-log and 5.1-log reduction by day 10 (Ct = 12) for the July and October trials, respectively. This study provides insight into the inactivation and growth kinetics of E. coli O157:H7 on romaine lettuce leaves under natural field conditions. This study provides evidence that harvesting within 24 h post irrigation has the potential to increase the concentration of E. coli O157:H7 contamination, if present on heads of romaine lettuce; foliar irrigation can temporarily stimulate substantial regrowth of E. coli O157:H7
Frequent burning promotes invasions of alien plants into a mesic African savanna
Fire is both inevitable and necessary for maintaining the structure and functioning of mesic savannas. Without disturbances such as fire and herbivory, tree cover can increase at the expense of grass cover and over time dominate mesic savannas. Consequently, repeated burning is widely used to suppress tree recruitment and control bush encroachment. However, the effect of regular burning on invasion by alien plant species is little understood. Here, vegetation data from a long-term fire experiment, which began in 1953 in a mesic Zimbabwean savanna, were used to test whether the frequency of burning promoted alien plant invasion. The fire treatments consisted of late season fires, lit at 1-, 2-, 3-, and 4-year intervals, and these regularly burnt plots were compared with unburnt plots. Results show that over half a century of frequent burning promoted the invasion by alien plants relative to areas where fire was excluded. More alien plant species became established in plots that had a higher frequency of burning. The proportion of alien species in the species assemblage was highest in the annually burnt plots followed by plots burnt biennially. Alien plant invasion was lowest in plots protected from fire but did not differ significantly between plots burnt triennially and quadrennially. Further, the abundance of five alien forbs increased significantly as the interval (in years) between fires became shorter. On average, the density of these alien forbs in annually burnt plots was at least ten times as high as the density of unburnt plots. Plant diversity was also altered by long-term burning. Total plant species richness was significantly lower in the unburnt plots compared to regularly burnt plots. These findings suggest that frequent burning of mesic savannas enhances invasion by alien plants, with short intervals between fires favouring alien forbs. Therefore, reducing the frequency of burning may be a key to minimising the risk of alien plant spread into mesic savannas, which is important because invasive plants pose a threat to native biodiversity and may alter savanna functioning
The Atacama Cosmology Telescope: The LABOCA/ACT Survey of Clusters at All Redshifts
We present a multi-wavelength analysis of eleven Sunyaev Zel'dovich effect
(SZE)-selected galaxy clusters (ten with new data) from the Atacama Cosmology
Telescope (ACT) southern survey. We have obtained new imaging from the Large
APEX Bolometer Camera (345GHz; LABOCA) on the Atacama Pathfinder EXperiment
(APEX) telescope, the Australia Telescope Compact Array (2.1GHz; ATCA), and the
Spectral and Photometric Imaging Receiver (250, 350, and ;
SPIRE) on the Herschel Space Observatory. Spatially-resolved 345GHz SZE
increments with integrated S/N > 5 are found in six clusters. We compute 2.1GHz
number counts as a function of cluster-centric radius and find significant
enhancements in the counts of bright sources at projected radii . By extrapolating in frequency, we predict that the combined
signals from 2.1GHz-selected radio sources and 345GHz-selected SMGs contaminate
the 148GHz SZE decrement signal by ~5% and the 345GHz SZE increment by ~18%.
After removing radio source and SMG emission from the SZE signals, we use ACT,
LABOCA, and (in some cases) new Herschel SPIRE imaging to place constraints on
the clusters' peculiar velocities. The sample's average peculiar velocity
relative to the cosmic microwave background is .Comment: 19 pages, 11 figures, Accepted for Publication in The Astrophysical
Journa
Precision Epoch of Reionization studies with next-generation CMB experiments
Future arcminute resolution polarization data from ground-based Cosmic
Microwave Background (CMB) observations can be used to estimate the
contribution to the temperature power spectrum from the primary anisotropies
and to uncover the signature of reionization near in the small
angular-scale temperature measurements. Our projections are based on combining
expected small-scale E-mode polarization measurements from Advanced ACTPol in
the range with simulated temperature data from the full Planck
mission in the low and intermediate region, . We show that
the six basic cosmological parameters determined from this combination of data
will predict the underlying primordial temperature spectrum at high multipoles
to better than accuracy. Assuming an efficient cleaning from
multi-frequency channels of most foregrounds in the temperature data, we
investigate the sensitivity to the only residual secondary component, the
kinematic Sunyaev-Zel'dovich (kSZ) term. The CMB polarization is used to break
degeneracies between primordial and secondary terms present in temperature and,
in effect, to remove from the temperature data all but the residual kSZ term.
We estimate a detection of the diffuse homogeneous kSZ signal from
expected AdvACT temperature data at , leading to a measurement of
the amplitude of matter density fluctuations, , at precision.
Alternatively, by exploring the reionization signal encoded in the patchy kSZ
measurements, we bound the time and duration of the reionization with
and . We find that
these constraints degrade rapidly with large beam sizes, which highlights the
importance of arcminute-scale resolution for future CMB surveys.Comment: 10 pages, 10 figure
The Atacama Cosmology Telescope: Cross Correlation with Planck maps
We present the temperature power spectrum of the Cosmic Microwave Background
obtained by cross-correlating maps from the Atacama Cosmology Telescope (ACT)
at 148 and 218 GHz with maps from the Planck satellite at 143 and 217 GHz, in
two overlapping regions covering 592 square degrees. We find excellent
agreement between the two datasets at both frequencies, quantified using the
variance of the residuals between the ACT power spectra and the ACTxPlanck
cross-spectra. We use these cross-correlations to calibrate the ACT data at 148
and 218 GHz, to 0.7% and 2% precision respectively. We find no evidence for
anisotropy in the calibration parameter. We compare the Planck 353 GHz power
spectrum with the measured amplitudes of dust and cosmic infrared background
(CIB) of ACT data at 148 and 218 GHz. We also compare planet and point source
measurements from the two experiments.Comment: 9 pages, 8 figure
On the reliability of inflaton potential reconstruction
If primordial scalar and tensor perturbation spectra can be inferred from
observations of the cosmic background radiation and large-scale structure, then
one might hope to reconstruct a unique single-field inflaton potential capable
of generating the observed spectra. In this paper we examine conditions under
which such a potential can be reliably reconstructed. For it to be possible at
all, the spectra must be well fit by a Taylor series expansion. A complete
reconstruction requires a statistically-significant tensor mode to be measured
in the microwave background. We find that the observational uncertainties
dominate the theoretical error from use of the slow-roll approximation, and
conclude that the reconstruction procedure will never insidiously lead to an
irrelevant potential.Comment: 16 page LaTeX file with eight postscript figures embedded with epsf;
no special macros neede
The Atacama Cosmology Telescope: the stellar content of galaxy clusters selected using the Sunyaev-Zel'dovich effect
We present a first measurement of the stellar mass component of galaxy
clusters selected via the Sunyaev-Zel'dovich (SZ) effect, using 3.6 um and 4.5
um photometry from the Spitzer Space Telescope. Our sample consists of 14
clusters detected by the Atacama Cosmology Telescope (ACT), which span the
redshift range 0.27 < z < 1.07 (median z = 0.50), and have dynamical mass
measurements, accurate to about 30 per cent, with median M500 = 6.9 x 10^{14}
MSun. We measure the 3.6 um and 4.5 um galaxy luminosity functions, finding the
characteristic magnitude (m*) and faint-end slope (alpha) to be similar to
those for IR-selected cluster samples. We perform the first measurements of the
scaling of SZ-observables (Y500 and y0) with both brightest cluster galaxy
(BCG) stellar mass and total cluster stellar mass (M500star). We find a
significant correlation between BCG stellar mass and Y500 (E(z)^{-2/3} DA^2
Y500 ~ M*^{1.2 +/- 0.6}), although we are not able to obtain a strong
constraint on the slope of the relation due to the small sample size.
Additionally, we obtain E(z)^{-2/3} DA^2 Y500 ~ M500star^{1.0 +/- 0.6} for the
scaling with total stellar mass. The mass fraction in stars spans the range
0.006-0.034, with the second ranked cluster in terms of dynamical mass (ACT-CL
J0237-4939) having an unusually low total stellar mass and the lowest stellar
mass fraction. For the five clusters with gas mass measurements available in
the literature, we see no evidence for a shortfall of baryons relative to the
cosmic mean value.Comment: Accepted for publication in MNRAS; 12 pages, 10 figure
Paraneoplastic thrombocytosis in ovarian cancer
<p>Background: The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that
platelets play in abetting cancer growth are unclear.</p>
<p>Methods: We analyzed clinical data on 619 patients with epithelial ovarian cancer to test associations between platelet counts and disease outcome. Human samples and mouse
models of epithelial ovarian cancer were used to explore the underlying mechanisms
of paraneoplastic thrombocytosis. The effects of platelets on tumor growth and angiogenesis were ascertained.</p>
<p>Results: Thrombocytosis was significantly associated with advanced disease and shortened
survival. Plasma levels of thrombopoietin and interleukin-6 were significantly elevated
in patients who had thrombocytosis as compared with those who did not. In mouse
models, increased hepatic thrombopoietin synthesis in response to tumor-derived
interleukin-6 was an underlying mechanism of paraneoplastic thrombocytosis. Tumorderived interleukin-6 and hepatic thrombopoietin were also linked to thrombocytosis
in patients. Silencing thrombopoietin and interleukin-6 abrogated thrombocytosis in
tumor-bearing mice. Anti–interleukin-6 antibody treatment significantly reduced platelet counts in tumor-bearing mice and in patients with epithelial ovarian cancer. In
addition, neutralizing interleukin-6 significantly enhanced the therapeutic efficacy of
paclitaxel in mouse models of epithelial ovarian cancer. The use of an antiplatelet
antibody to halve platelet counts in tumor-bearing mice significantly reduced tumor
growth and angiogenesis.</p>
<p>Conclusions: These findings support the existence of a paracrine circuit wherein increased production of thrombopoietic cytokines in tumor and host tissue leads to paraneoplastic
thrombocytosis, which fuels tumor growth. We speculate that countering paraneoplastic thrombocytosis either directly or indirectly by targeting these cytokines may have
therapeutic potential. </p>
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