INFORMATIVITY AND EFFECTIVITY OF VERBAL CONTACT BETWEEN PHYSICIAN AND PATIENT

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DYNAMICS OF PSYCHOLOGICAL STATE OF PATIENTS WITH MYOCARDIAL INFARCTION DURING POSTCLINICAL REHABILITATION

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DIAGNOSTIC AND THERAPEUTIC DILEMMAS IN MALIGNANT LYMPHOMAS

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Facies transition and biostratigraphic correlation of the Upper Silurian and Lower Devonian in West Bulgaria

Upper Silurian and Lower Devonian shelf deposits in West Bulgaria are exposed in three main Alpine tectonic units: the West Balkan Unit, the Lyubash Monocline and the Morava Unit. The West Balkan and Lyubash units consist of siliciclastic deposits: black graptolitic shales, banded pale shales and black siltstones. The Ludlow, Pridoli, Lochkovian, Pragian and Emsian were recognized on the basis of graptolite and tentaculite faunas. In the Morava Unit, the Ludlow black shales are progressively replaced by clayey limestones and nodular and micritic limestones in the Pridoli and Early Devonian. Newly obtained conodonts show the presence of the siluricus, eosteinhornensis, woschmidti, postwoschmidti, delta-pesavis, sulcatus, dehiscens and gronbergi zones. Petrographic study of the Morava Unit shows an increasing carbonate content and shallowing conditions upwards. The biostratigraphical correlation and facies interpretation reveal the coeval existence of two different depositional environments within the same shelf basin as well as a gradual shift in proximal direction

Comparative Assessment of uNGAL, uNAG and Cystatin C As Early Biomarkers in Renal Post-Transplant Patients

Urinary neutrophil gelatinase-associated lipocalin (uNGAL), urinary N-acetyl-bd-glucosaminidase (NAG), urinary α1-microglobulin/creatinine ratio and cystatin C have been suggested as potential early markers of delayed graft function (DGF) following kidney transplantation. We conducted a prospective study in 50 consecutive kidney transplant recipients to evaluate serial changes of these biomarkers within the first week after transplantation and assess their performance in predicting DGF (dialysis requirement during initial post-transplant week) and graft function throughout the first year. Urine samples were collected on post-transplantation days 0, 1, 2, 4, and 7. Statistical analysis: Linear mixed and multivariable regression models, receiver-operating characteristic (ROC), and areas under ROC curves were used. At all-time points, mean urinary NGAL levels were significantly higher in patients developing DGF. Shortly after transplantation (3-6 h), uNGAL and uNAG values were higher in DGF recipients (on average +242 ng/mL; NAG – 6.8 U/mmol creatinine, considering mean dialysis time of 4.1 years) and rose further in the following days, contrasting with prompt function recipients. On Day-1 uNGAL levels accurately predicted DGF (AUC-ROC = 0.93), with a performance higher than serum creatinine (AUC-ROC = 0.76), and similar to cystatin C (AUC-ROC = 0.95). Multivariable analyses revealed that uNGAL levels at days 4 and 7 were strongly associated with one-year serum creatinine level. Urinary NGAL, serum cystatin C is an early marker of graft injury and is independently associated with dialysis requirement within one week after transplantation and one-year graft function

Activity of Bacillus thuringiensis D(delta)-endotoxins against codling moth (Cydia pomonella L.) larvae

Solubilized protoxins of nine Cry1 and one hybrid Cry1 ¿-endotoxin from Bacillus thuringiensis were tested for their activity against larvae of the codling moth (Cydia pomonella L). Cry1Da was the most toxic, followed by Cry1Ab, Cry1Ba, and Cry1Ac, while Cry1Aa, Cry1Fa, Cry1Ia, and SN19 were still less active. Cry1Ca and Cry1Cb showed no activity. In vitro trypsin activation increased activity of all eight active ¿-endotoxins, and dramatically enhanced toxicity of hybrid SN19, Cry1Aa, Cry1Ac, and Cry1Fa. The differences between toxicity of proteins before and after trypsin digestion suggests that proteolytic activation in the C. pomonella digestive tract plays a critical role for the activity of Cry proteins against this insect

New biostratigraphical data from the Ordovician of Bulgaria

7 páginas, 2 figuras.-- Edited by: G. L. Albanesi / M. S. Beresi / S. H. Peralta.-- Proceedings of the International Symposium on the Ordovician System. San Juan - Argentina 2003.Peer reviewe