Nonlinear elliptic equations involving the p-Laplacian with mixed Dirichlet-Neumann boundary conditions

In this paper, a nonlinear differential problem involving the p-Laplacian operator with mixed boundary conditions is investigated. In particular, the existence of three non-zero solutions is established by requiring suitable behavior on the nonlinearity. Concrete examples illustrate the abstract results

Improved Action Functionals in Non-Perturbative Quantum Gravity

Models of gravity with variable G and Lambda have acquired greater relevance after the recent evidence in favour of the Einstein theory being non-perturbatively renormalizable in the Weinberg sense. The present paper builds a modified Arnowitt-Deser-Misner (ADM) action functional for such models which leads to a power-law growth of the scale factor for pure gravity and for a massless phi**4 theory in a Universe with Robertson-Walker symmetry, in agreement with the recently developed fixed-point cosmology. Interestingly, the renormalization-group flow at the fixed point is found to be compatible with a Lagrangian description of the running quantities G and Lambda.Comment: Latex file. Record without file already exists on SLAC-SPIRES, and hence that record and the one for the present arxiv submission should become one record onl

Cosmological Perturbations in Renormalization Group Derived Cosmologies

A linear cosmological perturbation theory of an almost homogeneous and isotropic perfect fluid Universe with dynamically evolving Newton constant $G$ and cosmological constant $\Lambda$ is presented. A gauge-invariant formalism is developed by means of the covariant approach, and the acoustic propagation equations governing the evolution of the comoving fractional spatial gradients of the matter density, $G$, and $\Lambda$ are thus obtained. Explicit solutions are discussed in cosmologies where both $G$ and $\Lambda$ vary according to renormalization group equations in the vicinity of a fixed point.Comment: 22 pages, revtex, subeqn.sty, to appear on IJMP

Dynamical System Analysis of Cosmologies with Running Cosmological Constant from Quantum Einstein Gravity

We discuss a mechanism that induces a time-dependent vacuum energy on cosmological scales. It is based on the instability induced renormalization triggered by the low energy quantum fluctuations in a Universe with a positive cosmological constant. We employ the dynamical systems approach to study the qualitative behavior of Friedmann-Robertson-Walker cosmologies where the cosmological constant is dynamically evolving according with this nonperturbative scaling at low energies. It will be shown that it is possible to realize a "two regimes" dark energy phases, where an unstable early phase of power-law evolution of the scale factor is followed by an accelerated expansion era at late times.Comment: 26 pages, 4 figures. To appear in New Journal of Physic

The neutron star in Cassiopeia A: equation of state, superfluidity, and Joule heating

The thermomagnetic evolution of the young neutron star in Cassiopea A is studied by considering fast neutrino emission processes. In particular, we consider neutron star models obtained from the equation of state computed in the framework of the Brueckner-Bethe-Goldstone many-body theory and variational methods, and models obtained with the Akmal-Pandharipande-Ravenhall equation of state. It is shown that it is possible to explain a fast cooling regime as the one observed in the neutron star in Cassiopea A if the Joule heating produced by dissipation of the small-scale magnetic field in the crust is taken into account. We thus argue that it is difficult to put severe constraints on the superfluid gap if the Joule heating is considered.Comment: 4 pages, 2 figures, to appear on A&A Letter

Noise Induced Phenomena in the Dynamics of Two Competing Species

Noise through its interaction with the nonlinearity of the living systems can give rise to counter-intuitive phenomena. In this paper we shortly review noise induced effects in different ecosystems, in which two populations compete for the same resources. We also present new results on spatial patterns of two populations, while modeling real distributions of anchovies and sardines. The transient dynamics of these ecosystems are analyzed through generalized Lotka-Volterra equations in the presence of multiplicative noise, which models the interaction between the species and the environment. We find noise induced phenomena such as quasi-deterministic oscillations, stochastic resonance, noise delayed extinction, and noise induced pattern formation. In addition, our theoretical results are validated with experimental findings. Specifically the results, obtained by a coupled map lattice model, well reproduce the spatial distributions of anchovies and sardines, observed in a marine ecosystem. Moreover, the experimental dynamical behavior of two competing bacterial populations in a meat product and the probability distribution at long times of one of them are well reproduced by a stochastic microbial predictive model.Comment: 23 pages, 8 figures; to be published in Math. Model. Nat. Phenom. (2016

The role of Background Independence for Asymptotic Safety in Quantum Einstein Gravity

We discuss various basic conceptual issues related to coarse graining flows in quantum gravity. In particular the requirement of background independence is shown to lead to renormalization group (RG) flows which are significantly different from their analogs on a rigid background spacetime. The importance of these findings for the asymptotic safety approach to Quantum Einstein Gravity (QEG) is demonstrated in a simplified setting where only the conformal factor is quantized. We identify background independence as a (the ?) key prerequisite for the existence of a non-Gaussian RG fixed point and the renormalizability of QEG.Comment: 2 figures. Talk given by M.R. at the WE-Heraeus-Seminar "Quantum Gravity: Challenges and Perspectives", Bad Honnef, April 14-16, 2008; to appear in General Relativity and Gravitatio

Culture of human cell lines by a pathogen-inactivated human platelet lysate

Alternatives to the use of fetal bovine serum (FBS) have been investigated to ensure xeno-free growth condition. In this study we evaluated the efficacy of human platelet lysate (PL) as a substitute of FBS for the in vitro culture of some human cell lines. PL was obtained by pools of pathogen inactivated human donor platelet (PLT) concentrates. Human leukemia cell lines (KG-1, K562, JURKAT, HL-60) and epithelial tumor cell lines (HeLa and MCF-7) were cultured with either FBS or PL. Changes in cell proliferation, viability, morphology, surface markers and cell cycle were evaluated for each cell line. Functional characteristics were analysed by drug sensitivity test and cytotoxicity assay. Our results demonstrated that PL can support growth and expansion of all cell lines, although the cells cultured in presence of PL experienced a less massive proliferation compared to those grown with FBS. We found a comparable percentage of viable specific marker-expressing cells in both conditions, confirming lineage fidelity in all cultures. Functionality assays showed that cells in both FBS- and PL-supported cultures maintained their normal responsiveness to adriamycin and NK cell-mediated lysis. Our findings indicate that PL is a feasible serum substitute for supporting growth and propagation of haematopoietic and epithelial cell lines with many advantages from a perspective of process standardization, ethicality and product safety