Cross-sections of large-angle hadron production in proton-- and pion--nucleus interactions VIII: aluminium nuclei and beam momenta from {\pm}3 GeV/c to {\pm}15 GeV/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% {\lambda}int thick stationary aluminium target, of proton and pion beams with momentum from \pm3 GeV/c to \pm15 GeV/c. Results are given for secondary particles with production angles between 20 and 125 degrees. Cross-sections on aluminium nuclei are compared with cross-sections on beryllium, carbon, copper, tin, tantalum and lead nuclei.Comment: 71 pages, 16 figures, 47 table

Cross-Sections of Large-Angle Hadron Production in Proton- and Pion-Nucleus Interactions V: Lead Nuclei and Beam Momenta from +/-3 Gev/c to +/-15 Gev/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% nuclear interaction length thick stationary lead target, of proton and pion beams with momentum from +/-3 GeV/c to +/-15 GeV/c. Results are given for secondary particles with production angles 20 to 125 degrees. Cross-sections on lead nuclei are compared with cross-sections on beryllium, copper, and tantalum nuclei.Comment: 67 pages, 13 figures, 47 table

Cross-sections of large-angle hadron production in proton- and pion-nucleus interactions VI: carbon nuclei and beam momenta from \pm 3 GeV/c to \pm 15 GeV/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% nuclear interaction length thick stationary carbon target, of proton and pion beams with momentum from \pm 3 GeV/c to \pm 15 GeV/c. Results are given for secondary particles with production angles between 20 and 125 degrees. Cross-sections on carbon nuclei are compared with cross-sections on beryllium, copper, tantalum and lead nuclei.Comment: 67 pages, 13 figure

Formation of culture of healthy lifestyle of students in the health-education system

The students belong to the risk group, as a reaction to high emotional and mental stress, sposobina to new conditions of living and learning imposes a negative impact on all spheres of life. All this leads to the deterioration of students’ adaptation, resulting in serious medical and socio-psychological problemsСтуденты относятся к группе повышенного риска, так как реакция на высокую эмоциональную и умственную нагрузку, приспособление к новым условиям проживания и обучения накладывает негативное воздействие на все сферы жизни. Всё это приводит к ухудшению адаптации студентов, следствием чего являются серьёзные медицинские и социально-психологические проблем

VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION

We realized, the definition, of polymorphic variants of genes of folate cycle (C677T, A1298C, A66G) in children with, essential hypertension, having the burdened, and not burdened, hereditary anamnesis of thrombosis. Frequency of the incidence of low functional allele polymorphisms C677T and. A1298C didn't exceed, ubiquitous in the general population, and. in agreement with, those obtained, in other studies, with, an unfavorable genotype GG A66G gene was more frequent than in the population. In all groups of children studied, most often occurred in the carriage of any one of the polymorphic genes, but the combination, of two or even three adverse alleles also met with, relatively high, frequency. No statistically significant differences in the distribution, of genotypes between groups were found

Dermatoscopic diagnostics of nevus sebaceous of Jadassohn

Aim. The aim of this study was to examine the dermatoscopic signs of nevus sebaceous in its different age periods.Materials and methods. The study sample included 49 patients diagnosed with nevus sebaceus of Ja dassohn, seeking medical assistance in the Ryazan Region Clinical Dermatological and Venerealogical Dispensary during the 2014–2018 period. The age of the patients ranged from 1 month to 69 years.Results. The study describes the main dermatoscopic manifestations of nevus sebaceous of Jadassohn in its different age periods.Conclusions. The results of the study are significant for the differential diagnostics of nevus sebaceous of Jadassohn

Cross-Sections of Large-Angle Hadron Production in Proton- and Pion-Nucleus Interactions III: Tantalum Nuclei and Beam Momenta from +/-3 Gev/c to +/-15 Gev/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% nuclear interaction length thick stationary tantalum target, of proton and pion beams with momentum from +/-3 GeV/c to +/-15 GeV/c. Results are given for secondary particles with production angles between 20 and 125 degrees. They are of particular relevance for the optimization of the design parameters of the proton driver of a neutrino factory.Comment: 68 pages, 12 figures, corrections in v2: added 'HARP -CDP group' to author name, corrected two typos in Table 4 (last two p values for 65-90 degrees were all 0.972

Simcluster: clustering enumeration gene expression data on the simplex space

Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST "digital northern", are important high-throughput techniques for digital gene expression measurement. As other counting or voting processes, these measurements constitute compositional data exhibiting properties particular to the simplex space where the summation of the components is constrained. These properties are not present on regular Euclidean spaces, on which hybridization-based microarray data is often modeled. Therefore, pattern recognition methods commonly used for microarray data analysis may be non-informative for the data generated by transcript enumeration techniques since they ignore certain fundamental properties of this space.

Here we present a software tool, Simcluster, designed to perform clustering analysis for data on the simplex space. We present Simcluster as a stand-alone command-line C package and as a user-friendly on-line tool. Both versions are available at: http://xerad.systemsbiology.net/simcluster.

Simcluster is designed in accordance with a well-established mathematical framework for compositional data analysis, which provides principled procedures for dealing with the simplex space, and is thus applicable in a number of contexts, including enumeration-based gene expression data

Prevalence of sleep disorders in teenage girls in Irkutsk (questionnaire data)

Background. Adequate sleep ensures a person’s physical and psycho-emotional well-being. Adolescence is one of the critical stages of life. The exclusive attention of specialists and leveling the impact of adverse factors on the body during this period is the key to the proper development and preservation of the health of adolescents. Meanwhile, sleep problems in teenage girls remain poorly understood.The aim. To study the features of the sleep regime and quality of sleep of teenage girls in the city of Irkutsk.Materials and methods. A survey of 422 teenage girls in the city of Irkutsk was conducted using a translated version of a questionnaire about adolescent sleep habits to subjectively assess their sleep and wakefulness. Two groups were formed: group I – girls with sleep problems (n = 171); group II – girls without sleep problems (n = 251).Results. Sleep disorders among teenage girls in the city of Irkutsk occurred with a frequency of 40.52 %. In most cases, a complex effect of various unfavorable factors on the sleep process has been identified. The adolescents with sleep disorders we  examined were characterized by higher rates of sleep latency, later bedtime, earlier awakening, decreased time of night sleep, as well as changes in the sleep shift indicator towards its increase. These violations were noted both on weekdays and on weekends.Conclusions. Sleep problems were reported in 40.52% of respondents. The complex impact of various unfavorable factors on sleep quality has been revealed. The features of sleep hygiene of teenage girls are reflected. The group of girls with sleep problems was characterized by increased sleep latency, later bedtime, earlier awakening, reduced sleep time, and an increase in sleep shift

Obstructive sleep apnea and amyloid-β42 in adolescents: The results of a pilot study

Background. Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive collapse of the upper airway during sleep leading to intermittent hypoxia, excessive arousals and disrupt of sleep homeostasis. OSA is associated with obesity as well as pathological dynamics of cerebral beta-amyloid and dementia.The aim. Comparative assessment of the plasma beta-amyloid 42 levels in adolescents, depending on the presence or absence of OSA and obesity.Materials and methods. Seventy-four obese and non-obese male adolescents were included in the study. All participants underwent polysomnography to verify OSA and measure sleep parameters, and venipuncture for the assessment of betaamyloid 42 by enzyme-linked immunosorbent assay (ELISA).Results. After polysomnography all adolescents have been divided into four study groups: OSA obese (group 1; n = 28); non-OSA obese (group 2; n = 20); OSA non-obese (group 3; n = 11), and non-OSA non-obese (group 4 – control; n = 15). OSA obese adolescents had significant elevations in beta-amyloid 42 plasma levels compared with participants from three other groups (р = 0.007, p = 0.047 and p = 0.0002, correspondingly). Compared to both OSA non-obese adolescents and the control group, non-OSA obese patients had similar beta-amyloid 42 blood concentrations (p = 0.167 and p = 0.155, correspondingly). However, patients from the group 3 showed significantly higher beta-amyloid 42 plasma levels than controls (p = 0.004).Conclusions. Thus, OSA, accompanied by intermittent nocturnal hypoxia, and particularly OSA and obesity comorbidity, in adolescents is associated with increased beta-amyloid 42 circulating concentrations, which has a major role in pathogenesis of dementia. Beta-amyloid 42 plasma level may be recommended for use as early biomarker of cognitive impairment and neurodegenerative diseases, but future researches are needed