Search for the associated production of the Higgs boson with a top-quark pair

A search for the standard model Higgs boson produced in association with a top-quark pair t t ¯ H (tt¯H) is presented, using data samples corresponding to integrated luminosities of up to 5.1 fb −1 and 19.7 fb −1 collected in pp collisions at center-of-mass energies of 7 TeV and 8 TeV respectively. The search is based on the following signatures of the Higgs boson decay: H → hadrons, H → photons, and H → leptons. The results are characterized by an observed t t ¯ H tt¯H signal strength relative to the standard model cross section, μ = σ/σ SM ,under the assumption that the Higgs boson decays as expected in the standard model. The best fit value is μ = 2.8 ± 1.0 for a Higgs boson mass of 125.6 GeV

Measurement of prompt Jψ\psi pair production in pp collisions at \sqrt s = 7 Tev

Production of prompt J/ ψ meson pairs in proton-proton collisions at s s√ = 7 TeV is measured with the CMS experiment at the LHC in a data sample corresponding to an integrated luminosity of about 4.7 fb −1 . The two J/ ψ mesons are fully reconstructed via their decays into μ + μ − pairs. This observation provides for the first time access to the high-transverse-momentum region of J/ ψ pair production where model predictions are not yet established. The total and differential cross sections are measured in a phase space defined by the individual J/ ψ transverse momentum ( p T J/ ψ ) and rapidity (| y J/ ψ |): | y J/ ψ | 6.5 GeV/ c ; 1.2 4.5 GeV/ c . The total cross section, assuming unpolarized prompt J/ ψ pair production is 1.49 ± 0.07 (stat) ±0.13 (syst) nb. Different assumptions about the J/ ψ polarization imply modifications to the cross section ranging from −31% to +27%

Construction status and prospects of the Hyper-Kamiokande project

The Hyper-Kamiokande project is a 258-kton Water Cherenkov together with a 1.3-MW high-intensity neutrino beam from the Japan Proton Accelerator Research Complex (J-PARC). The inner detector with 186-kton fiducial volume is viewed by 20-inch photomultiplier tubes (PMTs) and multi-PMT modules, and thereby provides state-of-the-art of Cherenkov ring reconstruction with thresholds in the range of few MeVs. The project is expected to lead to precision neutrino oscillation studies, especially neutrino CP violation, nucleon decay searches, and low energy neutrino astronomy. In 2020, the project was officially approved and construction of the far detector was started at Kamioka. In 2021, the excavation of the access tunnel and initial mass production of the newly developed 20-inch PMTs was also started. In this paper, we present a basic overview of the project and the latest updates on the construction status of the project, which is expected to commence operation in 2027

Prospects for neutrino astrophysics with Hyper-Kamiokande

Hyper-Kamiokande is a multi-purpose next generation neutrino experiment. The detector is a two-layered cylindrical shape ultra-pure water tank, with its height of 64 m and diameter of 71 m. The inner detector will be surrounded by tens of thousands of twenty-inch photosensors and multi-PMT modules to detect water Cherenkov radiation due to the charged particles and provide our fiducial volume of 188 kt. This detection technique is established by Kamiokande and Super-Kamiokande. As the successor of these experiments, Hyper-K will be located deep underground, 600 m below Mt. Tochibora at Kamioka in Japan to reduce cosmic-ray backgrounds. Besides our physics program with accelerator neutrino, atmospheric neutrino and proton decay, neutrino astrophysics is an important research topic for Hyper-K. With its fruitful physics research programs, Hyper-K will play a critical role in the next neutrino physics frontier. It will also provide important information via astrophysical neutrino measurements, i.e., solar neutrino, supernova burst neutrinos and supernova relic neutrino. Here, we will discuss the physics potential of Hyper-K neutrino astrophysics

Search for standard model production of four top quarks in the lepton + jets channel in pp collisions at √s = 8 TeV

A search is presented for standard model (SM) production of four top quarks t t ¯ t t ¯ (tt¯tt¯) in pp collisions in the lepton + jets channel. The data correspond to an integrated luminosity of 19.6 fb −1 recorded at a centre-of-mass energy of 8 TeV with the CMS detector at the CERN LHC. The expected cross section for SM t t ¯ t t ¯ tt¯tt¯ production is σ t t ¯ t t ¯ S M ≈ 1 f b σSMtt¯tt¯≈1fb . A combination of kinematic reconstruction and multivariate techniques is used to distinguish between the small signal and large background. The data are consistent with expectations of the SM, and an upper limit of 32 fb is set at a 95% confidence level on the cross section for producing four top quarks in the SM, where a limit of 32 ± 17 fb is expected

Harnessing Polypharmacology with Medicinal Chemistry

Polypharmacology has expanded enormously over the last ten years, with several multitarget drugs (MTDs) already in the market. This Viewpoint provides a basis for a discussion about the critical need to develop MTDs in a more rationale and conscious way. A checklist to maximize success in polypharmacology is proposed

Does conjugation of quinones with polyamines and amino acids improve their anti-Trypanosoma/-Leishmania potential?

As a common chemical motif, quinones are recurrent among compounds showing useful antiparasitic properties. Numerous derivatives displayed potent activity against Trypanosoma and Leishmania. However, clinical research with these compounds has been hampered by safety concerns. Subsequent efforts to improve their therapeutic properties have been made by modifying the quinone framework. Another rational strategy to improve selectivity is to combine the moiety with a vector selectively recognized by the parasite. Previous studies suggest that polyamines and arginine might act as carriers, which transport cytotoxic agents into parasites exploiting specific permeases. To explore this possibility, naphthoquinones and anthraquinones developed in our laboratory have been conjugated to polyamines and basic amino acids, affording two novel libraries of hybrid compounds. These molecules may show a dual mechanism of action: preventing parasite growth i) by delivery of the toxic moiety and ii) by interference with the polyamine biosynthetic pathway

Multitargeted drugs for the treatment of Alzheimer's disease

In this book chapter, we first introduce the concept of multitargeted drugs in neurodegenerative diseases. Then, we report and discuss some examples of multitargeted drug candidates in (pre)clinical trials for the treatment of Alzheimer's disease

A Different Kind of Medicinal Chemistry Toolbox

To attract and retain women in medicinal chemistry, a toolbox of resources and opportunities is suggested. Scientific meetings, books, affinity groups, training courses, and networks all can provide support and strategies to help increase the percentage of women in the field