779 research outputs found
General Relativity as Classical Limit of Evolutionary Quantum Gravity
We analyze the dynamics of the gravitational field when the covariance is
restricted to a synchronous gauge. In the spirit of the Noether theorem, we
determine the conservation law associated to the Lagrangian invariance and we
outline that a non-vanishing behavior of the Hamiltonian comes out. We then
interpret such resulting non-zero ``energy'' of the gravitational field in
terms of a dust fluid. This new matter contribution is co-moving to the slicing
and it accounts for the ``materialization'' of a synchronous reference from the
corresponding gauge condition. Further, we analyze the quantum dynamics of a
generic inhomogeneous Universe as described by this evolutionary scheme,
asymptotically to the singularity. We show how the phenomenology of such a
model overlaps the corresponding Wheeler-DeWitt picture. Finally, we study the
possibility of a Schr\"odinger dynamics of the gravitational field as a
consequence of the correspondence inferred between the ensemble dynamics of
stochastic systems and the WKB limit of their quantum evolution. We demonstrate
that the time dependence of the ensemble distribution is associated with the
first order correction in to the WKB expansion of the energy spectrum.Comment: 23 pages, to appear on Class. Quant. Gra
On the Existence of the Logarithmic Correction Term in Black Hole Entropy-Area Relation
In this paper we consider a model universe with large extra dimensions to
obtain a modified black hole entropy-area relation. We use the generalized
uncertainty principle to find a relation between the number of spacetime
dimensions and the presence or vanishing of logarithmic prefactor in the black
hole entropy-area relation. Our calculations are restricted to the
microcanonical ensembles and we show that in the modified entropy-area
relation, the microcanonical logarithmic prefactor appears only when spacetime
has an even number of dimensions.Comment: 9 Pages, No Figure
Expansion-induced contribution to the precession of binary orbits
We point out the existence of new effects of global spacetime expansion on
local binary systems. In addition to a possible change of orbital size, there
is a contribution to the precession of elliptic orbits, to be added to the
well-known general relativistic effect in static spacetimes, and the
eccentricity can change. Our model calculations are done using geodesics in a
McVittie metric, representing a localized system in an asymptotically
Robertson-Walker spacetime; we give a few numerical estimates for that case,
and indicate ways in which the model should be improved.Comment: revtex, 7 pages, no figures; revised for publication in Classical and
Quantum Gravity, with minor changes in response to referees' comment
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells
BACKGROUND: Bruton's tyrosine kinase (Btk) is essential for B cell development and function. Mutations of Btk elicit X-linked agammaglobulinemia in humans and X-linked immunodeficiency in the mouse. Btk has been proposed to participate in B cell antigen receptor-induced signaling events leading to activation of phospholipase C-Îł2 (PLCÎł2) and calcium mobilization. However it is unclear whether Btk activation is alone sufficient for these signaling events, and whether Btk can activate additional pathways that do not involve PLCÎł2. To address such issues we have generated Btk:ER, a conditionally active form of the kinase, and expressed it in the PLCÎł2-deficient DT40 B cell line. RESULTS: Activation of Btk:ER was sufficient to induce multiple B cell signaling pathways in PLCÎł2-sufficient DT40 cells. These included tyrosine phosphorylation of PLCÎł2, mobilization of intracellular calcium, activation of extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways, and apoptosis. In DT40 B cells deficient for PLCÎł2, Btk:ER activation failed to induce the signaling events described above with the consequence that the cells failed to undergo apoptosis. CONCLUSIONS: These data suggest that Btk:ER regulates downstream signaling pathways primarily via PLCÎł2 in B cells. While it is not known whether activated Btk:ER precisely mimics activated Btk, this conditional system will likely facilitate the dissection of the role of Btk and its family members in a variety of biological processes in many different cell types
Hawking Temperature in Taub-NUT (A)dS spaces via the Generalized Uncertainty Principle
Using the extended forms of the Heisenberg uncertainty principle from string
theory and the quantum gravity theory, we drived Hawking temperature of a
Taub-Nut-(A)dS black hole. In spite of their distinctive natures such as
asymptotically locally flat and breakdown of the area theorem of the horizon
for the black holes, we show that the corrections to Hawking temperature by the
generalized versions of the the Heisenberg uncertainty principle increases like
the Schwarzschild-(A)dS black hole and give the reason why the Taub-Nut-(A)dS
metric may have AdS/CFT dual picture.Comment: version published in General Relativity and Gravitatio
Semiclassical States in Quantum Cosmology: Bianchi I Coherent States
We study coherent states for Bianchi type I cosmological models, as examples
of semiclassical states for time-reparametrization invariant systems. This
simple model allows us to study explicitly the relationship between exact
semiclassical states in the kinematical Hilbert space and corresponding ones in
the physical Hilbert space, which we construct here using the group averaging
technique. We find that it is possible to construct good semiclassical physical
states by such a procedure in this model; we also discuss the sense in which
the original kinematical states may be a good approximation to the physical
ones, and the situations in which this is the case. In addition, these models
can be deparametrized in a natural way, and we study the effect of time
evolution on an "intrinsic" coherent state in the reduced phase space, in order
to estimate the time for this state to spread significantly.Comment: 21 pages, 1 figure; Version to be published in CQG; The discussion
has been slightly reorganized, two references added, and some typos correcte
String-inspired cosmology: Late time transition from scaling matter era to dark energy universe caused by a Gauss-Bonnet coupling
The Gauss-Bonnet (GB) curvature invariant coupled to a scalar field
can lead to an exit from a scaling matter-dominated epoch to a late-time
accelerated expansion, which is attractive to alleviate the coincident problem
of dark energy. We derive the condition for the existence of cosmological
scaling solutions in the presence of the GB coupling for a general scalar-field
Lagrangian density , where is a kinematic
term of the scalar field. The GB coupling and the Lagrangian density are
restricted to be in the form and , respectively, where is a constant and is an
arbitrary function. We also derive fixed points for such a scaling Lagrangian
with a GB coupling and clarify the conditions
under which the scaling matter era is followed by a de-Sitter solution which
can appear in the presence of the GB coupling. Among scaling models proposed in
the current literature, we find that the models which allow such a cosmological
evolution are an ordinary scalar field with an exponential potential and a
tachyon field with an inverse square potential, although the latter requires a
coupling between dark energy and dark matter.Comment: 18 pages, 4 figures, version to appear in JCA
Integration of cell of origin into the clinical CNS International Prognostic Index improves CNS relapse prediction in DLBCL
Central nervous system (CNS) relapse carries a poor prognosis in diffuse large B-cell lymphoma (DLBCL). Integrating biomarkers into the CNS-International Prognostic Index (CNS-IPI) risk model may improve identification of patients at high risk for developing secondary CNS disease. CNS relapse was analyzed in 1418 DLBCL patients treated with obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone chemotherapy in the phase 3 GOYA study. Cell of origin (COO) was assessed using gene-expression profiling. BCL2 and MYC protein expression was analyzed by immunohistochemistry. The impact of CNS-IPI, COO, and BCL2/MYC dual-expression status on CNS relapse was assessed using a multivariate Cox regression model (data available in n = 1418, n = 933, and n = 688, respectively). High CNS-IPI score (hazard ratio [HR], 4.0; 95% confidence interval [CI], 1.3-12.3; P = .02) and activated B-cell\u2012like (ABC) (HR, 5.2; 95% CI, 2.1-12.9; P = .0004) or unclassified COO subtypes (HR, 4.2; 95% CI, 1.5-11.7; P = .006) were independently associated with CNS relapse. BCL2/MYC dual-expression status did not impact CNS relapse risk. Three risk subgroups were identified based on the presence of high CNS-IPI score and/or ABC/unclassified COO (CNS-IPI-C model): low risk (no risk factors, n = 450 [48.2%]), intermediate risk (1 factor, n = 408 [43.7%]), and high risk (both factors, n = 75 [8.0%]). Two-year CNS relapse rates were 0.5%, 4.4%, and 15.2% in the respective risk subgroups. Combining high CNS-IPI and ABC/unclassified COO improved CNS relapse prediction and identified a patient subgroup at high risk for developing CNS relapse. The study was registered at www.clinicaltrials.gov as #NCT01287741
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