Granisetron Effectiveness on Postoperative Nausea and Vomiting and the Need for Rescue Antiemetics

An estimated 20-30% of all surgery patients experience postoperative nausea and vomiting. These percentages could affect more than one million patients every year. The purpose of this study was to look at the effectiveness of low dose granisetron, a common antiemetic used for postoperative nausea and vomiting (PONV). This chart review looked at patients between the ages of 18-70 that had undergone open cholecystectomy and abdominal hysterectomy surgeries at a midwestem rural hospital. This study evaluated those patients that received granisetron and the need for additional antiemetics in the first 24 hours after surgery. This was a retrospective chart review using a convenience sample of 200 patients utilizing a data collection tool designed by the researcher. The study is a descriptive analysis of the use of granisetron for PONY. Data collection was analyzed using Statistical Package for Social Sciences (SPSS) method. The researcher found that a statistically significant number of patients that received low dose granisetron required rescue antiemetics within the first 24 hours after surgery. Of the 200 charts reviewed 179 met study criteria and of these 131 received low dose granisetron during surgery. Of the 131 patients that received granisetron 86 or 65.6% (p = \u3c.000) needed rescue antiemetics. Thus, in this patient population low dose granisetron was not effective in decreasing PONV. If PONV is reduced, there will be an increase in patient satisfaction, safety, and a decrease in health care costs. This facility’s current protocol for low dose granisetron is not a cost effective intraoperative antiemetic as evidenced by the need for rescue antiemetics in the first 24 hours post-op. This study did not show a correlation between the use of morphine for post-op pain control and the increased need for rescue antiemetics. The information from this study is beneficial to anesthesia providers in helping prevent and treat postoperative nausea and vomiting and to nursing professionals in helping improve patient outcome and satisfaction following open cholecystectomy and abdominal hysterectomy surgery

Alien Registration- Bolduc, Marie Josephine A. (Lewiston, Androscoggin County)

https://digitalmaine.com/alien_docs/30517/thumbnail.jp

Sea Level at Port Leopold, N.W.T. in 1848

Forty-seven days of hourly sea level and atmospheric pressure data collected in 1848 at Port Leopold, N.W.T., are analyzed using modern time series computation techniques. Tidal analysis reveals a mixed tide but mainly semi-diurnal. A detailed analysis of the tidal data reveals that the time-keeping of the record was as good as today's standard. A high correlation between hourly sea level and atmospheric pressure data demonstrates the inverse barometric effect.Key words: Arctic, sea level, tide, ice cover, free oscillation, lowpass, scatter diagram, time series, Resolute, Port LeopoldMots clés: Arctique, Niveau de la mer, marée, couvert de glace, oscillation libre, goulet, diagramme de dispersion, series chronologiques, Resolute, Port Léopol

Beyond the Rhetoric: Foundation Strategy

How do foundations maximize their impact? What is the role of strategy? Is your foundation strategic? Are you? This groundbreaking research examines the current state of decision making at large, private, U.S. foundations. Through in-depth interviews with CEOs and program officers, the study examines foundation leaders' view and use of strategy in making decisions. Analysis of their responses reveals four categories of decision makers ranging from nonstrategic to strategic. Beyond the Rhetoric sets the stage for future CEP research on the role of strategy in creating foundation impact, and highlights practical implications for CEOs, trustees, and program staff

Anticancer properties of chitosan on human melanoma are cell line dependent

Purpose: Chitosan, a natural macromolecule, is widely used in medical and pharmaceutical fields because of its distinctive properties such as bactericide, fungicide and above all its antitumor effects. Although its antitumor activity against different types of cancer had been previously described, its mechanism of action was not fully understood. Materials and methods: Coating of chitosan has been used in cell cultures with A375, SKMEL28, and RPMI7951 cell lines. Adherence, proliferation and apoptosis were investigated. Results: Our results revealed that whereas chitosan decreased adhesion of primary melanoma A375 cell line and decreased proliferation of primary melanoma SKMEL28 cell line, it had potent pro-apoptotic effects against RPMI7951, a metastatic melanoma cell line. In these latter cells, inhibition of specific caspases confirmed that apoptosis was effected through the mitochondrial pathway and Western blot analyses showed that chitosan induced an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL. More interestingly, chitosan exposure induced an exposition of a greater number of CD95 receptor at RPMI7951 surface, making them more susceptible to FasL-induced apoptosis. Conclusion: Our results indicate that chitosan could be a promising agent for further evaluations in antitumor treatments targeting melanoma

An assay for social interaction in Drosophila fragile X mutants

We developed a novel assay to examine social interactions in Drosophila and, as a first attempt, apply it here at examining the behavior of Drosophila Fragile X Mental Retardation gene (dfmr1) mutants. Fragile X syndrome is the most common cause of single gene intellectual disability (ID) and is frequently associated with autism. Our results suggest that dfmr1 mutants are less active than wild-type flies and interact with each other less often. In addition, mutants for one allele of dfmr1, dfmr1B55, are more likely to come in close contact with a wild-type fly than another dfmr1B55 mutant. Our results raise the possibility of defective social expression with preserved receptive abilities. We further suggest that the assay may be applied in a general strategy of examining endophenoypes of complex human neurological disorders in Drosophila, and specifically in order to understand the genetic basis of social interaction defects linked with ID

Present day challenges in understanding the geomagnetic hazard to national power grids

Power grids and pipeline networks at all latitudes are known to be at risk from the natural hazard of geomagnetically induced currents. At a recent workshop in South Africa, UK and South African scientists and engineers discussed the current understanding of this hazard, as it affects major power systems in Europe and Africa. They also summarised, to better inform the public and industry, what can be said with some certainty about the hazard and what research is yet required to develop useful tools for geomagnetic hazard mitigation

Developing a cluster-based approach for deciphering complexity in individuals with neurodevelopmental differences

ObjectiveIndividuals with neurodevelopmental disorders such as global developmental delay (GDD) present both genotypic and phenotypic heterogeneity. This diversity has hampered developing of targeted interventions given the relative rarity of each individual genetic etiology. Novel approaches to clinical trials where distinct, but related diseases can be treated by a common drug, known as basket trials, which have shown benefits in oncology but have yet to be used in GDD. Nonetheless, it remains unclear how individuals with GDD could be clustered. Here, we assess two different approaches: agglomerative and divisive clustering.MethodsUsing the largest cohort of individuals with GDD, which is the Deciphering Developmental Disorders (DDD), characterized using a systematic approach, we extracted genotypic and phenotypic information from 6,588 individuals with GDD. We then used a k-means clustering (divisive) and hierarchical agglomerative clustering (HAC) to identify subgroups of individuals. Next, we extracted gene network and molecular function information with regard to the clusters identified by each approach.ResultsHAC based on phenotypes identified in individuals with GDD revealed 16 clusters, each presenting with one dominant phenotype displayed by most individuals in the cluster, along with other minor phenotypes. Among the most common phenotypes reported were delayed speech, absent speech, and seizure. Interestingly, each phenotypic cluster molecularly included several (3–12) gene sub-networks of more closely related genes with diverse molecular function. k-means clustering also segregated individuals harboring those phenotypes, but the genetic pathways identified were different from the ones identified from HAC.ConclusionOur study illustrates how divisive (k-means) and agglomerative clustering can be used in order to group individuals with GDD for future basket trials. Moreover, the result of our analysis suggests that phenotypic clusters should be subdivided into molecular sub-networks for an increased likelihood of successful treatment. Finally, a combination of both agglomerative and divisive clustering may be required for developing of a comprehensive treatment