3 research outputs found
Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients
Objective
The inflammatory process is a very important stage in the development and prognosis of acute ischemic stroke (AIS). The monocyte to high-density lipoprotein (HDL) ratio (MHR) is accepted as a novel marker for demonstrating inflammation. However, the role of MHR as a predictor of mortality in patients with AIS remains unclear.
Methods
We retrospectively enrolled 466 patients who were referred to our clinic within the first 24hours of symptom presentation and who were diagnosed with AIS between January 2008 and June 2016. Four hundred and eight controls of similar age and gender were also included. The patient group was classified into two groups according to 30-day mortality. The groups were compared in terms of monocyte counts, HDL, and MHR values.
Results
The patient group had significantly higher monocyte counts and lower HDL levels; therefore, this group had higher values of MHR compared to controls. Additionally, the monocyte count and MHR value were higher, and the HDL level was lower in non-surviving patients (p<0.001). The MHR value was also observed as a significant independent variable of 30-day mortality in patients with AIS (p<0.001). The optimum cut-off value of MHR in predicting the 30-day mortality for patients with AIS was 17.52 (95% CI 0.95–0.98).
Conclusion
Our study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS
Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population
Background and Objectives: Genetic predisposition is an important risk
factor for coronary artery disease (CAD). In this study, we aimed to
evaluate the impact of rs10757274 and rs2383206 polymorphisms in
chromosome 9p21 on presence and severity of CAD in a Turkish population.
Subjects and Methods: A total of 646 patients who underwent coronary
angiography were included in this study. Coronary vessel score and
Gensini score were calculated to assess the angiographic severity of
CAD. Alleles of AA, AG, and GG were determined for rs10757274
(polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in
chromosome 9p21 from the blood samples.
Results: There was a significant difference between the alleles in
polymorphism-1 in the presence of coronary artery disease (38.9\% in AA,
48.0\% in GG and 56.4\% in AG, p=0.017). However, there was no
difference between the alleles in polymorphism-2. According to vessel
scores, there was a significant difference between the alleles in
polymorphism-1 (AA 0.71 +/- 1.04, GG 0.88 +/- 1.07, AG 1.06 +/- 1.12,
p=0.018). In polymorphism-2, vessel scores did not show a difference
between the alleles. In polymorphism-1, there was a significant
difference in Gensini score (p=0.041). Gensini scores did not differ
between the alleles in polymorphism-2 (p>0.05 for all). In multivariate
analyses, none of the alleles was an independent factor for presence of
CAD.
Conclusion: The presence of rs10757274 polymorphism including AG allele
in chromosome 9p21 was related to CAD. However, this relationship was
not independent of other cardiovascular risk factors