An expert statment on clinical considerations before treating NTM lung infection

International audienc

Lower respiratory tract involvement in recurrent respiratory papillomatosis in a multicentric cohort study

International audienceRecurrent respiratory papillomatosis (RRP) is a rare disease due to chronic Human Papillomavirus infection, occurring in childhood (JoRRP) or adults (AoRRP). PRR characterized by progressive obstruction papillomas mostly affecting upper airway and more rarely lower tract (LRT), including lungs. This study describes the characteristics of Jo AoRRP LRT at adulthood. French Quebecers’ national retrospective clinical, histological, therapeutic prognostic with RRP-LRT. Among 67 patients (pts), 17 (25%) were JoRRP 50 (75%) AoRRP. The mean age diagnosis was 5 yrs for 54 ENT involvement observed all 23 (46%) Lung 11 (76%) 2 (4%) Mean latency duration between lung 26 4 CT-scan findings cysts pts (74%) nodules/mass (13%), predominating lobes. 13 (19%) had malignant transformation squamous cell carcinoma trachea (n=3) (n=10). Associated factors female gender, JoRRP, HPV-11, repeated desobstruction tracheostomy while they HPV-16 presence involvements transformation. Overall mortality 9%, form, being (pandl