Scaffold searching: automated identification of similar ring systems for the design of combinatorial libraries

Rigid ring systems can be used to position receptor-binding functional groups in 3D space and they thus play an increasingly important role in the design of combinatorial libraries. This paper discusses the use of shape-similarity methods to identify ring systems that are structurally similar to, and aligned with, a user-defined target ring system. These systems can be used as alternative scaffolds for the construction of a combinatorial library

Measurement of the Effect on Single Bunch Stability of Changing Transition Energy in the CERN SPS

The SPS is the final accelerator in the chain which will be used to fill the Large Hadron Collider (LHC), at present under construction at CERN. The most critical limitation for single bunch intensity in the SPS comes from the longitudinal microwave instability. One of the ways to raise the instability threshold is to decrease the transition energy which can be obtained by perturbing the dispersion function. In order to test expectations an experiment was performed in the SPS using the existing lattice. By adjusting the betatron tune at 26 GeV to be close to a multiple of the machine super perio d, a situation not acceptable for regular operation, the transition energy was reduced from 22 to 19 GeV. The results of this change on the beam were measured directly from the bunch spectrum

Proton acceleration by irradiation of isolated spheres with an intense laser pulse

We report on experiments irradiating isolated plastic spheres with a peak laser intensity of 2-3 x 10(20) W cm(-2). With a laser focal spot size of 10 mu m full width half maximum (FWHM) the sphere diameter was varied between 520 nm and 19.3 mu m. Maximum proton energies of similar to 25 MeV are achieved for targets matching the focal spot size of 10 mu m in diameter or being slightly smaller. For smaller spheres the kinetic energy distributions of protons become nonmonotonic, indicating a change in the accelerating mechanism from ambipolar expansion towards a regime dominated by effects caused by Coulomb repulsion of ions. The energy conversion efficiency from laser energy to proton kinetic energy is optimized when the target diameter matches the laser focal spot size with efficiencies reaching the percent level. The change of proton acceleration efficiency with target size can be attributed to the reduced cross-sectional overlap of subfocus targets with the laser. Reported experimental observations are in line with 3D3V particle in cell simulations. They make use of well-defined targets and point out pathways for future applications and experiments.DFG via the Cluster of Excellence Munich-Centre for Advanced Photonics (MAP) Transregio SFB TR18NNSA DE-NA0002008Super-MUC pr48meIvo CermakCGC Instruments in design and realization of the Paul trap systemIMPRS-APSLMUexcellent Junior Research FundDAAD|ToIFEEuropean Union's Horizon research and innovation programme 633053Physic

Progress with the Upgrade of the SPS for the HL-LHC Era

The demanding beam performance requirements of the High Luminosity (HL-) LHC project translate into a set of requirements and upgrade paths for the LHC injector complex. In this paper the performance requirements for the SPS and the known limitations are reviewed in the light of the 2012 operational experience. The various SPS upgrades in progress and still under consideration are described, in addition to the machine studies and simulations performed in 2012. The expected machine performance reach is estimated on the basis of the present knowledge, and the remaining decisions that still need to be made concerning upgrade options are detailed.Comment: 3 p. Presented at 4th International Particle Accelerator Conference (IPAC 2013

CERN SPS Impedance in 2007

Each year several measurements of the beam coupling impedance are performed in both longitudinal and transverse planes of the CERN Super Proton Synchrotron to keep track of its evolution. In parallel, after the extensive and successful campaign of identification, classification and cure of the possible sources of (mainly longitudinal) impedance between 1998 and 2001, a new campaign (essentially for the transverse impedance this time) has started few years ago, in view of the operation of the SPS with higher intensity for the LHC luminosity upgrade. The present paper summarizes the results obtained from the measurements performed over the last few years and compares them to our predictions. In particular, it reveals that the longitudinal impedance is reasonably well understood and the main contributors have already been identified. However, the situation is quite different in the transverse plane: albeit the relative evolution of the transverse impedance over the last few years can be well explained by the introduction of the nine MKE kickers necessary for beam extraction towards the LHC, significant contributors to the SPS transverse impedance have not been identified yet

SPS Impedance

For many years several measurements of the beam coupling impedance have been performed each year in both longitudinal and transverse planes of the CERN Super Proton Synchrotron to keep track of the evolution of its hardware. Copious types of equipments had to be modified or added in the past to allow the SPS to produce the nominal LHC beam. The next challenge would be the operation of the SPS with higher intensity for the LHC luminosity upgrade, which requires a good knowledge of the machine impedance and in particular of its major contributors. The current understanding of the measurements performed over the last few years is presented in this paper. In particular, this analysis reveals that the longitudinal impedance is reasonably well understood, while the situation is less satisfactory in the transverse planes, where about half of the measured impedance still needs to be identified

Transverse Impedance of LHC Collimators

The transverse impedance in the LHC is expected to be dominated by the numerous collimators, most of which are made of Fibre-Reinforced-Carbon to withstand the impacts of high intensity proton beams in case of failures, and which will be moved very close to the beam, with full gaps of few millimetres, in order to protect surrounding super-conducting equipments. We present an estimate of the transverse resistive-wall impedance of the LHC collimators, the total impedance in the LHC at injection and top energy, the induced coupled-bunch growth rates and tune shifts, and finally the result of the comparison of the theoretical predictions with measurements performed in 2004 and 2006 on a prototype collimator installed in the SPS

LEP1 operation, 1989-1995

In October 1995, the last run foreseen for dedicated Z production at CERN was performed in LEP, thereby bringing to a close the first phase of operation of the machine. A total luminosity of 200 pb-1 has been delivered to each of the four experiments, which together have recorded the decays of over 20 millions Zs. Machine performance has increased to the extent that a good weekend in 1995 saw as much luminosity delivered as in the whole of 1989. This improvement has been made possible by a combination of several things. Over and above general operational expertise, special care went into the treatment and stabilisation of the closed orbit in order to obtain reproducible high performances with vertical beam-beam tune shifts exceeding values of xy = 0.04. Both Pretzel and Bunch Train schemes have been introduced to double the number of bunches, and high-tune optics have been developed to produce low transverse emittances which allow operation at the beam-beam limit throughout physics runs. Included in the integrated luminosity are data taken off the peak of the Z resonance, to allow precise determination of the mass and width of this particle. Accurate measurements of the beam energy during these runs have brought to the fore some unusual effects

Energy loss of proton and lead beams in the CERN-SPS

The energy loss of an unbunched beam circulating in the CERN-SPS has been obtained from the observed frequency change of a longitudinal Schottky signal. This experiment was carried out for protons at 14, 120 and 270 GeV/c and for lead ions PB82208 at Z .270 GeV/c momentum. The dominant effects which determine the energy loss are synchrotron radiation, ionization of the residual gas and parasitic mode loss in the resistive longitudinal impedance. Since all the protons in a lead nucleus radiate coherently the synchrotron radiation is proportional to Z2 like the other effects. The experimental results are analyzed and the contributions of the individual effects determined. Using an impedance of | Z/n | ~ 12 W gives the best fit through the experimental data