Solutions to axion electrodynamics in various geometries

Recently there has been a surge of new experimental proposals to search for ultralight axion dark matter with axion mass, m_{a}≲1  μeV. Many of these proposals search for small oscillating magnetic fields induced in or around a large static magnetic field. Lately, there has been interest in alternate detection schemes which search for oscillating electric fields in a similar setup. In this paper, we explicitly solve Maxwell’s equations in a simplified geometry and demonstrate that in this mass range, the axion-induced electric fields are heavily suppressed by boundary conditions. Unfortunately, experimentally measuring axion-induced electric fields is not feasible in this mass regime using the currently proposed setups with static primary fields. We show that at larger axion masses, induced electric fields are not suppressed, but boundary effects may still be relevant for an experiment’s sensitivity. We then make a general argument about a generic detector configuration with a static magnetic field to show that the electric fields are always suppressed in the limit of large wavelength.National Science Foundation (U.S.) (Award No. 1806440

The effects of space radiation on thin films of YBa2Cu3O(sub 7-x)

This investigation had two objectives: (1) to determine the effects of space radiation on superconductor parameters that are most important in space applications; and (2) to determine whether this effect can be simulated with Co-60 gamma rays, the standard test method for space materials. Thin films of yttrium barium copper oxide (YBCO) were formed by coevaporation of Y, BaF2, and Cu and post-annealing in wet oxygen at 850 C for 3.5 h. The substrate used was (100) silicon with an evaporated zirconia buffer layer. The samples were characterized by four point probe electrical measurements as a function of temperature. The parameters measured were the zero resistance transition temperature (T sub c) and the room temperature resistance. The samples were then exposed to Co-60 gamma-rays in air and in pure nitrogen, and to 780 keV electrons, in air. The parameters were then remeasured. The results are summarized. The results indicate little or no degradation in the parameters measured for samples exposed up to 10 Mrads of gamma-rays in nitrogen. However, complete degradation of samples exposed to 10-Mrad in air was observed. This degradation is preliminarily attributed to the high level of ozone generated in the chamber by the gamma-ray interaction with air. It can be concluded that: (1) the electron component of space radiation does not degrade the critical temperature of the YBCO films described, at least for energies around 800 keV and doses similar to those received by surface materials on spacecraft in typical remote sensing missions; and (2) for qualifying this and other superconducting materials against the space-radiation threat the standard test method in the aerospace industry, namely, exposure to Co-60 gamma-rays in air, may require some further investigation. As a minimum, the sample must be either in vacuum or in positive nitrogen pressure

The effects of space radiation on thin films of YBa2Cu3O(7-x)

This investigation had two objectives: (1) to determine the effects of space radiation on superconductor parameters that are most important in space applications; and (2) to determine whether this effect can be simulated with Co-60 gamma rays, the standard test method for space materials. Thin films of yttrium barium copper oxide (YBCO) were formed by coevaporation of Y, BaF2, and Cu and post-annealing in wet oxygen at 850 C for 3.5 h. The substrate used was (100) silicon with an evaporated zirconia buffer layer. The samples were characterized by four point probe electrical measurements as a function of temperature. The parameters measured were the zero resistance transition temperature T(sub c) and the room temperature resistance. The samples were then exposed to Co-60 gamma-rays in air and in pure nitrogen, and to 780 keV electrons, in air. The parameters were then remeasured. The results are summarized. The results indicate little or no degradation in the parameters measured for samples exposed up to 10 Mrads of gamma-rays in nitrogen. However, complete degradation is preliminarily attributed to the high level of ozone generated in the chamber by the gamma-ray interaction with air. It can be concluded that: (1) the electron component of space radiation does not degrade the critical temperature of the YBCO films described, at least for energies around 800 keV and doses similar to those received by surface materials on spacecraft in typical remote sensing missions; and (2) for qualifying this and other superconducting materials against the space-radiation threat the standard test method used in the aerospace industry, namely, exposure to Co-60 gamma-rays in air, may require some further investigation. As a minimum, the sample must be either in vacuum or in positive nitrogen pressure

Development of recurrent facial palsy during plasmapheresis in Guillain-Barré syndrome: a case report

Introduction: Guillain-Barré syndrome is an immune-mediated polyneuropathy that is routinely initially treated with either intravenous immunoglobulin or plasmapheresis. To the best of our knowledge, no association between plasmapheresis treatment and acute onset of facial neuropathy has been reported. Case presentation: A 35-year-old Caucasian man with no significant prior medical history developed ascending motor weakness and laboratory findings consistent with a diagnosis of Guillain-Barré syndrome. Plasmapheresis was initiated. Acute facial palsy developed during the plasma exchange that subsequently resolved and then acutely recurred during the subsequent plasma exchange. Conclusion: To the best of our knowledge, no prior cases of acute facial palsy developing during plasmapheresis treatment are known. Although facial nerve involvement is common in typical Guillain-Barré syndrome, the temporal association with treatment, near-complete resolution and later recurrence support the association. The possible mechanism of plasmapheresis-induced worsening of peripheral nerve function in Guillain-Barré syndrome is unknown

Newly synthesized proteins are degraded by an ATP-stimulated proteolytic process in isolated pea chloroplasts

AbstractUp to 22% of the [3H]leucine-labeled proteins synthesized chloroplasts in the light was degraded during subsequent incubation for 20–40 min. The degradation of these radioactive proteins was more rapid in the light than in the dark and was at least 2-fold greater in the presence of 5 mM ATP in light or darkness. Exogenous amino acids did not influence degradation rates, although they promoted protein synthesis. Overall, proteins from thylakoid and stromal fractions were degraded at comparable rates. Analysis by electrophoresis in denaturing polyacrylamide gels revealed that many proteins decreased in both fractions. Certain low molecular mass stromal proteins were lost almost completely during a 90 min incubation in the presence of ATP, while others were unaffected or decreased only slightly. Thus Chloroplasts, like eukaryotic and prokaryotic cells and mithochondria, contain an ATP-stimulated proteolytic system

The effect of temperature cycling typical of low earth orbit satellites on thin films of YBa2Cu3O(7-x)

The refrigeration of superconductors in space poses a challenging problem. The problem could be less severe if superconducting materials would not have to be cooled when not in use. Thin films of the YBa2Cu3O(7-x) (YBCO) superconductor were subjected to thermal cycling, which was carried out to simulate a large number of eclipses of a low earth orbit satellite. Electrical measurements were performed to find the effect of the temperature cycling. Thin films of YBCO were formed by coevaporation of Y, BaF2, and Cu and postannealing in wet oxygen at 850 C for 3.5 h. The substrates used were (100) SrTiO3, polycrystalline alumina, and oxidized silicon; the last two have an evaporated zirconia layer. Processing and microstructure studies of these types of films have been published. THe zero resistance transition temperatures of the samples used in this study were 91, 82, and 86 K, respectively. The samples were characterized by four point probe electrical measurements as a function of temperature. The parameters measured were: the zero resistance transition temperature, the 10 to 90 percent transition width, and the room temperature resistance, normalized to that measured before temperature cycling. The results for two samples are presented. Each sample had a cumulative exposure. Cycling in atmospheric pressure nitrogen was performed at a rate of about 60 cycles per day, whereas in vacuum the rate was only about 10 cycles per day. The results indicate only little or no changes in the parameters measured. Degradation of superconducting thin films of YBCO has been reported due to storage in nitrogen. It is believed that the relatively good performance of films after temperature cycling is related to the fact that BaF2 was used as an evaporation source. The latest result on extended temperature cycling indicates significant degradation. Further tests of extended cycling will be carried out to provide additional data and to clarify this preliminary finding

Low power arcjet system spacecraft impacts

Application of electrothermal arcjets on communications satellites requires assessment of integration concerns identified by the user community. Perceived risks include plume contamination of spacecraft materials, induced arcing or electrostatic discharges between differentially charged spacecraft surfaces, and conducted and radiated electromagnetic interference (EMI) for both steady state and transient conditions. A Space Act agreement between Martin Marietta Astro Space, the Rocket Research Company, and NASA's Lewis Research Center was established to experimentally examine these issues. Spacecraft materials were exposed to an arcjet plume for 40 hours, representing 40 weeks of actual spacecraft life, and contamination was characterized by changes in surface properties. With the exception of the change in emittance of one sample, all measurable changes in surface properties resulted in acceptable end of life characteristics. Charged spacecraft samples were benignly and consistently reduced to ground potential during exposure to the powered arcjet plume, suggesting that the arcjet could act as a charge control device on spacecraft. Steady state EMI signatures obtained using two different power processing units were similar to emissions measured in a previous test. Emissions measured in UHF, S, C, Ku and Ka bands obtained a null result which verified previous work in the UHF, S, and C bands. Characteristics of conducted and radiated transient emissions appear within standard spacecraft susceptibility criteria

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice

Integrins play an important role during development, regulating cell differentiation, proliferation and survival. Here we show that knockdown of integrin subunits slows down the progression of hepatocellular carcinoma (HCC). Using nanoparticulate delivery of short interfering RNAs targeting β1 and αv integrin subunits we downregulate all integrin receptors in hepatocytes. Short-term integrin knockdown (two weeks) does not cause apparent structural or functional perturbations of normal liver tissue. Alterations in liver morphology accumulate upon sustained integrin downregulation (seven weeks). The integrin knockdown leads to significant retardation of HCC progression, reducing proliferation and increasing tumour cell death. This tumour retardation is accompanied by reduced activation of MET oncogene as well as expression of its mature form on the cell surface. Our data suggest that transformed proliferating cells from HCC are more sensitive to knockdown of integrins than normal quiescent hepatocytes, highlighting the potential of siRNA-mediated inhibition of integrins as an anti-cancer therapeutic approach