Influence of vitamin K antagonist treatment on activated partial thromboplastin time

A

De bronconstructies van Belgisch Nederlands (’t) schijnt : een repliek

This is a brief reply to the article by Vliegen in this issue. We argue that, while Vliegen’s suggestion of a link between naar het schijnt and (’t) schijnt is certainly plausible, this need not rule out a scenario in which the emerging use of (’t) schijnt as a particle has also taken its root in (specific uses of) the matrix clause construction het schijnt dat. In modern construction-based approaches to language change, it is accepted that newly developing constructions may have multiple sources. In this perspective, the ‘matrix clause hypothesis’ and the ‘paratactic hypothesis’ are not mutually exclusive

On the grammaticalization of ('t) schijnt 'it seems' as an evidential particle in colloquial Belgian Dutch

Comparing ( ’t) schijnt to (zo) schijnt het (lit. ‘so seems it’), the parenthetical use of the verb schijnen ‘seem’, we argue that ( ’t) schijnt is best analysed as an evidential particle. Although both parenthetical and particle uses of schijnen have been subject to particulization, viz. grammaticalization towards particlehood, this grammaticalization path is bifurcated; while ( ’t) schijnt is best accounted for by the matrix clause hypothesis, (zo) schijnt het fits the parataxis hypothesis and is less grammaticalized, not having reached particle status yet. The possible further grammaticalization of (zo) schijnt het into a more particle-like element is discussed on the basis of recent developments in Netherlandic Dutch, suggesting that distinct grammaticalization paths may lead to similar outcomes. This study calls attention to the need to allow for a certain flexibility of categories when considering cases of grammaticalization such as those affecting schijnen, bearing in mind that each individual instance of ( ’t) schijnt or (zo) schijnt het can be more or less central to the idealized categories of matrix clause, parenthetical or particle

Psychological and cultural insights into consumption of luxury western brands in India

India has always had wealthy elites such as the maharajas, upper class and royalty that consume luxury products throughout its consumption history. The relatively recent economic rise of the middle class with an increase in disposable income is leading to consumption of luxury en mass. This qualitative study examines why consumers buy luxury, what they believe luxury is and how their perception of luxury impacts buying behaviour in the context of India. The present study explores luxury constructs drawn from the literature and provides some explanation for luxury consumption behaviour in India. The findings reveal that psychological and cultural factors in Indian society play a major part in shaping luxury consumption. While the findings suggest little support for homogenous luxury preference, Indian consumers share cultural characteristics of lavish consumption of luxury and display of wealth in social functions. Luxury reflects conspicuous consumption and status, and signals wealth for individuals, and conveys social identity and status in Indian society

The diachronic development of zero complementation: A multifactorial analysis of the that/zero alternation with think, suppose, and believe

This corpus-based study examines the diachronic development of the that/zero alternation with three verbs of cognition, viz. think, believe, and suppose by means of a stepwise logistic regression analysis. The data comprised a total of (n = 9,720) think, (n = 4,767) believe, and (n = 4,083) suppose tokens from both spoken and written corpora from 1560 to 2012. We test the effect of 11 structural features that have been claimed to predict the presence of the zero complementizer form. Taking our cue from previous research suggesting that there has been a diachronic increase in zero use and applying a rigorous quantitative method to a large set of diachronic data, we examine (i) whether there is indeed a diachronic trend toward more zero use, (ii) whether the conditioning factors proposed in the literature indeed predict the zero form, (iii) to what extent these factors interact, and (iv) whether the predictive power of the conditioning factors becomes stronger or weaker over time. The analysis shows that, contrary to the aforementioned belief that the zero form has been on the increase, there is in fact a steady decrease in zero use. The extent of this decrease is not the same for all verbs. Also, the analysis of interactions with verb type indicates differences between verbs in terms of the predictive power of the conditioning factors. Additional significant interactions emerged, notably with verb, mode (i.e., spoken or written data), and period. The interactions with period show that certain factors that are good predictors of the zero form overall lose predictive power over time

Anatomic features underlying wood density, in 110 rainforest tree species from central Congo basin

Investigate the influence of fiber thickness and vessel diameter on the wood density in 110 rainforest tree species, and the relationships between wood density, wood water content and shrinking ratio.COBIMF

Early-onset primary antibody deficiency resembling common variable immunodeficiency challenges the diagnosis of Wiedeman-Steiner and Roifman syndromes

Syndromic primary immunodeficiencies are rare genetic disorders that affect both the immune system and other organ systems. More often, the immune defect is not the major clinical problem and is sometimes only recognized after a diagnosis has been made based on extra-immunological abnormalities. Here, we report two sibling pairs with syndromic primary immunodeficiencies that exceptionally presented with a phenotype resembling early-onset common variable immunodeficiency, while extra-immunological characteristics were not apparent at that time. Additional features not typically associated with common variable immunodeficiency were diagnosed only later, including skeletal and organ anomalies and mild facial dysmorphism. Whole exome sequencing revealed KMT2-Aassociated Wiedemann-Steiner syndrome in one sibling pair and their mother. In the other sibling pair, targeted testing of the known disease gene for Roifman syndrome (RNU4ATAC) provided a definite diagnosis. With this study, we underline the importance of an early-stage and thorough genetic assessment in paediatric patients with a common variable immunodeficiency phenotype, to establish a conclusive diagnosis and guide patient management. In addition, this study extends the mutational and immunophenotypical spectrum of Wiedemann-Steiner and Roifman syndromes and highlights potential directions for future pathophysiological research

Metabolic Control Analysis in a Cellular Model of Elevated MAO-B: Relevance to Parkinson’s Disease

We previously demonstrated that spare respiratory capacity of the TCA cycle enzyme alpha-ketoglutarate dehydrogenase (KGDH) was completely abolished upon increasing levels of MAO-B activity in a dopaminergic cell model system (Kumar et al., J Biol Chem 278:46432–46439, 2003). MAO-B mediated increases in H2O2 also appeared to result in direct oxidative inhibition of both mitochondrial complex I and aconitase. In order to elucidate the contribution that each of these components exerts over metabolic respiratory control as well as the impact of MAO-B elevation on their spare respiratory capacities, we performed metabolic respiratory control analysis. In addition to KGDH, we assessed the activities and substrate-mediated respiration of complex I, pyruvate dehydrogenase (PDH), succinate dehydrogenase (SDH), and mitochondrial aconitase in the absence and presence of complex-specific inhibitors in specific and mixed substrate conditions in mitochondria from our MAO-B elevated cells versus controls. Data from this study indicates that Complex I and KGDH are the most sensitive to inhibition by MAO-B mediated H2O2 generation, and could be instrumental in determining the fate of mitochondrial metabolism in this cellular PD model system