701 research outputs found
Book Review: Ould Fields, New Corne: The Personal Memoirs of a Twentieth Century Lawyer
Erwin Griswold, the former dean of Harvard Law School and Solicitor General of the United States, has written a very modest account of his role in shaping American law
Experimental Investigation of the U238 Resonance Neutron Capture Integral of Uranium Carbide Clustered Fuel Elements Containing Moderating Coolants. EUR 3152.
A MEASUREMENT OF THE FINE STRUCTURE OF THE THERMAL FLUX IN SIMPLE-GEOMETRY ORGEL TYPE LATTICES. EUR 206.e
Waveguide-coupled detector in zero-change complementary metal–oxide–semiconductor
We report a waveguide-coupled photodetector realized in a standard CMOS foundry without requiring changes to the process flow (zero-change CMOS). The photodetector exploits carrier generation in the silicon-germanium normally utilized as stressor in pFETs. The measured responsivity and 3 dB bandwidth are of 0.023 A/W at a wavelength of 1180 nm and 32 GHz at −1 V bias (18 GHz at 0 V bias). The dark current is less than 10 pA and the dynamic range is larger than 60 dB.United States. Defense Advanced Research Projects Agency. Photonically Optimized Embedded Microprocessors Program (Award HR0011-11-C-0100)United States. Defense Advanced Research Projects Agency. Photonically Optimized Embedded Microprocessors Program (Contract HR0011-11-9-0009
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the goal of this study is to determine whether HDI can also enhance the potency of these poxviruses in infection-resistant cancer cell lines. Multiple HDIs were tested and Trichostatin A (TSA) was found to potently enhance the spread and replication of a tumour selective vaccinia virus in several infection-resistant cancer cell lines. TSA significantly decreased the number of lung metastases in a syngeneic B16F10LacZ lung metastasis model yet did not increase the replication of vaccinia in normal tissues. The combination of TSA and VV increased survival of mice harbouring human HCT116 colon tumour xenografts as compared to mice treated with either agent alone. We conclude that TSA can selectively and effectively enhance the replication and spread of oncolytic vaccinia virus in cancer cells. © 2010 MacTavish et al
Polarization Control of the Non-linear Emission on Semiconductor Microcavities
The degree of circular polarization () of the non-linear emission in
semiconductor microcavities is controlled by changing the exciton-cavity
detuning. The polariton relaxation towards \textbf{K} cavity-like
states is governed by final-state stimulated scattering. The helicity of the
emission is selected due to the lifting of the degeneracy of the spin
levels at \textbf{K} . At short times after a pulsed excitation
reaches very large values, either positive or negative, as a result of
stimulated scattering to the spin level of lowest energy ( spin for
positive/negative detuning).Comment: 8 pages, 3 eps figures, RevTeX, Physical Review Letters (accepted
New combined PIC-MCC approach for fast simulation of a radio frequency discharge at low gas pressure
A new combined PIC-MCC approach is developed for accurate and fast simulation
of a radio frequency discharge at low gas pressure and high density of plasma.
Test calculations of transition between different modes of electron heating in
a ccrf discharge in helium and argon show a good agreement with experimental
data.
We demonstrate high efficiency of the combined PIC-MCC algorithm, especially
for the collisionless regime of electron heating.Comment: 6 paged, 8 figure
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