Is somatostatin receptor scintigraphy suited to detection of acute infectious disease?

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Supply Chain Disruption Costs Study in International Containerised Maritime Transportation

The global economy relies highly on international trade, and the international maritime transport system acts as the lifeblood carrying and transporting materials and goods globally, realizing the economy globalization in an effective and efficient way. However, globalization increases the interdependence and complexity of global supply chains and drives it to be more vulnerable to disruptions. Meanwhile, the international marine transport system is a complex and intertwined system exposed to high risks and decreased safety due to its very accessibility and operational flexibility. Thereby, global supply chains integrated with international maritime transportation systems are inherently vulnerable to various disruptions. Studies of supply chain disruptions particularly quantifying transport related disruption costs are becoming increasingly important. However, research on maritime transport related supply chain disruptions, in particular, quantifying its disruption costs is under-represented in the transport literature, due largely to the features of supply chain disruptions, but also because of the complexity of maritime related supply chains. Current research in transportation has tended to concentrate on shippers’ transport mode choice and port selection. In the context of a global market, however, the behaviour of maritime containerised shippers has to be viewed as a complex decision and an integral element of the supply chain management strategy. Those shippers’ transportation choice decisions should be emphasized and studied to reveal their behaviour changes between normal operations and disruption circumstance. This research adds to the paucity work on investigating the maritime transport related supply chain disruptions and quantifying its disruption costs based on shippers’ maritime transportation choice behaviour. It presents the results of a microanalysis of freight transport choice decisions in an international containerised maritime transport chain context. The Latent Class Model (LCM) is applied to identify the key service attributes and its preference heterogeneity in maritime transportation and to estimate the marginal values for the quality of maritime transport service with and without a disruption, simultaneously, quantifying the disruption costs through comparing each attribute’s marginal value difference between normal and disruption operations. The Seemingly Unrelated Regression model (SURE) is utilized to explore the sources influencing shippers’ preference heterogeneities. In doing so, we are able to gain an understanding as to where and how much should be invested in order to facilitate recovery in the case of a disruption based on the view of the maritime participants’ perspectives. The research results confirm freight rate, transit time, reliability, damage rate, and frequency as the key service attributes influencing shippers’ transport choice. They also reveal shippers’ VOT increase by more than four-times, VOR nearly double, and VOD increase about twenty percent if a disruption takes place, and identify shippers’ transport decisions vary with its product, shipment, company and supply chain characteristics no matter with or without a disruption. This research quantifies the costs of supply chain disruption in containerised maritime transport context for the first time, and its results provide useful industrial implications for maritime transport chain related parties

‘With Friends Like These’: Human Rights, Neoconservatism and U.S. Foreign Policy from Carter to Reagan.

This thesis engages with two emerging bodies of scholarship: the history of human rights and the history of U.S. neoconservatism. It begins with an exploration of the genesis of the contemporary international human rights movement, arguing that human rights as we know and understand them today were a product of the latter half of the twentieth century. Their path, however, was not a clear one. The emergence of neoconservative ideology in U.S. domestic politics would greatly impact upon the trajectory of the human rights movement under the presidencies of Jimmy Carter and Ronald Reagan. The latter period witnessed a conflict between America’s Watch and the Reagan administration over human rights as an ‘idea’ and as praxis, with U.S. policy towards Latin America as the primary battle field

Statistical analysis of the features of diatonic music with jMusic

Much has been written about the rules of melody writing and this paper reports research that uses computer-based statistical analysis to test the efficacy of these rules. As a method to assist in the computer generation of melodies, we have devised computer software that analyses melodic features. This paper will outline the melodic features identified in melody-writing literature and the results of their fit with our statistical analysis of melodies from the western music repertoire. We will also present details of the computer-based analysis software and the jMusic software environment in which it was built. The software and jMusic environment are open source software projects that are freely available, and so opportunities to develop these tools to suit other music analysis tasks will be discussed.Hosted by the Scholarly Text and Imaging Service (SETIS), the University of Sydney Library, and the Research Institute for Humanities and Social Sciences (RIHSS), the University of Sydney

Biodistribution of 111In-labelled IgG and IgM in experimental infection

Contains fulltext : 4841.pdf (publisher's version ) (Open Access

Dissociation of indium from indium-111-labelled diethylene triamine penta-acetic acid conjugated non-specific polyclonal human immunoglobulin G in inflammatory foci

Contains fulltext : 4796.pdf (publisher's version ) (Open Access

Varietal differences in protein polymer built-up of wheat at different temperature and nitrogen regimes during grain filling

Both radionuclide imaging and near-infrared fluorescent (NIRF) imaging have a high sensitivity to detect tumors in vivo. The combination of these modalities using dual-labeled antibodies may allow both preoperative and intraoperative tumor localization and may be used in image-guided surgery to ensure complete resection of tumor tissue. Here, we evaluated the potential of dual-modality imaging of prostate cancer with the monoclonal antibody D2B, directed against an extracellular domain of prostate-specific membrane antigen (PSMA). For these studies, D2B was labeled both with (111)In and with the NIRF dye IRDye800CW.D2B was conjugated with N-hydroxysuccinimide-IRDye800CW and p-isothiocyanatobenzyl-diethylenetriaminepentaacetic acid (ITC-DTPA) and subsequently radiolabeled with (111)In. For biodistribution and NIRF imaging, (111)In-DTPA-D2B-IRDye800CW (2 μg, 0.55 MBq/mouse) was injected intravenously into BALB/c nude mice with subcutaneous PSMA-expressing LNCaP tumors (right flank) and PSMA-negative PC3 tumors (left flank). The biodistribution was determined at 1, 2, 3, and 7 d after injection. In addition, micro-SPECT/CT and NIRF imaging with (111)In-DTPA-D2B-IRDye800CW (3 μg, 8.5 MBq/mouse) was performed on mice with intraperitoneally growing LS174T-PSMA tumors.(111)In-DTPA-D2B-IRDye800CW specifically accumulated in subcutaneous PSMA-positive LNCaP tumors (45.8 ± 8.0 percentage injected dose per gram at 168 h after injection), whereas uptake in subcutaneous PSMA-negative PC3 tumors was significantly lower (6.6 ± 1.3 percentage injected dose per gram at 168 h after injection). Intraperitoneal LS174T-PSMA tumors could be visualized specifically with both micro-SPECT/CT and NIRF imaging at 2 d after injection, and the feasibility of image-guided resection of intraperitoneal tumors was demonstrated in this model.Dual-labeled (111)In-DTPA-D2B-IRDye800CW enables specific and sensitive detection of prostate cancer lesions in vivo with micro-SPECT/CT and NIRF imaging. In addition to preoperative micro-SPECT/CT imaging to detect tumors, NIRF imaging enables image-guided surgical resection. These preclinical findings warrant clinical studies with (111)In-DTPA-D2B-IRDye800CW to improve tumor detection and resection in prostate cancer patients

Sterically stabilized liposomes labeled with Indium-111 to image focal infection

Contains fulltext : 21192___.pdf (publisher's version ) (Open Access

Labelled StealthR liposomes in experimental infection : an alternative to leukocyte scintigraphy?

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Specific targeting of infectious foci with radioiodinated human recombinant interleukin-1 in an experimental model

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