260 research outputs found
Langevin description of speckle dynamics in nonlinear disordered media
We formulate a Langevin description of dynamics of a speckle pattern
resulting from the multiple scattering of a coherent wave in a nonlinear
disordered medium. The speckle pattern exhibits instability with respect to
periodic excitations at frequencies below some
, provided that the nonlinearity exceeds some
-dependent threshold. A transition of the speckle pattern from a
stationary state to the chaotic evolution is predicted upon increasing
nonlinearity. The shortest typical time scale of chaotic intensity fluctuations
is of the order of .Comment: 6 pages, 3 figure
Seasonal diet changes in elephant and impala in mopane woodland
Elephant and impala as intermediate feeders, having a mixed diet of grass and browse, respond to seasonal fluctuations of forage quality by changing their diet composition. We tested the hypotheses that (1) the decrease in forage quality is accompanied by a change in diet from more monocots in the wet season to more dicots in the dry season and that that change is more pronounced and faster in impala than in elephant; (2) mopane (Colophospermum mopane), the most abundant dicot species, is the most important species in the elephant diet in mopane woodland, whereas impala feed relatively less on mopane due to the high condensed tannin concentration; and (3) impala on nutrient-rich soils have a diet consisting of more grass and change later to diet of more browse than impala on nutrient-poor soils. The phosphorus content and in vitro digestibility of monocots decreased and the NDF content increased significantly towards the end of the wet season, whereas in dicots no significant trend could be detected. We argue that this decreasing monocot quality caused elephant and impala to consume more dicots in the dry season. Elephant changed their diet gradually over a 16-week period from 70% to 25% monocots, whereas impala changed diets rapidly (2-4 weeks) from 95% to 70% monocots. For both elephants and impala, there was a positive correlation between percentage of monocots and dicots in the diet and the in vitro digestibility of these forage items. Mopane was the most important dicot species in the elephant diet and its contribution to the diet increased significantly in the dry season, whereas impala selected other dicot species. On nutrient-rich gabbroic soils, impala ate significantly more monocots than impala from nutrient-poor granitic soils, which was related to the higher in vitro digestibility of the monocots on gabbroic soil. Digestibility of food items appears to be an important determinant of diet change from the wet to the dry season in impala and elephants
Random migration and signal integration promote rapid and robust T cell recruitment
FWN – Publicaties zonder aanstelling Universiteit Leide
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration
Toxicolog
Temporal fluctuations of waves in weakly nonlinear disordered media
We consider the multiple scattering of a scalar wave in a disordered medium
with a weak nonlinearity of Kerr type. The perturbation theory, developed to
calculate the temporal autocorrelation function of scattered wave, fails at
short correlation times. A self-consistent calculation shows that for
nonlinearities exceeding a certain threshold value, the multiple-scattering
speckle pattern becomes unstable and exhibits spontaneous fluctuations even in
the absence of scatterer motion. The instability is due to a distributed
feedback in the system "coherent wave + nonlinear disordered medium". The
feedback is provided by the multiple scattering. The development of instability
is independent of the sign of nonlinearity.Comment: RevTeX, 15 pages (including 5 figures), accepted for publication in
Phys. Rev.
Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) in infants is characterized by
rearrangements of the mixed lineage leukemia (MLL) gene, drug resistance,
and a poor treatment outcome. Therefore, novel therapeutic strategies are
needed to improve prognosis. Recently, we showed that FLT3 is highly
expressed in MLL rearranged ALL (MLL). Here we demonstrate FLT3 expression
in infants with MLL (n = 41) to be significantly higher compared to both
infant (n = 8; P < .001) and noninfant patients with ALL (n = 23; P =
.001) carrying germline MLL genes. Furthermore, leukemic cells from
infants with MLL were significantly more sensitive to the Fms-like
tyrosine kinase 3 (FLT3) inhibitor PKC412 (N-benzoyl staurosporine) than
noninfant ALL cells, and at least as sensitive as internal tandem
duplication-positive (ITD+) AML cells. Surprisingly, activation loop
mutations only occurred in about 3% (1 of 36) of the cases and no
FLT3/ITDs were observed. However, measuring FLT3 phosphorylation in
infants with MLL expressing varying levels of wild-type FLT3 revealed that
high-level FLT3 expression is associated with ligand-independent FLT3
activation. This suggests that infant MLL cells displaying activated FLT3
as a result of overexpression can be targeted by FLT3 inhibitors such as
PKC412. However, at concentrations of PKC412 minimall
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