Genetic variants and the metabolic syndrome: a systematic review

Several candidate gene studies on the metabolic syndrome (MetS) have been conducted. However, for most single nucleotide polymorphisms (SNPs) no systematic review on their association with MetS exists. A systematic electronic literature search was conducted until the 2nd of June 2010, using HuGE Navigator. English language articles were selected. Only genes of which at least one SNP–MetS association was studied in an accumulative total population =4000 subjects were included. Meta-analyses were conducted on SNPs with three or more studies available in a generally healthy population. In total 88 studies on 25 genes were reviewed. Additionally, for nine SNPs in seven genes (GNB3, PPARG, TCF7L2, APOA5, APOC3, APOE, CETP) a meta-analysis was conducted. The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. After having systematically reviewed the most studied SNP–MetS associations, we found evidence for an association with the MetS for eight SNPs, mostly located in genes involved in lipid metabolis

On hardware for generating routes in Kautz digraphs

In this paper we present a hardware implementation of an algorithm for generating node disjoint routes in a Kautz network. Kautz networks are based on a family of digraphs described by W.H. Kautz[Kautz 68]. A Kautz network with in-degree and out-degree d has N = dk + dk¿1 nodes (for any cardinals d, k>0). The diameter is at most k, the degree is fixed and independent of the network size. Moreover, it is fault-tolerant, the connectivity is d and the mapping of standard computation graphs such as a linear array, a ring and a tree on a Kautz network is straightforward.\ud The network has a simple routing mechanism, even when nodes or links are faulty. Imase et al. [Imase 86] showed the existence of d node disjoint paths between any pair of vertices. In Smit et al. [Smit 91] an algorithm is described that generates d node disjoint routes between two arbitrary nodes in the network. In this paper we present a simple and fast hardware implementation of this algorithm. It can be realized with standard components (Field Programmable Gate Arrays)

Linoleic acid intake, plasma cholesterol and 10-year incidence of CHD in 20.000 middle-aged men and women in the Netherlands

We studied the associations of a difference in linoleic acid or carbohydrate intake with plasma cholesterol levels and risk of CHD in a prospective cohort study in the Netherlands. Data on diet (FFQ) and plasma total and HDL-cholesterol were available at baseline (1993–7) of 20 069 men and women, aged 20–65 years, who were initially free of CVD. Incidence of CHD was assessed through linkage with mortality and morbidity registers. During an average of 10 years of follow-up, 280 CHD events occurred. The intake of linoleic acid ranged from 3·6 to 8·0 % of energy (en%), whereas carbohydrate intake ranged from 47·6 to 42·5 en% across quintiles of linoleic acid intake. Linoleic acid intake was inversely associated with total cholesterol and HDL-cholesterol in women but not in men. Linoleic acid intake was not associated with the ratio of total to HDL-cholesterol. No association was observed between linoleic acid intake and CHD incidence, with hazard ratios varying between 0·83 and 1·00 (all P>0·05) compared to the bottom quintile. We conclude that a 4–5 en% difference in linoleic acid or carbohydrate intake did not translate into either a different ratio of total to HDL-cholesterol or a different CHD incidenc

Design optimization applied in structural dynamics

This paper introduces the design optimization strategies, especially for structures which have dynamic constraints. Design optimization involves first the modeling and then the optimization of the problem. Utilizing the Finite Element (FE) model of a structure directly in an optimization process requires a long computation time. Therefore the Backpropagation Neural Networks (NNs) are introduced as a so called surrogate model for the FE model. Optimization techniques mentioned in this study cover the Genetic Algorithm (GA) and the Sequential Quadratic Programming (SQP) methods. For the applications of the introduced techniques, a multisegment cantilever beam problem under the constraints of its first and second natural frequency has been selected and solved using four different approaches

Sources of dietary protein and risk of hypertension in a general Dutch population

Evidence suggests a small beneficial effect of dietary protein on blood pressure (BP), especially for plant protein. We examined the relationship between several types of dietary protein (total, plant, animal, dairy, meat and grain) and the risk of hypertension in a general population of 3588 Dutch adults, aged 26–65 years, who were free of hypertension at baseline. Measurements were done at baseline and after 5 and 10 years of follow-up. Hazard ratios (HR), with 95 % CI, for incident hypertension were obtained in tertiles of energy-adjusted protein, using time-dependent Cox regression models. Models were adjusted for age, sex, BMI, education, smoking, baseline systolic BP, dietary confounders and protein from other sources (if applicable). Mean BP was 118/76 mmHg at baseline. Protein intake was 85 (sd 22) g/d (approximately 15 % of energy) with 62 % originating from animal sources. The main sources of protein were dairy products (28 %), meat (24 %) and grain (19 %). During the follow-up, 1568 new cases of hypertension were identified (44 % of the participants). Energy-adjusted intake of total protein, plant protein and animal protein was not significantly associated with hypertension risk (all HR approximately 1·00, P>0·60). Protein from grain showed a significant inverse association with incident hypertension, with a HR of 0·85 (95 % CI 0·73, 1·00, Ptrend = 0·04) for the upper tertile ( = 18 g/d) v. the lower tertile ( <14 g/d), whereas dairy protein and meat protein were not associated with incident hypertension. In conclusion, higher intake of grain protein may contribute to the prevention of hypertension, which warrants confirmation in other population-based studies and randomised controlled trials

Remarks on Finite W Algebras

The property of some finite W algebras to be the commutant of a particular subalgebra of a simple Lie algebra G is used to construct realizations of G. When G=so(4,2), unitary representations of the conformal and Poincare algebras are recognized in this approach, which can be compared to the usual induced representation technique. When G=sp(2,R) or sp(4,R), the anyonic parameter can be seen as the eigenvalue of a W generator in such W representations of G. The generalization of such properties to the affine case is also discussed in the conclusion, where an alternative of the Wakimoto construction for sl(2) level k is briefly presented. This mini review is based on invited talks presented by P. Sorba at the ``Vth International Colloquium on Quantum Groups and Integrable Systems'', Prague (Czech Republic), June 1996; ``Extended and Quantum Algebras and their Applications to Physics'', Tianjin (China), August 1996; ``Selected Topics of Theoretical and Modern Mathematical Physics'', Tbilisi (Georgia), September 1996; to be published in the Proceedings.Comment: LaTeX, 16 pages, references adde

Environmental impact assessment of dietary scenarios: a comparison of methodological aspects

Background Dietary patterns have manifold impacts on the environment. • However, studies that assess dietary patterns operate with varying methodological approaches and underlying assumptions, which evoke different, and occasionally even contradicting, results. • This leads to uncertainty regarding what should or should not be eaten, especially with regard to animal-source food (ASF) and production types (e.g. conventional or organic). • Therefore, to adequately interpret results, it is necessary to interpret these in the context of the respective methods used and assumptions made

The development of a resource-efficient photovoltaic system

This paper presents the measures taken in the demonstration of the photovoltaic case study developed within the European project ‘Towards zero waste in industrial networks’ (Zerowin), integrating the D4R (Design for recycling, repair, refurbishment and reuse) criteria at both system and industrial network level. The demonstration is divided into three phases. The first phase concerns the development of a D4R photovoltaic concept, the second phase focused on the development of a specific component of photovoltaic systems and the third phase was the demonstration of the D4R design in two complete photovoltaic systems (grid-connected and stand-alone). This paper includes a description of the installed photovoltaic systems, including a brief summary at component level of the lithium ion battery system and the D4R power conditioning system developed for the pilot installations. Additionally, industrial symbioses within the network associated with the photovoltaic systems and the production model for the network are described