Trimethoprim-sulfamethoxazole induced toxic epidermal necrolysis: a case report

Toxic epidermal necrolysis (TEN) is a rare but serious dermatological disorder commonly caused as an idiosyncratic reaction to drugs and the most common drugs implicated are antibiotics, anticonvulsants and non-steroidal anti-inflammatory drugs. Here, we report a case of trimethoprim-sulfamethoxazole induced TEN in a 26 years old female

Aspirin induced fixed drug eruptions: a case report

Fixed drug eruptions are common cutaneous adverse drug reactions, commonly caused by anticonvulsants, antibiotics and analgesics. Here, we report a case of a 27-year-old male of fixed drug eruptions due to Aspirin which was used in treatment of headache

Facile ZnO NPs catalyzed synthesis of substituted 4-amino-6-(1H-benzimidazol-2-ylsulfanyl)benzene-1,3-dicarbonitrile new derivatives as Potent biological agents

This study focuses on the efficient synthesis of series of substituted 4-amino-6-(1H-benzimidazol-2-ylsulfanyl) benzene-1,3-dicarbonitrile derivatives synthesized from aldehydes, propanedinitrile, substituted thiols and catalyzed by ZnO nanoparticles (ZnONPs). All the synthesized compounds have been characterized using different spectroscopic techniques such as FT-IR, 1H-NMR, C13-NMR and Mass. The compounds were evaluated for potential pharmacological applications, including antimicrobial, α-amylase inhibitory and anticancer activities. Computational calculations, DFT, in-silico molecular docking, and ADME-toxicologystudies were performed. ADMET studies indicated that all synthesized compounds adhered to Rule of five with good bioavailability. This research underscores the promising pharmacological prospects of the synthesized newbenzimidazole derivatives

Crystallographic and optical studies on Cr doped ZnS nanocrystals

Chromium doped ZnS nanocrystals with pure and 10% compositions were synthesized by chemical co-precipitation route. Samples were characterized by X-ray diffraction (XRD) technique, Fourier transforms infrared spectroscopy (FTIR) and UV-Visible spectrometer. Lattice parameter 'a' decreases and grain size increases with increasing Cr concentration. XRD study shows that both the samples have cubic structure. Grain size increases due to ionic radius. The functional groups and chemical species of Cr doped ZnO samples were determined using FTIR data. UV-Vis study revealed that red shift is clearly observed in absorption band. Surface morphology of pure and 10% Cr doped samples was investigated by SEM technique and it is confirmed that images exibit cubic form of the samples. Using EDS, percentage of chemical compositions of material recorded

Comparative study on zinc oxide nanocrystals synthesized by two precipitation methods

Abstract Zinc oxide nanocrystals were synthesized by two precipitation methods successfully. The nanocrystals prepared via method I (zinc acetate dihydrate precipitation with KOH) were smaller in crystallite size (~20 nm) as compared to method II (zinc nitrate hexahydrate precipitation with N,N-dimethylformamide, ~33 nm). FTIR technique was used to study chemical bonding; SEM and EDS were used to study morphology and chemical compositions. Number of concentric rings corresponding to diffraction peaks was higher in SAED pattern for ZnO nanocrystals synthesized by method I than II. Variation in the energy band gap as a function of particle size was determined using absorption spectra from UV-vis-NIR spectrophotometer. Redshift was observed in the energy band gap of sample prepared via method II. Particle size and the structure of the nanocrystals were analysed by transmission electron microscope (TEM). From TEM study, it was found that the average particle size of method I nanocrystals was smaller compared to method II nanocrystals. Magnetic study was carried out using VSM. Ferromagnetism like contribution was observed for the sample prepared by method II

Synthesis of some 2, 6-bis (1-coumarin-2-yl)-4-(4-substituted phenyl) pyridine derivatives as potent biological agents

A convenient one-pot, three-component synthesis of 2, 6-bis (1-coumarin-2-yl)-4-(4-substituted phenyl) pyridine derivatives (3a–k) by Chichibabin reaction has been reported. These compounds were synthesized by the reaction of 3-acetyl coumarin (1a) or 5-bromo 3-acetyl coumarin (1b) with substituted aromatic aldehydes (2a–k) and ammonium acetate under acidic conditions and the structure was confirmed by FT-IR, 1H NMR, 13C NMR and Mass spectroscopic methods. The newly synthesized compounds (3a–k) were evaluated for antimicrobial activity, DPPH free radical scavenging activity and ferrous ion-chelating ability. The mode of action of these active compounds was carried out by docking receptor GlcN6P synthase. Compounds 3a, 3b, 3c, and 3d have displayed potential antimicrobial activity and some of the compounds have shown promising antioxidant properties

Synthesis, characterization, and biological investigations of potentially bioactive heterocyclic compounds containing benzimidazole nucleus

Six benzimidazole derivatives have been synthesized and characterized using spectroscopic techniques such as IR, 1H NMR, 13C NMR, and mass spectrometry. The computational calculations and geometrical optimization of newly synthesized benzimidazole derivatives were investigated using Gaussian software in conjunction with the Density functional theory (DFT)/B3LYP method with a 6–311++G(d,p) basis set at gaseous phase. In addition, the quantum chemical parameters of the compounds were evaluated to comprehend the structural activity concept. The synthesized compounds were tested for cytotoxicity using the MTT assay and antioxidant activity using the DPPH scavenging activity and the Ferrous-Ion Chelating Assay. All the compounds tested showed antioxidant, antidibetic, cytotoxic potential, with compounds 4c and 4f being the best of all derivatives. The agar diffusion method was used to conduct antimicrobial assays for bacteria and fungi. Even though none of the compounds were found to be effective against fungi isolates and some had a poor anti-bacterial effect, compound 4f had a significantly higher antibacterial effect against all bacteria strains (S. aureus, Bacillus cereus, E. coli, and Acetobacter sp.). Furthermore, in vitro anticancer properties of synthesized compounds were validated using in silico molecular docking simulation studies. Compound 4c had the highest binding affinity of all the ligands, with a binding energy of −5.9 Kcal/mol and three hydrogen bonds