Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear DNA-binding protein that participates in the regulation of DNA repair and maintenance of genomic integrity. In addition, PARP-1 has a role in several models of inflammation disease, where its absence or inactivation confers protection. The aim of this study was to analyze the impact of selective PARP-1 suppression in collagen antibody-induced arthritis. We show that PARP-1 deficiency partially reduces the severity of arthritis, although the incidence of disease was similar in control and deficient mice. Decreased clinical scores were accompanied by partial reduction of histopathological findings. Interestingly, quantitative real-time PCR and ELISA analysis revealed that the absence of PARP-1 down-regulated IL-1β and monocyte chemotactic protein 1 expression in arthritic joints whereas tumor necrosis factor-α transcription was not impaired. Our results provide evidence of the contribution of PARP-1 to the progression of arthritis and identify this protein as a potential therapeutic target for the treatment of rheumatoid arthritis

Historic eruption of Tromen volcano: Geomorphologic and geochronological analysis on its northwestern area

Se estudiaron los productos más jóvenes del volcán Tromen en su sector NO. En base al análisis de reportes históricos en conjunto con datos geomorfológicos y una edad radiocarbono, se determinó que los últimos períodos de actividad del volcán Tromen son posteriores a 1400 d.C. Dos ciclos eruptivos constituidos por fenómenos de baja peligrosidad volcánica fueron registrados. El primero tuvo lugar entre los años 1400 y 1751 d.C. y el último entre 1820 y 1828 d.C. Los resultados obtenidos presentan relevancia para la evaluación del riesgo volcánico de las poblaciones cercanas.The youngest volcanic deposits of the NW flank of Tromen Volcano (Neuquén Province, Argentina) were addressed. Based on the analysis of historical reports, combined with geomorphologic and radiocarbon age determinations, the age of the volcanic activity was constrained to be younger than 1400 AD. Two volcanic cycles were recorded within this period, both constituted by low volcanic hazard products. The first one occurred between 1440 - 1751 AD, whereas the second one developed from 1820 to 1828 AD. The results of this work have relevance for the assessment of volcanic risk in the nearby townsCentro de Investigaciones GeológicasInstituto de Recursos MineralesFacultad de Ciencias Naturales y MuseoConsejo Nacional de Investigaciones Científicas y Técnica

Historic eruption of Tromen volcano: Geomorphologic and geochronological analysis on its northwestern area

Se estudiaron los productos más jóvenes del volcán Tromen en su sector NO. En base al análisis de reportes históricos en conjunto con datos geomorfológicos y una edad radiocarbono, se determinó que los últimos períodos de actividad del volcán Tromen son posteriores a 1400 d.C. Dos ciclos eruptivos constituidos por fenómenos de baja peligrosidad volcánica fueron registrados. El primero tuvo lugar entre los años 1400 y 1751 d.C. y el último entre 1820 y 1828 d.C. Los resultados obtenidos presentan relevancia para la evaluación del riesgo volcánico de las poblaciones cercanas.The youngest volcanic deposits of the NW flank of Tromen Volcano (Neuquén Province, Argentina) were addressed. Based on the analysis of historical reports, combined with geomorphologic and radiocarbon age determinations, the age of the volcanic activity was constrained to be younger than 1400 AD. Two volcanic cycles were recorded within this period, both constituted by low volcanic hazard products. The first one occurred between 1440 - 1751 AD, whereas the second one developed from 1820 to 1828 AD. The results of this work have relevance for the assessment of volcanic risk in the nearby townsCentro de Investigaciones GeológicasInstituto de Recursos MineralesFacultad de Ciencias Naturales y MuseoConsejo Nacional de Investigaciones Científicas y Técnica

Historic eruption of Tromen volcano: Geomorphologic and geochronological analysis on its northwestern area

Se estudiaron los productos más jóvenes del volcán Tromen en su sector NO. En base al análisis de reportes históricos en conjunto con datos geomorfológicos y una edad radiocarbono, se determinó que los últimos períodos de actividad del volcán Tromen son posteriores a 1400 d.C. Dos ciclos eruptivos constituidos por fenómenos de baja peligrosidad volcánica fueron registrados. El primero tuvo lugar entre los años 1400 y 1751 d.C. y el último entre 1820 y 1828 d.C. Los resultados obtenidos presentan relevancia para la evaluación del riesgo volcánico de las poblaciones cercanas.The youngest volcanic deposits of the NW flank of Tromen Volcano (Neuquén Province, Argentina) were addressed. Based on the analysis of historical reports, combined with geomorphologic and radiocarbon age determinations, the age of the volcanic activity was constrained to be younger than 1400 AD. Two volcanic cycles were recorded within this period, both constituted by low volcanic hazard products. The first one occurred between 1440 - 1751 AD, whereas the second one developed from 1820 to 1828 AD. The results of this work have relevance for the assessment of volcanic risk in the nearby townsCentro de Investigaciones GeológicasInstituto de Recursos MineralesFacultad de Ciencias Naturales y MuseoConsejo Nacional de Investigaciones Científicas y Técnica