Age-sex disparities and sub-clinical hypothyroidism among patients in Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia

Background: Subclinical hypothyroidism is an elevation in serum thyroid-stimulating hormone above the upper limit of the reference range (0.45\u20134.5 mIU/L) with normal serum TT4 and TT3 concentration. The most important implication of subclinical hypothyroidism is high likelihood of progression of clinical hypothyroidism. Methods: Institution-based cross-sectional study was conducted on medical records of patients referred at endocrine clinic Tikur Anbesa Specialized Hospital, Addis Ababa from 2010 to 2016. This study was conducted from normal ambulatory patients who have come in the hospital outpatient department since they experienced abnormality on their health status. During the study period, patients were complaining about their clinical symptoms. A total number of 9000 patients were included. Patients\u2019 card was retrieved by using standard extracted formats to collect socio-demographic and clinical information and laboratory measurements. Serum TSH, TT4, and TT3 levels were determined by electro-chemiluminescence immunoassay method on ECLIA 2010 fully automatic analyzer at TASH nuclear medicine. SPSS 20 version software was used for analysis, and chi-square test was used to check the association between dependent and independent variables. Results: The overall prevalence of subclinical hypothyroidism evaluated to be 582 (6.47%), 4.6% in females and 1.9% in males. Four hundred and thirty-one (74%) patients had serum TSH levels between 5 and 10 mIU/L, and the average TSH level of subclinical hypothyroid patients whose age was 65 40 differ significantly from that of subclinical hypothyroid patients whose age was < 40. The average TSH level among female patients whose age are 65 40 differed significantly from their counterparts. Subclinical hypothyroidism patients more often reported having dry skin, poor memory, fatigue, cold intolerance, constipation, and hoarseness. Conclusion: The overall prevalence of ScHt was 6.5% where females showed higher level than males. Age 65 40 became independent factor of subclinical hypothyroidism. The higher prevalence of subclinical hypothyroidism in this study could become a predictor for overt hypothyroidism, so screening for subclinical hypothyroidism prevents the later development of complicated overt hypothyroidism

Age-sex disparities and sub-clinical hypothyroidism among patients in Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia

Abstract Background Subclinical hypothyroidism is an elevation in serum thyroid-stimulating hormone above the upper limit of the reference range (0.45–4.5 mIU/L) with normal serum TT4 and TT3 concentration. The most important implication of subclinical hypothyroidism is high likelihood of progression of clinical hypothyroidism. Methods Institution-based cross-sectional study was conducted on medical records of patients referred at endocrine clinic Tikur Anbesa Specialized Hospital, Addis Ababa from 2010 to 2016. This study was conducted from normal ambulatory patients who have come in the hospital outpatient department since they experienced abnormality on their health status. During the study period, patients were complaining about their clinical symptoms. A total number of 9000 patients were included. Patients’ card was retrieved by using standard extracted formats to collect socio-demographic and clinical information and laboratory measurements. Serum TSH, TT4, and TT3 levels were determined by electro-chemiluminescence immunoassay method on ECLIA 2010 fully automatic analyzer at TASH nuclear medicine. SPSS 20 version software was used for analysis, and chi-square test was used to check the association between dependent and independent variables. Results The overall prevalence of subclinical hypothyroidism evaluated to be 582 (6.47%), 4.6% in females and 1.9% in males. Four hundred and thirty-one (74%) patients had serum TSH levels between 5 and 10 mIU/L, and the average TSH level of subclinical hypothyroid patients whose age was ≥ 40 differ significantly from that of subclinical hypothyroid patients whose age was < 40. The average TSH level among female patients whose age are ≥ 40 differed significantly from their counterparts. Subclinical hypothyroidism patients more often reported having dry skin, poor memory, fatigue, cold intolerance, constipation, and hoarseness. Conclusion The overall prevalence of ScHt was 6.5% where females showed higher level than males. Age ≥ 40 became independent factor of subclinical hypothyroidism. The higher prevalence of subclinical hypothyroidism in this study could become a predictor for overt hypothyroidism, so screening for subclinical hypothyroidism prevents the later development of complicated overt hypothyroidism

Predictors of stunting among children 6–59 months of age in Sodo Zuria District, South Ethiopia: a community based cross-sectional study

Abstract Background Despite the decline in the rate of stunting in Ethiopia, the prevalence is still high and needs immense efforts to achieve the target set to reduce the prevalence. It varies between localities due to individual level factors and dominant livelihood practice in the community. Thus, the aim of this study was to determine the prevalence of stunting and identify factors associated with it in Sodo Zuria district in South Ethiopia. Methods A community based cross sectional study was conducted among 342 children aged 6–59 months paired with mothers/caretakers. Households were selected using systematic sampling. Structured questionnaire was used and mothers/caregivers were interviewed face to face. Standardized anthropometric measurements were used to measure length, and weight and height of a child. Data were entered into Epi Info software version 3.5.1 and exported to SPSS version 20 for analysis. Height for age Z score data were analyzed using WHO Anthro software. Multivariate logistic regression analysis was conducted to identify predictor variables. Statistical significance was considered at p  1500, and children who received pre-lacteal feeding (AOR = 3.8; 95% CI: 1.2–12.2) became predictors for stunting. Conclusion Significant proportion of stunting was found where one third of them were severely stunted. Being female, children aged 12–23 months, using family planning, children with diarrheal morbidity, income and pre-lacteal feeding became predictors for stunting. So Gender-based policies should be enacted in child feeding practice, interventions should focus on the utilization of family planning and appropriate child caring and feeding practices. Water, sanitation and hygiene interventions need to be strengthened

Magnitude of wasting and underweight among children 6–59 months of age in Sodo Zuria District, South Ethiopia: a community based cross-sectional study

Abstract Objectives The study aimed to determine the prevalence of wasting and underweight, and identify associated factors in Sodo Zuria district in South Ethiopia. Results The prevalence of wasting and underweight were 11.1% and 14.0%, respectively. Wasting was significantly associated with male gender, diarrheal morbidity 2 weeks prior to the study and early initiation of complementary feeding. Predictors of underweight were diarrheal morbidity 2 weeks prior to the study and paternal illiteracy. The prevalence of wasting and underweight among under-five children is common in the study area. Diarrheal morbidity was associated with both wasting and underweight. Interventions targeting prevention of diarrheal morbidity through hygienic practices and creating awareness on infant feeding practices need to be implemented in the study area