Impact of depression on quality of life in people living with human T cell lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-07-25T18:25:14Z No. of bitstreams: 1 Galvão-CAstro Ana V Impact of depression....pdf: 203393 bytes, checksum: 8400c241a5ceb2c680c3a458c1d11c73 (MD5)Made available in DSpace on 2014-07-25T18:25:14Z (GMT). No. of bitstreams: 1 Galvão-CAstro Ana V Impact of depression....pdf: 203393 bytes, checksum: 8400c241a5ceb2c680c3a458c1d11c73 (MD5) Previous issue date: 2011Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilPurpose A previous study found the prevalence of depression in HTLV-1-infected patients to be approximately 30%, but few studies have attempted to correlate depression with quality of life (QOL) in these patients. The present study investigates the association between depression and QOL in people living with HTLV-1. Methods A clinical-epidemiological questionnaire, the Mini International Neuropsychiatric Interview and the WHOQOLBref were applied to 88 HTLV-1-infected patients (32 with TSP/HAM) at the HTLV Center of the Bahiana School of Medicine and Public Health, Salvador, Brazil. Results The prevalence of depression among people living with HTLV-1 was 34.1%. Depression was significantly associated with a poor QOL in the physical, psychological, social relationship and environment domains, when controlling for other variables, such as gender, age, time of knowledge of serological diagnosis and presence of tropical spastic paraparesis/HTLV-1associated myelopathy (TSP/ HAM). Moreover, patients with TSP/HAM experienced a reduction in their QOL in the physical, psychological and environment domains. Conclusion Our results showed that depression negatively affects the quality of life of people living with HTLV-1, regardless of the presence of TSP/HAM. Since it is possible to improve a patient’s QOL by treating depression, psychological evaluations are strongly recommended as a measure to integrate the treatment protocols of HTLV-1 intervention programs

Perfil sociodemográfico, epidemiológico e comportamental de mulheres infectadas pelo HTLV-1 em Salvador-Bahia, uma área endêmica para o HTLV

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-07-30T18:17:16Z No. of bitstreams: 1 Moxoto I Perfil socfiodemográfico....pdf: 102366 bytes, checksum: 1dd9ed08c0a4733d4d8b648616355175 (MD5)Made available in DSpace on 2014-07-30T18:17:16Z (GMT). No. of bitstreams: 1 Moxoto I Perfil socfiodemográfico....pdf: 102366 bytes, checksum: 1dd9ed08c0a4733d4d8b648616355175 (MD5) Previous issue date: 2007Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilO objetivo foi descrever as características sociodemográficas, epidemiológicas e comportamentais de mulheres infectadas (64) e não infectadas (66) pelo HTLV-1 em Salvador, Bahia. O diagnóstico sorológico foi obtido por ELISA, WB e Imunofluorescência. Dados epidemiológicos e sociodemográficos foram coletados utilizando questionário padronizado. O Qui-quadrado ou teste de Fisher foi usado para dados categóricos e ANOVA ou Kruskall Wallis (3 grupos) e teste T ou Mann Whitney (2 grupos) para os dados contínuos. As variáveis associadas foram ajustadas por regressão logística. Mais da metade (57,8%) das mulheres soropositivas eram assintomáticas. As sintomáticas (com PET/MAH) tinham menor escolaridade. A comparação entre mulheres soropositivas e soronegativas mostrou que a hemotransfusão, a prática de sexo anal, coitarca antes dos 18 anos e ter mais de 3 parceiros sexuais na vida foram fatores de risco para infecção pelo HTLV-1. A prevenção da transmissão sexual e vertical (aleitamento materno) deve ser reforçada e triagem no pré-natal mandatória.The objective was to describe the sociodemographic, epidemiological and behavioral characteristics of women infected with HTLV-1 (64) and uninfected women (66) in Salvador, Bahia. The serological diagnosis was obtained via ELISA, Western Blot and Immunofluorescence. Epidemiological and sociodemographic data were collected using a standardized questionnaire. The chi-squared or Fisher test was used for categorical data and ANOVA or Kruskal-Wallis (3 groups) and the T-test or Mann-Whitney (2 groups) were used for continuous data. Associated variables were adjusted using logistic regression. More than half (57.8%) of the seropositive women were asymptomatic. The symptomatic women (with HAM/TSP) had fewer years of education. Comparison between seronegative and seropositive women showed that blood transfusion, anal sex practices, first sexual intercourse before the age of 18 years and three or more sexual partners over women’s lifetime were risk factors for HTLV-1 infection. The prevention of both sexual transmission and vertical transmission (breastfeeding) should be reinforced. Prenatal screening is of paramount importance

Ocular lesions in sickle cell disease patients from Bahia, Brazil / Lesões oculares em pacientes com doença falciforme da Bahia, Brasil

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2012-12-26T17:06:30Z No. of bitstreams: 1 Cury, Dayse et al. Ocular lesions....pdf: 474784 bytes, checksum: b4f51c9b830e4e065d0a86a9e6332e55 (MD5)Made available in DSpace on 2012-12-26T17:06:30Z (GMT). No. of bitstreams: 1 Cury, Dayse et al. Ocular lesions....pdf: 474784 bytes, checksum: b4f51c9b830e4e065d0a86a9e6332e55 (MD5) Previous issue date: 2010Instituto Brasileiro de Oftalmologia e Prevenção a Cegueira. Salvador, BA, Brasil / Fundação para o Desenvolvimento das Ciências da Bahia. Escola de Medicina e Saúde Pública da Bahia. Salvador, BA, BrasilFundação para o Desenvolvimento das Ciências da Bahia. Escola de Medicina e Saúde Pública da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, BrasilFundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, BrasilInstituto Brasileiro de Oftalmologia e Prevenção a Cegueira. Salvador, BA, Brasil / Fundação para o Desenvolvimento das Ciências da Bahia. Escola de Medicina e Saúde Pública da Bahia. Salvador, BA, BrasilFundação para o Desenvolvimento das Ciências da Bahia. Escola de Medicina e Saúde Pública da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises. Salvador, BA, BrasilO presente estudo teve como objetivo descrever as alterações oculares em pacientes portadores de doença falciforme, na Bahia, um estado do Nordeste, que tem a maior prevalência da doença no Brasil. MÉTODOS: Nós conduzimos um estudo de corte transversal em um grupo de 146 (292 olhos) pacientes com Doença Falciforme (90 HBSS e 56 HBSC). Para exame oftalmológico foi realizada oftalmoscopia binocular indireta complementada pela retinografia fluorescente para detecção de lesões retinianas decorrentes da Doença Falciforme. RESULTADOS: As lesões mais frequentemente encontradas foram o aumento da tortuosidade vascular e "black sumburst" Retinopatia proliferativa foi encontrada em 22 (12,2 por cento) olhos de pacientes HBSS e 25 (22,3 por cento) olhos de pacientes HBSC (OR=2.06; CI95 por cento: 1.5-4.06, p=0. 022); essa frequência foi maior entre os pacientes HBSS com idade entre 20 - 39 anos, enquanto que nos pacientes HBSC foi maior nos acima de 40 anos (35.7 por cento e 42.8 por cento), decaindo abruptamente após essa idade. CONCLUSÃO: Retinopatia proliferativa foi descrita por volta dos dez anos de idade em ambos os grupos. A prevalência da retinopatia falciforme proliferativa pode resultar em cegueira e o conhecimento das alterações oculares mais prevalentes e idade de risco destas em pacientes com Doença Falciforme será importante para estabelecer um protocolo de acompanhamento oftalmológico, para prevenir um dano visual clinicamente grave, aumentando a qualidade de vida destes pacientes.The present study aims to describe ocular alterations in sickle cell disease patients in Bahia, a Northeast state, with the highest prevalence of the disease in Brazil. METHODS: We carried out a cross-sectional study in a group of 146 (292 eyes) sickle cell disease patients (90 HBSS and 56 HBSC). Ophthalmologic examination including indirect binocular ophthalmoscopy was performed. Examination was completed by fluorescein angiography to detect retinal lesions. RESULTS: The most frequent ocular lesions identified were "vascular tortuosity" and "black sunburst". Proliferative retinopathy was found in 22 (12.2 percent) eyes of HBSS patients and 25 (22.3 percent) eyes of HBSC patients (OR=2.06; CI95 percent: 1.5-4.06, p=0.022); Its frequency was higher among HBSS patients aged 20-39 years, while in HBSC patients, it peaked after 40 years (35.7 percent and 42.8 percent) and dropped sharply afterwards. CONCLUSION: Proliferative retinopathy was described as early as 10 years of age in both patients groups. Proliferative sickle retinopathy can result in blindness and the knowledge of the most prevalent ocular alterations and age risk will be important to establish a protocol of ophthalmologic follow-up, in order to prevent a severe visual loss and increase patient's life quality

No evidence of osteoporosis in young HTLV-1-infected carriers

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-09-25T18:40:05Z No. of bitstreams: 1 Santos A C S No evidence....pdf: 107798 bytes, checksum: a07b04c3aa76f9c2ca440e22d5dfaef7 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2014-09-25T18:40:17Z (GMT) No. of bitstreams: 1 Santos A C S No evidence....pdf: 107798 bytes, checksum: a07b04c3aa76f9c2ca440e22d5dfaef7 (MD5)Made available in DSpace on 2014-09-25T19:35:17Z (GMT). No. of bitstreams: 1 Santos A C S No evidence....pdf: 107798 bytes, checksum: a07b04c3aa76f9c2ca440e22d5dfaef7 (MD5) Previous issue date: 2014Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, BrasilBahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, BrasilBahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, BrasilState University of Santa Cruz. UESC. Itabuna, Bahia, BrasilBahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilBahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, BrasilBahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilOsteoporosis has been reported among Human T-cell Lymphotropic Virus type 1 (HTLV-1) infected aged patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) diagnosis. However, the association between osteoporosis and HTLV-1 infection remains unclear. This study aimed to evaluate the presence of bone disorders in young HTLV-1 asymptomatic individuals. A cross sectional study was carried out at the HTLV Reference Center in Salvador, Brazil. Forty-seven HTLV-1 infected asymptomatic and 108 healthy subjects aged between 20 to 45 years were included. Biochemical markers of bone metabolism were measured and bone mineral density (BMD) was determined at the femoral neck and at the lumbar spine (L1 -L4). Significant low BMD (Z-score <-1 ) was found in HTLV-1 infected individuals (1.177 ± 0.103) compared to control subjects (1.225 ± 0.146). In logistics regression analysis HTLV-1 infected subjects were more likely to have low BMD (OR = 3.48; 95%CI 1.29- 9.43) adjusted for low education and body mass index (BMI). Osteoporosis (Z-score <-2) was not found among HTLV-1-infected group. In conclusion, our results found a low BMD in patients infected with HTLV-1 compared to uninfected controls. However, osteoporosis was not observed. Further studies should be conducted to evaluate the relationship between HTLV-1-infection and low BMD

Segmental absence of intestinal musculature - presentation in a 10-year-old boy with an extensive involved segment

Freitas, Luiz Antonio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2017-07-12T17:06:41Z No. of bitstreams: 1 Athanazio DA Segmental Absence of IntestinalMusculature.pdf: 3557207 bytes, checksum: ee89eb17976189d246217dc021b2e4d4 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2017-07-12T17:18:13Z (GMT) No. of bitstreams: 1 Athanazio DA Segmental Absence of IntestinalMusculature.pdf: 3557207 bytes, checksum: ee89eb17976189d246217dc021b2e4d4 (MD5)Made available in DSpace on 2017-07-12T17:18:13Z (GMT). No. of bitstreams: 1 Athanazio DA Segmental Absence of IntestinalMusculature.pdf: 3557207 bytes, checksum: ee89eb17976189d246217dc021b2e4d4 (MD5) Previous issue date: 2015Federal University of Bahia. Salvador, BA, Brasil.Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil.Federal University of Bahia. Faculty of Medicine. Salvador, BA, Brasil.Federal University of Bahia. Faculty of Medicine. Salvador, BA, Brasil.Federal University of Bahia. Faculty of Medicine. Salvador, BA, Brasil.Federal University of Bahia. Salvador, BA, Brasil.Federal University of Bahia. Salvador, BA, Brasil.Segmental absence of the intestinal musculature is a rare cause of acute abdomen most likely associated with intestinal perforation and sepsis in neonates and adults. We present a case of a 10-year-old boy who developed acute abdomen and was treated with right hemicolectomy and partial resection of the ileum. The ileum showed a 20-cm-long stenotic segment showing prominent thinning of the intestinal wall. This case occurred in an older child, which appears to be rare when comparing the literature. The bowel defect was also the largest described to date, indicating the potential effect of an atonic segment leading to obstructive disease