IceCube-Plus: An Ultra-High Energy Neutrino Telescope

While the first kilometer-scale neutrino telescope, IceCube, is under construction, alternative plans exist to build even larger detectors that will, however, b e limited by a much higher neutrino energy threshold of 10 PeV or higher rather than 10 to 100 GeV. These future projects detect radio and acoustic pulses as w ell as air showers initiated by ultra-high energy neutrinos. As an alternative, we here propose an expansion of IceCube, using the same strings, placed on a gri d with a spacing of order 500 m. Unlike other proposals, the expanded detector uses methods that are understood and calibrated on atmospheric neutrinos. Atmosp heric neutrinos represent the only background at the energies under consideratio n and is totally negligible. Also, the cost of such a detector is understood. We conclude that supplementing the 81 IceCube strings with a modest number of addi tional strings spaced at large distances can almost double the effective volume of the detector. Doubling the number of strings on a 800 m grid can deliver a d etector that this a factor of 5 larger for horizontal muons at modest cost.Comment: Version to be published in JCA

The purpose of mess in action research: building rigour though a messy turn

Mess and rigour might appear to be strange bedfellows. This paper argues that the purpose of mess is to facilitate a turn towards new constructions of knowing that lead to transformation in practice (an action turn). Engaging in action research - research that can disturb both individual and communally held notions of knowledge for practice - will be messy. Investigations into the 'messy area', the interface between the known and the nearly known, between knowledge in use and tacit knowledge as yet to be useful, reveal the 'messy area' as a vital element for seeing, disrupting, analysing, learning, knowing and changing. It is the place where long-held views shaped by professional knowledge, practical judgement, experience and intuition are seen through other lenses. It is here that reframing takes place and new knowing, which has both theoretical and practical significance, arises: a 'messy turn' takes place

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes

An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone. It is a paradigm for the direct regulation of signaling effectors by the Gβγ G-protein subunit. Many questions have been addressed in heterologous expression systems with less focus on the behaviour in native myocytes partly because of the technical difficulties in undertaking comparable studies in native cells. In this study, we characterise a potassium current in the atrial-derived cell line HL-1. Using an electrophysiological approach, we compare the characteristics of the potassium current with those in native atrial cells and in a HEK cell line expressing the cloned Kir3.1/3.4 channel. The potassium current recorded in HL-1 is inwardly rectifying and activated by the muscarinic agonist carbachol. Carbachol-activated currents were inhibited by pertussis toxin and tertiapin-Q. The basal current was time-dependently increased when GTP was substituted in the patch-clamp pipette by the non-hydrolysable analogue GTPγS. We compared the kinetics of current modulation in HL-1 with those of freshly isolated atrial mouse cardiomyocytes. The current activation and deactivation kinetics in HL-1 cells are comparable to those measured in atrial cardiomyocytes. Using immunofluorescence, we found GIRK4 at the membrane in HL-1 cells. Real-time RT-PCR confirms the presence of mRNA for the main G-protein subunits, as well as for M2 muscarinic and A1 adenosine receptors. The data suggest HL-1 cells are a good model to study IKAch

Pre-service teachers’ engagement in a cross-curricular television news project: impact on professional identity

This paper focuses on the impact of pre-service teachers’ engagement in the annual BBC News School Report project on their emerging professional identity and on the evidence they provide as part of the process of becoming qualified. The research reported on is drawn from three years of enquiry. Respondents included pre-service teachers themselves, their tutors as representatives of teacher education providers and their mentors as representatives of schools in which they were placed. The methodological approach was interpretative and phenomenological with qualitative and quantitative data being analysed for emergent themes. Two years of evaluations were followed by a third year in which a set of case studies were developed. The research showed that professional identity is enhanced through being in a leading role in respect of curriculum and working with other staff. Through engagement in such projects, this paper moots that preservice teachers develop richer evidence of emerging professionalism as defined by standards of initial teacher training. Moreover, self-perception of role was modified to one in which they saw themselves, and were seen, as equals to qualified staff rather than subservient to or dependent on them. A new more equal power relationship developed as they took on responsibility for the project. Preservice teachers’ move to become full members of the professional community for which they are training was accelerated

Frequency spectra of cosmic ray air shower radio emission measured with LOPES

Aims. We wish to study the spectral dependence of the radio emission from cosmic-ray air showers around .Methods. We observe short radio pulses in a broad frequency band with the dipole-interferometer LOPES (LOFAR Prototype Station), which is triggered by a particle detector array named Karlsruhe Shower Core and Array Detector (KASCADE). LOFAR is the Low Frequency Array. For this analysis, 23 strong air shower events are selected using parameters from KASCADE. The radio data are digitally beam-formed before the spectra are determined by sub-band filtering and fast Fourier transformation.Results. The resulting electric field spectra fall off to higher frequencies. An average electric field spectrum is fitted with an exponential and , or alternatively, with a power law and a spectral index of . The spectral slope obtained is not consistent within uncertainties and it is slightly steeper than the slope obtained from Monte Carlo simulations based on air showers simulated with CORSIKA (Cosmic Ray Simulations for KASCADE). For the analyzed sample of LOPES events, we do not find any significant dependence of the spectral slope on the electric field amplitude, the azimuth angle, the zenith angle, the curvature radius, nor on the average distance of the antennae from the shower core position. But one of the strongest events was measured during thunderstorm activity in the vicinity of LOPES and shows the longest pulse length measured of and a spectral slope of .Conclusions. We show with two different methods that frequency spectra from air shower radio emission can be reconstructed on event-by-event basis, with only two dozen dipole antennae simultaneously over a broad range of frequencies. According to the obtained spectral slopes, the maximum power is emitted below 40 MHz. Furthermore, the decrease in power to higher frequencies indicates a loss in coherence determined by the shower disc thickness. We conclude that a broader bandwidth, larger collecting area, and longer baselines, as will be provided by LOFAR, are necessary to further investigate the relation of the coherence, pulse length, and spectral slope of cosmic ray air showers

Corroborating indicates nurses’ ethical values in a geriatric ward

The aim of the study was to identify nurses’ ethical values, which become apparent through their behaviour in the interactions with older patients in caring encounters at a geriatric clinic