Determination of Strange Sea Quark Distributions from Fixed-target and Collider Data

We present an improved determination of the strange sea distribution in the nucleon with constraints coming from the recent charm production data in neutrino-nucleon deep-inelastic scattering by the NOMAD and CHORUS experiments and from charged current inclusive deep-inelastic scattering at HERA. We demonstrate that the results are consistent with the data from the ATLAS and the CMS experiments on the associated production of $W^\pm$-bosons with $c$-quarks. We also discuss issues related to the recent strange sea determination by the ATLAS experiment using LHC collider data.Comment: 23 pages, 14 figure

Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling

Posttranslational modifications (PTM) have been shown to be essential for protein function and signaling. Here we report the identification of a novel modification, protein transfer of histamine, and provide evidence for its function in G protein signaling. Histamine, known as neurotransmitter and mediator of the inflammatory response, was found incorporated into mastocytoma proteins. Histaminylation was dependent on transglutaminase II. Mass spectrometry confirmed histamine modification of the small and heterotrimeric G proteins Cdc42, Galphao1 and Galphaq. The modification was specific for glutamine residues in the catalytic core, and triggered their constitutive activation. TGM2-mediated histaminylation is thus a novel PTM that functions in G protein signaling. Protein alphamonoaminylations, thus including histaminylation, serotonylation, dopaminylation and norepinephrinylation, hence emerge as a novel class of regulatory PTMs

The Small-x Behaviour of the Singlet Polarized Structure Function g_2 in the Double Logarithmic Approximation

The small-x behavior of the singlet contributions to the polarized structure function g_2(x,Q^2) is calculated in the double-logarithmic approximation of perturbative QCD. The dominant contribution is due to the gluons which, in contrast to the unpolarized case, mix with the fermions also in the small-x domain. We find a power-like growth in 1/x in the odd-signature parts of the amplitude with the same power as in the singlet function g_1(x,Q^2) at x<< 1.Comment: 20 pages, latex, 3 ps figure

Modified Wandzura-Wilczek Relation with the Nachtmann Variable

If one retains M^2/Q^2 terms in the kinematics, the Nachtmann variable \xi seems to be more appropriate to describe deep inelastic lepton-nucleon scattering. Up to the first power of M^2/Q^2, a modified Wandzura-Wilczek relation with respect to \xi was derived. Kinematical correction factors are given as functions of \xi and Q^2. A comparison of the modified g_2^WW(\xi) and original g_2^WW(x) with the most recent g_2 data is shown.Comment: 10 pages, 3 figures, revised version with minor correction

Aging (Albany NY)

The combination of functional genomics with next generation sequencing facilitates new experimental strategies for addressing complex biological phenomena. Here, we report the identification of a gain-of-function allele of peroxiredoxin (thioredoxin peroxidase, Tsa1p) via whole-genome re-sequencing of a dominantSaccharomyces cerevisiae mutant obtained by chemical mutagenesis. Yeast strain K6001, a screening system for lifespan phenotypes, was treated with ethyl methanesulfonate (EMS). We isolated an oxidative stress-resistant mutant (B7) which transmitted this phenotype in a background-independent, monogenic and dominant way. By massive parallel pyrosequencing, we generated an 38.8 fold whole-genome coverage of the strains, which differed in 12,482 positions from the reference (S288c) genome. Via a subtraction strategy, we could narrow this number to 13 total and 4 missense nucleotide variations that were specific for the mutant. Via expression in wild type backgrounds, we show that one of these mutations, exchanging a residue in the peroxiredoxin Tsa1p, was responsible for the mutant phenotype causing background-independent dominant oxidative stress-resistance. These effects were not provoked by altered Tsa1p levels, nor could they be simulated by deletion, haploinsufficiency or over-expression of the wild-type allele. Furthermore, via both a mother-enrichment technique and a micromanipulation assay, we found a robust premature aging phenotype of this oxidant-resistant strain. Thus, TSA1-B7 encodes for a novel dominant form of peroxiredoxin, and establishes a new connection between oxidative stress and aging. In addition, this study shows that the re-sequencing of entire genomes is becoming a promising alternative for the identification of functional alleles in approaches of classic molecular genetics

Higher Twist, ξw\xi_w Scaling, and Effective LOPDFsLO PDFs for Lepton Scattering in the Few GeV Region

We use a new scaling variable $\xi_w$, and add low $Q^2$ modifications to GRV98 leading order parton distribution functions such that they can be used to model electron, muon and neutrino inelastic scattering cross sections (and also photoproduction) at both very low and high energies.Comment: 6 pages, 3 figures. To be published in J. Phys. G (Conf. Proceedings) based on two talks by Arie Bodek at the NuFact$'02$ conference, Imperial College, London, England, July 200

Constraints from Precision Electroweak Data on Leptoquarks and Bileptons

Explicit expressions are derived for the oblique parameters $S$ and $T$ in certain extensions of the standard model. In particular, we consider leptoquarks and bileptons, and find phenomenological constraints on their allowed masses. Leptoquarks suggested by the neutral and charged current anomalies at HERA can give improved agreement with both $S$ and $T$. If bileptons are the only new states, the singly-charged one must be heavier than the directly-established lower limit. Finally, we study SU(15) grand unification and show that there are regions of parameter space where the theory is compatible with experimental data.Comment: 25 pages LaTeX including 7 figures. With improved comparison to experimental data and other update

The Large Hadron-Electron Collider at the HL-LHC

The Large Hadron–Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron–proton and proton–proton operations. This report represents an update to the LHeC’s conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton–nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron–hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies