24 research outputs found
Regulation of nickel-induced T-cell responsiveness by CD4+CD25+ cells in contact allergic patients and healthy individuals
Regulation of nickel-induced T-cell responsiveness by CD4+CD25+ cells in contact allergic patients and healthy individuals
Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons
Toll-like receptor agonists and invariant natural killer T-cells enhance antibody-dependent cell-mediated cytotoxicity (ADCC)
Differential indirect activation of human invariant natural killer T-cells by Toll-like receptor agonists
AIM: Invariant natural killer (iNK) T cells are activated by bacterial glycosphingolipids presented by CD1d on dendritic cells (DCs). Here, it was investigated whether Toll-like receptor (TLR) ligands derived from various microorganisms can either directly or indirectly (through DC activation) activate iNKT cells. MATERIALS & METHODS: TLR expression by iNKT cells was examined and the ability of various TLR ligands to activate iNKT cells was evaluated. RESULTS: Although human iNKT cells express all TLRs, apart from TLR8, they did not respond directly to TLR ligands. However, iNKT cells became strongly activated when total peripheral blood mononuclear cells were stimulated with TLR2/6, 7/8 and 9 ligands, but not or to a lesser extent with TLR3, 4 and 5 ligands. TLR-stimulated monocyte-derived DCs promoted iNKT cell phenotypic activation and, in turn, these activated iNKT cells further enhanced DC maturation. CONCLUSION: TLR agonists may act as strong adjuvants for immunotherapy by promoting combined and reciprocal activation of iNKT cells and DC
Serum intestinal-fatty acid binding protein as a biomarker for refractory celiac disease
Specific Celiac Disease Antibodies in Children on a Gluten-Free Diet
Epidemiology in Pediatrics and Child Healt