HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

© 2014 Landes Bioscience. PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner. Furthermore, a proportion of hypoxic PTK6 subsequently re-localized to the cell membrane. We observed that the rapid stabilization of PTK6 is associated with a decrease in PTK6 ubiquitylation and we have identified c-Cbl as a putative PTK6 E3 ligase in normoxia. The consequences of hypoxia-induced PTK6 stabilization and subcellular re-localization to the plasma membrane include increased cell motility and invasion, suggesting PTK6 targeting as a therapeutic approach to reduce hypoxia-regulated metastatic potential. This could have particular significance for breast cancer patients with triple negative disease

Measurements of the Casimir-Lifshitz force in fluids: the effect of electrostatic forces and Debye screening

In this work, we present detailed measurements of the Casimir-Lifshitz force between two gold surfaces (a sphere and a plate) immersed in ethanol and study the effect of residual electrostatic forces, which are dominated by static fields within the apparatus and can be reduced with proper shielding. Electrostatic forces are further reduced by Debye screening through the addition of salt ions to the liquid. Additionally, the salt leads to a reduction of the Casimir-Lifshitz force by screening the zero-frequency contribution to the force; however, the effect is small between gold surfaces at the measured separations and within experimental error. An improved calibration procedure is described and compared to previous methods. Finally, the experimental results are compared to Lifshitz's theory and found to be consistent for the materials used in the experiment.Comment: 11 figures. PRA in pres

Hadronic Light-by-Light Contribution to Muon g-2 in Chiral Perturbation Theory

We compute the hadronic light-by-light scattering contributions to the muon anomalous magnetic moment, \amulbl, in chiral perturbation theory that are enhanced by large logarithms and a factor of $N_C$. They depend on a low-energy constant entering pseudoscalar meson decay into a charged lepton pair. The uncertainty introduced by this constant is $\pm 60\times 10^{-11}$, which is comparable in magnitude to the present uncertainty entering the leading-order vacuum polarization contributions to the anomalous moment. It may be reduced to some extent through an improved measurement of the $\pi^0\to e^+ e^-$ branching ratio. However, the dependence of \amulbl on non-logarithmically enhanced effects cannot be constrained except through the measurement of the anomalous moment itself. The extraction of information on new physics would require a future experimental value for the anomalous moment differing significantly from the 2001 result reported by the E821 collaboration.Comment: 7 pages, 2 figure

Water in the Green Economy: Capacity Development Aspects

This book discusses needs related to capacity development for water resources management, including water supply and sanitation, in the context of the green economy. It showcases theoretical and practical approaches with proven success. Most contributions come from members and partners within the interagency mechanism, UN-Water. The 11 case studies in this book range from innovative design and delivery of capacity development programs related to water in the green economy, market mechanisms, and quality control procedures supporting capacity development success towards the practical implementation of programs to enhance individual and institutional capacity

Pion pole contribution to hadronic light-by-light scattering and muon anomalous magnetic moment

We derive an analytic result for the pion pole contribution to the light-by-light scattering correction to the anomalous magnetic moment of the muon, $a_\mu = (g_\mu-2)/2$. Using the vector meson dominance model (VMD) for the pion transition form factor, we obtain $a_\mu^{{\rm LBL},\pi^0} = +56 \times 10^{-11}$.Comment: 4 pages, revte

Anomalous Neutrino Interaction, Muon g-2, and Atomic Parity Nonconservation

We propose a simple unified description of two recent precision measurements which suggest new physics beyond the Standard Model of particle interactions, i.e. the deviation of $\sin^2 \theta_W$ in deep inelastic neutrino-nucleon scattering and that of the anomalous magnetic moment of the muon. Our proposal is also consistent with a third precision measurement, i.e. that of parity nonconservation in atomic Cesium, which agrees with the Standard Model.Comment: 9 pages, including 1 figure, latest muon g-2 information adde

Contributions of semi-hadronic states Pγ;Sγ,π+π−γP\gamma;S\gamma, \pi^+\pi^-\gamma to amm of muon, in frames of Nambu-Jona-Lasinio model

We calculate the contribution of semi-hadronic states with pseudoscalar $P=\pi^0, \eta$ and scalar ($\sigma$(550))meson accompanied with real photon as an intermediate state of a heavy photon to the anomalous magnetic moment of muon. We consider the intermediate states with $\pi_0$ and $\sigma$ as a hadrons in frames of Nambu-Jona-Lasinio model. The contribution of $\pi_0\gamma$ state is in agreement with results obtained in previous theoretical considerations as well as with experimental data $a_\mu^{\pi_0\gamma}\approx 4.5 \times 10^{-10}$, besides we estimate $a_{\mu}^{\eta\gamma}=0.7 \times 10^{-10}, a_{\mu}^{\sigma\gamma} \sim 1.5 \times 10^{-11}, a_{\mu}^{\pi^+\pi^-\gamma} \sim 3.2 \times 10^{-10}.$ We discass as well the LbL mechanism with $a_{\mu}^{lbl}=10.5 \cdot 10^{-10}.$Comment: 6 pages, 2 figure

Een oude vraag opnieuw onderzocht: effecten van korte gevangenisstraffen ten opzichte van niet-vrijheidsbenemende straffen op recidive op basis van een instrumentele variabele benadering

Hervorming Sociale RegelgevingCriminal Justice: Legitimacy, accountability, and effectivit