Использование технологий m-learning в высшем образовании: проблемы и перспективы

The article draws attention to the fact that although the use of information technologies in education is widespread and actively discussed, the practice of using mobile digital devices in education is much less common and studied. It is noted that the widespread use of mobile digital devices has led to the active use of mobile applications by students for educational tasks. However, the institutional response to the new trend by educational institutions remains very limited and largely experimental. The article provides an overview and analysis of the modern practice of integration of mobile technologies in the educational process. It is revealed that mobile technologies can be successfully applied not only as an alternative way of access to educational resources, but also for reorganization and increase of flexibility of educational process, expansion of opportunities of interaction of students, teachers and administration, expansion of experience directly during classroom work.В статье рассматривается проблема недостаточного распространения и изучения практики применения в образовании мобильных цифровых устройств, хотя использование информационных технологий в образовании является повсеместным и активно обсуждаемым. Широкое распространение мобильных цифровых устройств привело к активному использованию студентами мобильных приложений для решения учебных задач. Однако институциональная реакция на новый тренд со стороны учебных заведений остается крайне ограниченной и носит преимущественно экспериментальный характер. Приведены обзор и анализ современной практики интеграции мобильных технологий в образовательный процесс. Выявлено, что мобильные технологии могут успешно применяться не только в качестве альтернативного способа доступа к образовательным ресурсам, но также для реорганизации и повышения гибкости учебного процесса, расширения возможностей взаимодействия студентов, преподавателей и администрации, углубления опыта непосредственно в ходе аудиторной работы

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key upstream transcriptome regulator in AH and induces the use of HNF4α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4α-dependent gene expression. We conclude that targeting TGFβ1 and epigenetic drivers that modulate HNF4α-dependent gene expression could be beneficial to improve hepatocellular function in patients with AH

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key upstream transcriptome regulator in AH and induces the use of HNF4α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4α-dependent gene expression. We conclude that targeting TGFβ1 and epigenetic drivers that modulate HNF4α-dependent gene expression could be beneficial to improve hepatocellular function in patients with AH

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key upstream transcriptome regulator in AH and induces the use of HNF4α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4α-dependent gene expression. We conclude that targeting TGFβ1 and epigenetic drivers that modulate HNF4α-dependent gene expression could be beneficial to improve hepatocellular function in patients with AH