8 research outputs found
Universal scaling laws of chaotic escape in dissipative multistable systems subjected to autoresonant excitations
A theory concerning the emergence and control of chaotic escape from a
potential well by means of autoresonant excitations is presented in the context
of generic, dissipative, and multistable systems. Universal scaling laws
relating both the onset and lifetime of transient chaos with the parameters of
autoresonant excitations are derived theoretically using vibrational mechanics,
Melnikov analysis, and energy-based autoresonance theory. Numerical experiments
show that these scaling laws are robust against both the presence of noise and
re-shaping.Comment: 4 pages, 5 figure
Artificial Brownian motors: Controlling transport on the nanoscale
In systems possessing spatial or dynamical symmetry breaking, Brownian motion
combined with symmetric external input signals, deterministic or random, alike,
can assist directed motion of particles at the submicron scales. In such cases,
one speaks of "Brownian motors". In this review the constructive role of
Brownian motion is exemplified for various one-dimensional setups, mostly
inspired by the cell molecular machinery: working principles and
characteristics of stylized devices are discussed to show how fluctuations,
either thermal or extrinsic, can be used to control diffusive particle
transport. Recent experimental demonstrations of this concept are reviewed with
particular attention to transport in artificial nanopores and optical traps,
where single particle currents have been first measured. Much emphasis is given
to two- and three-dimensional devices containing many interacting particles of
one or more species; for this class of artificial motors, noise rectification
results also from the interplay of particle Brownian motion and geometric
constraints. Recently, selective control and optimization of the transport of
interacting colloidal particles and magnetic vortices have been successfully
achieved, thus leading to the new generation of microfluidic and
superconducting devices presented hereby. Another area with promising potential
for realization of artificial Brownian motors are microfluidic or granular
set-ups.....Comment: 57 pages, 39 figures; submitted to Reviews Modern Physics, revised
versio
Multimodality treatment of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) in the elderly
Introduction: This subgroup analysis of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) from the PERSARC collaborative group aimed to achieve a more personalized multimodality treatment approach for primary eUPS in elderly patients.Material and methods: A multicenter retrospective study including primary high-grade eUPS surgically treated with curative intent between 2000 and 2016. Overall survival (OS), local recurrence (LR) and distant metastasis (DM) curves were calculated by Kaplan Meier analysis. Cox proportional hazard models were used to determine the effect of radiotherapy.Results: From a total of 2511 patients with extremity soft tissue sarcoma (eSTS) of the PERSARC study collaborative; 703 patients with eUPS were included in this study. In elderly patients with eUPS 5-year OS, LR and DM were 35.4 (95%CI 29.3-42.8), 17.7 (95%CI 12.7-22.6) and 24.6 (95%CI 19.1-30.1). eUPS was significantly less treated with radiotherapy compared with other eSTS, especially in elderly patients. Patients with R1-R2 margins treated with radiotherapy had about half the risk of developing LR compared with patients treated without radiotherapy (HR = 0.454, p = 0.033).Conclusion: Elderly patients with eUPS were less often treated with radiotherapy and showed higher LR. Nowadays, given an increasing life expectancy in elderly patients, multimodality treatment should be considered. (C) 2021 The Authors. Published by Elsevier Ltd
Multimodality treatment of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) in the elderly
Introduction: This subgroup analysis of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) from the PERSARC collaborative group aimed to achieve a more personalized multimodality treatment approach for primary eUPS in elderly patients.Material and methods: A multicenter retrospective study including primary high-grade eUPS surgically treated with curative intent between 2000 and 2016. Overall survival (OS), local recurrence (LR) and distant metastasis (DM) curves were calculated by Kaplan Meier analysis. Cox proportional hazard models were used to determine the effect of radiotherapy.Results: From a total of 2511 patients with extremity soft tissue sarcoma (eSTS) of the PERSARC study collaborative; 703 patients with eUPS were included in this study. In elderly patients with eUPS 5-year OS, LR and DM were 35.4 (95%CI 29.3-42.8), 17.7 (95%CI 12.7-22.6) and 24.6 (95%CI 19.1-30.1). eUPS was significantly less treated with radiotherapy compared with other eSTS, especially in elderly patients. Patients with R1-R2 margins treated with radiotherapy had about half the risk of developing LR compared with patients treated without radiotherapy (HR = 0.454, p = 0.033).Conclusion: Elderly patients with eUPS were less often treated with radiotherapy and showed higher LR. Nowadays, given an increasing life expectancy in elderly patients, multimodality treatment should be considered. (C) 2021 The Authors. Published by Elsevier Ltd.Orthopaedics, Trauma Surgery and Rehabilitatio