Problematització històrica dels conceptes "gènere" i "sexe" en la ciència occidental

Premi UAB de l'Observatori per a la Igualtat als millors Treballs de Fi de Grau amb perspectiva de gènere. 4a Edició, curs 2018-2019En el present treball d'investigació es realitza un anàlisi històric, social i científic dels conceptes de gènere i sexe. Emprant eines heurístiques proporcionades per l'anàlisi feminista i històric, es parteix des de la primera concepció del sexe (prèvia a la dicotomia sexual i a la separació conceptual del gènere) fins a l'enteniment dicotòmic que es té actualment, passant alhora per diferents moviments ideològics i filosòfics que han portat a la redefinició científica dels conceptes i a problematitzacions en diversos moments històrics. Alhora, amb aquest treball es busca revisar el punt de vista científic actual sobre els conceptes de sexe y gènere (i aquells que són producte dels primers) en un intent d'enriquir la biologia, permetent la desconstrucció de la perspectiva hegemònica i estimulant-la a cercar noves bases i aplicacions horitzontals i incloents del coneixement

HOPE (SOLTI-1903) breast cancer study: real-world, patient-centric, clinical practice study to assess the impact of genomic data on next treatment decision-choice in patients with locally advanced or metastatic breast cancer

Background Metastatic breast cancer (mBC) causes nearly all BC-related deaths. Next-generation sequencing (NGS) technologies allow for the application of personalized medicine using targeted therapies that could improve patients' outcomes. However, NGS is not routinely used in the clinical practice and its cost induces access-inequity among patients. We hypothesized that promoting active patient participation in the management of their disease offering access to NGS testing and to the subsequent medical interpretation and recommendations provided by a multidisciplinary molecular advisory board (MAB) could contribute to progressively overcome this challenge. We designed HOPE (SOLTI-1903) breast cancer trial, a study where patients voluntarily lead their inclusion through a digital tool (DT). The main objectives of HOPE study are to empower mBC patients, gather real-world data on the use of molecular information in the management of mBC and to generate evidence to assess the clinical utility for healthcare systems.Trial design After self-registration through the DT, the study team validates eligibility criteria and assists patients with mBC in the subsequent steps. Patients get access to the information sheet and sign the informed consent form through an advanced digital signature. Afterwards, they provide the most recent (preferably) metastatic archival tumor sample for DNA-sequencing and a blood sample obtained at the time of disease progression for ctDNA analysis. Paired results are reviewed by the MAB, considering patient's medical history. The MAB provides a further interpretation of molecular results and potential treatment recommendations, including ongoing clinical trials and further (germline) genetic testing. Participants self-document their treatment and disease evolution for the next 2 years. Patients are encouraged to involve their physicians in the study. HOPE also includes a patient empowerment program with educational workshops and videos about mBC and precision medicine in oncology. The primary endpoint of the study was to describe the feasibility of a patient-centric precision oncology program in mBC patients when a comprehensive genomic profile is available to decide on a subsequent line of treatment