The North Atlantic subpolar circulation in an eddy-resolving global ocean model

The subpolar North Atlantic represents a key region for global climate, but most numerical models still have well-described limitations in correctly simulating the local circulation patterns. Here, we present the analysis of a 30-year run with a global eddy-resolving (1/12°) version of the NEMO ocean model. Compared to the 1° and 1/4° equivalent versions, this simulation more realistically represents the shape of the Subpolar Gyre, the position of the North Atlantic Current, and the Gulf Stream separation. Other key improvements are found in the representation of boundary currents, multi-year variability of temperature and depth of winter mixing in the Labrador Sea, and the transport of overflows at the Greenland–Scotland Ridge. However, the salinity, stratification and mean depth of winter mixing in the Labrador Sea, and the density and depth of overflow water south of the sill, still present challenges to the model. This simulation also provides further insight into the spatio-temporal development of the warming event observed in the Subpolar Gyre in the mid 1990s, which appears to coincide with a phase of increased eddy activity in the southernmost part of the gyre. This may have provided a gateway through which heat would have propagated into the gyre's interior

Efficacy of Cognitive and Metacognitive Interventions on Executive Functioning Post Traumatic Brain Injury to Enhance Occupational Performance

Cognitive rehabilitation (CR) is proposed as an effective intervention for individuals post Traumatic Brain Injury (TBI), by addressing cognitive function through remediating skills and practicing new compensatory skills. While there is considerable research, including systematic reviews that explore cognitive interventions post TBI, more research is needed in which occupational performance is the primary outcome of cognitive intervention. This current systematic review aims to synthesize the current body of evidence available on how using CR techniques to address executive functioning impact occupational performance in individuals who sustained a mild or moderate TBI

PKA-Dependent Phosphorylation of Serum Response Factor Inhibits Smooth Muscle-Specific Gene Expression

Our goal was to identify phosphorylation sites that regulate serum response factor (SRF) activity to gain a better understanding of the signaling mechanisms that regulate SRF’s involvement in smooth muscle cell (SMC)-specific and early response gene expression

Intensified Aleutian Low induces weak Pacific Decadal Variability

The Aleutian Low drives decadal variability in North Pacific sea surface temperatures (SST), but its role in basin-wide Pacific SST variability is less clear owing to the difficulty of disentangling coupled atmosphere-ocean processes. We apply local atmospheric nudging to isolate the effects of an intense winter Aleutian Low using an intermediate complexity climate model. An intensified Aleutian Low produces a basin-wide SST response with a similar pattern to internally-generated Pacific Decadal Oscillation (PDO). The amplitude of the SST response in the North Pacific is comparable to PDO, but in the tropics and southern subtropics the anomalies induced by the intense Aleutian Low are a factor of 3 weaker. The tropical Pacific warming peaks in boreal spring, though anomalies persist year-round. A heat budget analysis shows the northern subtropical Pacific SST response is predominantly driven by anomalous surface heat fluxes in boreal winter, while in the equatorial Pacific the response is mainly due to meridional heat advection in boreal spring. The propagation of anomalies from the extratropics to the tropics can be explained by the seasonal footprinting mechanism, involving the wind-evaporation-SST feedback. The results show that low frequency variability and trends in the Aleutian Low could contribute to basin-wide anomalous Pacific SST, but the magnitude of the effect cannot explain the full amplitude of the PDO. This finding suggests that external forcing of the Aleutian Low is unlikely to explain observed shifts in the phase of PDO in the late 20th and early-21st centuries

Formin Homology Domain-Containing Protein 1 Regulates Smooth Muscle Cell Phenotype

Our goal was to test whether formin homology protein 1 (FHOD1) plays a significant role in the regulation of SMC differentiation, and if so, whether Rho-kinase (ROCK)-dependent phosphorylation in the diaphanous auto-inhibitory domain is an important signaling mechanism that controls FHOD1 activity in SMC

Sustained intensification of the Aleutian Low induces weak tropical Pacific sea surface warming

It has been proposed that externally forced trends in the Aleutian Low can induce a basin-wide Pacific sea surface temperature (SST) response that projects onto the pattern of the Pacific Decadal Oscillation (PDO). To investigate this hypothesis, we apply local atmospheric nudging in an intermediate-complexity climate model to isolate the effects of an intensified winter Aleutian Low sustained over several decades. An intensification of the Aleutian Low produces a basin-wide SST response with a similar pattern to the model's internally generated PDO. The amplitude of the SST response in the North Pacific is comparable to the PDO, but in the tropics and southern subtropics the anomalies induced by the imposed Aleutian Low anomaly are a factor of 3 weaker than for the internally generated PDO. The tropical Pacific warming peaks in boreal spring, though anomalies persist year-round. A heat budget analysis shows the northern subtropical Pacific SST response is predominantly driven by anomalous surface turbulent heat fluxes in boreal winter, while in the equatorial Pacific the response is mainly due to meridional heat advection in boreal spring. The propagation of anomalies from the extratropics to the tropics can be explained by the seasonal footprinting mechanism, involving the wind–evaporation–SST feedback. The results show that low-frequency variability and trends in the Aleutian Low could contribute to basin-wide anomalous Pacific SST, but the magnitude of the effect in the tropical Pacific, even for the extreme Aleutian Low forcing applied here, is small. Therefore, external forcing of the Aleutian Low is unlikely to account for observed decadal SST trends in the tropical Pacific in the late 20th and early 21st centuries

Inclusion at Scale: Deploying a Community-Driven Moderation Intervention on Twitch

Harassment, especially of marginalized individuals, on networked gaming and social media platforms has been identified as a significant issue, yet few HCI practitioners have attempted to create interventions tackling toxicity online. Aligning ourselves with the growing cohort of design activists, we present a case study of the GLHF pledge, an interactive public awareness campaign promoting positivity in video game live streaming. We discuss the design and deployment of a community-driven moderation intervention for GLHF, intended to empower the inclusive communities emerging on Twitch. After offering a preliminary report on the effects we have observed based on the more than 370,000 gamers who have participated to date, the paper concludes with a reflection on the challenges and opportunities of using design activism to positively intervene in large-scale media platforms

NEAT: An efficient network enrichment analysis test

Background: Network enrichment analysis is a powerful method, which allows to integrate gene enrichment analysis with the information on relationships between genes that is provided by gene networks. Existing tests for network enrichment analysis deal only with undirected networks, they can be computationally slow and are based on normality assumptions. Results: We propose NEAT, a test for network enrichment analysis. The test is based on the hypergeometric distribution, which naturally arises as the null distribution in this context. NEAT can be applied not only to undirected, but to directed and partially directed networks as well. Our simulations indicate that NEAT is considerably faster than alternative resampling-based methods, and that its capacity to detect enrichments is at least as good as the one of alternative tests. We discuss applications of NEAT to network analyses in yeast by testing for enrichment of the Environmental Stress Response target gene set with GO Slim and KEGG functional gene sets, and also by inspecting associations between functional sets themselves. Conclusions: NEAT is a flexible and efficient test for network enrichment analysis that aims to overcome some limitations of existing resampling-based tests. The method is implemented in the R package neat, which can be freely downloaded from CRAN ( https://cran.r-project.org/package=neat )