The NASA-IGES geometry data visualizer

NIGESview, an interactive software tool for reading, viewing, and translating geometry data available in the Initial Graphics Exchange Specification (IGES) format, is described. NIGESview is designed to read a variety of IGES entities, translate some of the entities, graphically view the data, and output a file in a specific IGES format. The software provides a modern graphical user interface and is designed in a modular fashion so developers can utilize all or part of the code in their grid generation software for computational fluid dynamics

The NASA-IGES geometry data exchange standard

Described here are the data exchange efforts and plans supported by the NASA Steering Committee for Surface Modeling and Grid Generation. Current methods for geometry data exchange between computer aided design (CAD) systems and NASA computational fluid dynamics (CFD) analysis systems are tedious and induce errors. A Geometry Data Exchange Standard is proposed, utilizing a subset of an existing national standard titled Initial Graphic Exchange Standard (IGES). Future plans for data exchange standardization include all aspects of CFD data. Software systems to utilize this NASA-IGES Geometry Data Exchange Specification are under development

NASA geometry data exchange specification for computational fluid dynamics (NASA IGES)

This document specifies a subset of an existing product data exchange specification that is widely used in industry and government. The existing document is called the Initial Graphics Exchange Specification. This document, a subset of IGES, is intended for engineers analyzing product performance using tools such as computational fluid dynamics (CFD) software. This document specifies how to define mathematically and exchange the geometric model of an object. The geometry is represented utilizing nonuniform rational B-splines (NURBS) curves and surfaces. Only surface models are represented; no solid model representation is included. This specification does not include most of the other types of product information available in IGES (e.g., no material properties or surface finish properties) and does not provide all the specific file format details of IGES. The data exchange protocol specified in this document is fully conforming to the American National Standard (ANSI) IGES 5.2

Multicenter Clinical Evaluation of the Xpert GBS LB Assay for Detection of Group B Streptococcus in Prenatal Screening Specimens

Neonatal infection with Streptococcus agalactiae (group B Streptococcus [GBS]) is a leading cause of sepsis and meningitis in newborns. Recent guidelines have recommended universal screening of all pregnant women to identify those colonized with GBS and administration of peripartum prophylaxis to those identified as carriers to reduce the risk of early-onset GBS disease in neonates. Enriched culture methods are the current standard for prenatal GBS screening; however, the implementation of more sensitive molecular diagnostic tests may be able to further reduce the risk of early-onset GBS infection. We report a clinical evaluation of the Xpert GBS LB assay, a molecular diagnostic test for the identification of GBS from broth-enriched vaginal/rectal specimens obtained during routine prenatal screening. A total of 826 specimens were collected from women undergoing prenatal screening (35 to 37 weeks' gestation) and tested at one of three clinical centers. Each swab specimen was tested directly prior to enrichment using the Xpert GBS assay. Following 18 to 24 h of broth enrichment, each specimen was tested using the Xpert GBS LB assay and the FDA-cleared Smart GBS assay as a molecular diagnostic comparator. Results obtained using all three molecular tests were compared to those for broth-enriched culture as the gold standard. The sensitivity and specificity of the Xpert GBS LB assay were 99.0% and 92.4%, respectively, compared to those for the gold standard culture. The Smart GBS molecular test demonstrated sensitivity and specificity of 96.8% and 95.5%, respectively. The sensitivities of the two broth-enriched molecular methods were superior to those for direct testing of specimens using the Xpert GBS assay, which demonstrated sensitivity and specificity of 85.7% and 96.2%, respectively

Vertebrate Natural History Notes from Arkansas, 2018

Because meaningful observations of natural history are not always part of larger studies, important pieces of information often are unreported. Small details, however, can fill gaps in understanding and lead to interesting questions about ecological relationships or environmental change. We have compiled recent important observations of distribution, deformities, and foods of various vertebrates, observations of winter activity of a woodchuck (Marmota monax) and winter torpor of a hoary bat (Lasiurus cinereus), and also report a very unusual case of bilateral gynandromorphism in a Cardinal (Cardinalis cardinalis). These unique observations continue to add immensely to the growth of knowledge of the biology of vertebrates in Arkansas

Multicenter Evaluation of the Portrait Staph ID/R Blood Culture Panel for Rapid Identification of Staphylococci and Detection of the mecA Gene

Bloodstream infections are a leading cause of morbidity and mortality in the United States and are associated with increased health care costs. We evaluated the Portrait Staph ID/R blood culture panel (BCP) multiplex PCR assay (Great Basin Scientific, Salt Lake City, UT) for the rapid and simultaneous identification (ID) of Staphylococcus aureus, Staphylococcus lugdunensis, and Staphylococcus species to the genus level and the detection of the mecA gene directly from a positive blood culture bottle. A total of 765 Bactec bottles demonstrating Gram-positive cocci in singles or clusters were tested during the prospective trial at 3 clinical sites. The Portrait Staph ID/R BCP results were compared with results from conventional biochemical and cefoxitin disk methods performed at an independent laboratory. Discordant ID and mecA results were resolved by rpoB gene sequencing and mecA gene sequencing, respectively. A total of 658 Staphylococcus species isolates (S. aureus, 211 isolates; S. lugdunensis, 3 isolates; and Staphylococcus spp., 444 isolates) were recovered from monomicrobial and 33 polymicrobial blood cultures. After discrepant analysis, the overall ratios of Portrait Staph ID/R BCP positive percent agreement and negative percent agreement were 99.4%/99.9% for Staphylococcus ID and 99.7%/99.2% for mecA detection

Estimating Household and Community Transmission of Ocular Chlamydia trachomatis

Trachoma is a major cause of blindness worldwide and results from ocular infection with the bacterium Chlamydia trachomatis. Mass distribution of antibiotics in communities is part of the strategy to eliminate blindness due to trachoma. Targeted treatment of infected households could be more efficient, but the success of such a strategy will depend on the extent of transmission of infection between members of the same household and between members of the community. In this work, we estimated the magnitude of household and community transmission in four populations, two from The Gambia and two from Tanzania. We found that, in general, transmission of the bacteria within households is very efficient. In three of the four populations, persistent infection within households was predicted by the high level of household transmission (a phenomenon observed in longitudinal studies of trachoma). In all of the studied populations, individuals who live in households with more individuals contribute more to the number of new infections in the community than those who live with fewer individuals. Further studies are required to identify and examine household-targeted approaches to treatment

Investigating the Interplay between Glucose Regulation, Neural Activity, and Motivation: A Novel Approach Utilizing Vibration Stimulation

This research explores the intricate relationship between glucose regulation, neural activity, and motivation in key brain regions, including the hypothalamus, basal ganglia, ventral tegmental area (VTA), and nucleus accumbens (NA). We aim to unravel the potential relationship of these factors on dopamine (DA) release and the broader implications for mental health, glucose regulation, well-being, and overall health. Our innovative approach involves using a chair that causes heterodyned whole-body vibration designed to stimulate DA release from the VTA and NA, areas associated with motivation and rewards

High-resolution infrared studies of the ν10, ν11, ν14, and ν18 levels of [1.1.1]propellane

This paper is a continuation of earlier work in which the high resolution infrared spectrum of [1.1.1]propellane was measured and its k and l structure resolved for the first time. Here we present results from an analysis of more than 16,000 transitions involving three fundamental bands v₁₀ (E' - A'₁), v₁₁ (E' - A'₁), v₁₄ (A"₂ - A'₁) and two difference bands (v₁₀–v₁₈) (E' - E") and (v₁₁ - v₁₈) (E' - E"). Additional information about v₁₈ was also obtained from the difference band (v₁₅ + v₁₈) - v₁₈ (E' - E") and the binary combination band (v₁₅ + v₁₈) (E' - A'₁). Through the use of the ground state constants reported in an earlier paper [1], rovibrational constants have been determined for all the vibrational states involved in these bands. The rovibrational parameters for the v₁₈ (E") state were obtained from combination–differences and showed no need to include interactions with other states. The v₁₀ (E') state analysis was also straight-forward, with only a weak Coriolis interaction with the levels of the v₁₄ (A"₂) state. The latter levels are much more affected by a strong Coriolis interaction with the levels of the nearby v₁₁ (E') state and also by a small but significant interaction with another state, presumably the v₁₆ (E") state, that is not directly observed. Gaussian calculations (B3LYP/cc-pVTZ) computed at the anharmonic level aided the analyses by providing initial values for many of the parameters. These theoretical results generally compare favorably with the final parameter values deduced from the spectral analyses. Finally, evidence was obtained for several level crossings between the rotational levels of the v₁₁ and v₁₄ states and, using a weak coupling term corresponding to a Δk = ±5, Δl = ∓1 matrix element, it was possible to find transitions from the ground state that, combined with transitions to the same upper state, give a value of C₀ = 0.1936515(4) cm⁻¹. This result, combined with the value of B₀ = 0.28755833(14) cm⁻¹ reported earlier [1], yields a value of 1.586277(3) Å for the length of the novel axial CC bond in propellane